Gene Review:
Rhob - ras homolog gene family, member B
Mus musculus
Synonyms:
AA017882, Arh6, Arhb, Rho-related GTP-binding protein RhoB
- Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Jiang, K., Sun, J., Cheng, J., Djeu, J.Y., Wei, S., Sebti, S. Mol. Cell. Biol. (2004)
- RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Adini, I., Rabinovitz, I., Sun, J.F., Prendergast, G.C., Benjamin, L.E. Genes Dev. (2003)
- Small GTP-binding protein RhoB is expressed in glial Müller cells in the vertebrate retina. Santos-Bredariol, A.S., Belmonte, M.A., Kihara, A.H., Santos, M.F., Hamassaki, D.E. J. Comp. Neurol. (2006)
- RhoB expression is induced after the transient upregulation of RhoA and Cdc42 during neuronal differentiation and influenced by culture substratum and microtubule integrity. Laplante, I., Paquin, J., Béliveau, R. Brain Res. Dev. Brain Res. (2001)
- Genetic response to DNA damage: proapoptotic targets of RhoB include modules for p53 response and susceptibility to Alzheimer's disease. Kamasani, U., Prendergast, G.C. Cancer Biol. Ther. (2005)
- Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. Schuebel, K.E., Movilla, N., Rosa, J.L., Bustelo, X.R. EMBO J. (1998)
- Normal thyroid structure and function in rhophilin 2-deficient mice. Behrends, J., Clément, S., Pajak, B., Pohl, V., Maenhaut, C., Dumont, J.E., Schurmans, S. Mol. Cell. Biol. (2005)
- RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Liu, A.X., Rane, N., Liu, J.P., Prendergast, G.C. Mol. Cell. Biol. (2001)
- Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication. Milia, J., Teyssier, F., Dalenc, F., Ader, I., Delmas, C., Pradines, A., Lajoie-Mazenc, I., Baron, R., Bonnet, J., Cohen-Jonathan, E., Favre, G., Toulas, C. Cell Death Differ. (2005)
- Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition. Kamasani, U., Huang, M., Duhadaway, J.B., Prochownik, E.V., Donover, P.S., Prendergast, G.C. Cancer Res. (2004)
- Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. Fleming, I.N., Elliott, C.M., Exton, J.H. J. Biol. Chem. (1996)
- The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments. Fritz, G., Kaina, B., Aktories, K. J. Biol. Chem. (1995)
- Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. Stamatakis, K., Cernuda-Morollón, E., Hernández-Perera, O., Pérez-Sala, D. J. Biol. Chem. (2002)
- RhoB mRNA is stabilized by HuR after UV light. Westmark, C.J., Bartleson, V.B., Malter, J.S. Oncogene (2005)
- RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Sandilands, E., Cans, C., Fincham, V.J., Brunton, V.G., Mellor, H., Prendergast, G.C., Norman, J.C., Superti-Furga, G., Frame, M.C. Dev. Cell (2004)
- Selective expression of the small GTPase RhoB in the early developing mouse lens. Maddala, R., Peng, Y.W., Rao, P.V. Dev. Dyn. (2001)
- GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice. Trapp, T., Oláh, L., Hölker, I., Besselmann, M., Tiesler, C., Maeda, K., Hossmann, K.A. Mol. Cell. Neurosci. (2001)