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Gene Review

Kcnn2  -  potassium channel, calcium activated...

Rattus norvegicus

Synonyms: KCa2.2, SK2, SKCa 2, SKCa2, Small conductance calcium-activated potassium channel protein 2
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Psychiatry related information on Kcnn2

  • Furthermore, while no behavioral disturbances during spatial acquisition in the Morris water maze were observed with overexpression of either channel, animals overexpressing SK2, but not Kv1.1, exhibited a memory deficit post-training [1].

High impact information on Kcnn2

  • In contrast to SK2, the SK3 subunit was detected neither in the developing nor in the adult retina [2].
  • These results show cell-specific expression of the SK2 subunit in the retina and suggest that this channel underlies the apamin-sensitive AHP currents described in retinal ganglion cells [2].
  • Evoked IPSCs had biphasic waveforms at -60 mV, were blocked reversibly by alpha-bungarotoxin and strychnine and are most likely mediated by the alpha9/alpha10 acetylcholine receptor, with subsequent activation of calcium-dependent potassium (SK2) channels [3].
  • In the absence of insult, overexpression of Kv1.1, but not SK2, reduced baseline excitability in dentate gyrus granule cells [1].
  • We found that SK2 or Kv1.1 protected not only against kainate or glutamate excitotoxicity but also increased survival after sodium cyanide or staurosporine [1].

Biological context of Kcnn2


Anatomical context of Kcnn2

  • In cell lines, methyl-noscapine blocked SK1, SK2 and SK3 currents with mean IC(50)s of 5.9, 5.6 and 3.9 microM, respectively [5].
  • We investigated whether the expression in the vestibular and facial nuclei of the voltage-dependent Na alpha I and Na alpha III channels and of the Ca(2+)-activated K(+)-channel subunits, small-conductance (SK) 1, SK2 and SK3, is affected by unilateral inner-ear lesion including both labyrinthectomy and transsection of the facial nerve [6].
  • Following unilateral inner ear lesion in rats, the medial vestibular nuclei were probed with Na alpha I, Na alpha III, SK1, SK2 and SK3 oligonucleotide probes: autoradiography indicated no difference between the two sides, at any of the times studied [6].
  • Whole-cell recording showed a sharp segregation of apamin-sensitive SK current within the hippocampal formation, in agreement with the SK2 distribution, suggesting that SK2 homotetramers underlie the apamin-sensitive medium afterhyperpolarizations in rat hippocampus [7].
  • Immunohistochemistry revealed a restricted distribution of SK1 and SK2 protein with highest densities in subregions of the hippocampus and neocortex [7].

Associations of Kcnn2 with chemical compounds

  • We used patch clamp to study the actions of the neuroprotective drug riluzole on recombinant SK2 channels expressed in HEK293 cells and native SK channels underlying the afterhyperpolarization current (I(AHP)) in cultured hippocampal neurons [8].
  • Amitriptyline, carbamazepine, chlorpromazine, cyproheptadine, imipramine, tacrine and trifluperazine blocked SK2 channel currents with micromolar affinity [9].
  • Butanol, ethanol, ketamine, lidocaine, and methohexital blocked recombinant SK2 channel currents, measured in the whole-cell patch clamp recording mode [10].

Other interactions of Kcnn2


Analytical, diagnostic and therapeutic context of Kcnn2


  1. Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults. Lee, A.L., Dumas, T.C., Tarapore, P.E., Webster, B.R., Ho, D.Y., Kaufer, D., Sapolsky, R.M. J. Neurochem. (2003) [Pubmed]
  2. Developmental expression of the small-conductance Ca(2+)-activated potassium channel SK2 in the rat retina. Klöcker, N., Oliver, D., Ruppersberg, J.P., Knaus, H.G., Fakler, B. Mol. Cell. Neurosci. (2001) [Pubmed]
  3. Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat. Goutman, J.D., Fuchs, P.A., Glowatzki, E. J. Physiol. (Lond.) (2005) [Pubmed]
  4. A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. Kramár, E.A., Lin, B., Lin, C.Y., Arai, A.C., Gall, C.M., Lynch, G. J. Neurosci. (2004) [Pubmed]
  5. Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. Scuvée-Moreau, J., Boland, A., Graulich, A., Van Overmeire, L., D'hoedt, D., Graulich-Lorge, F., Thomas, E., Abras, A., Stocker, M., Liégeois, J.F., Seutin, V. Br. J. Pharmacol. (2004) [Pubmed]
  6. Modulation of the voltage-gated sodium- and calcium-dependent potassium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve transsection: an in situ hybridization study. Patkó, T., Vassias, I., Vidal, P.P., De Waele, C. Neuroscience (2003) [Pubmed]
  7. Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain. Sailer, C.A., Hu, H., Kaufmann, W.A., Trieb, M., Schwarzer, C., Storm, J.F., Knaus, H.G. J. Neurosci. (2002) [Pubmed]
  8. Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole. Cao, Y.J., Dreixler, J.C., Couey, J.J., Houamed, K.M. Eur. J. Pharmacol. (2002) [Pubmed]
  9. Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Dreixler, J.C., Bian, J., Cao, Y., Roberts, M.T., Roizen, J.D., Houamed, K.M. Eur. J. Pharmacol. (2000) [Pubmed]
  10. Patch-clamp analysis of anesthetic interactions with recombinant SK2 subtype neuronal calcium-activated potassium channels. Dreixler, J.C., Jenkins, A., Cao, Y.J., Roizen, J.D., Houamed, K.M. Anesth. Analg. (2000) [Pubmed]
  11. Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones. Pedarzani, P., Kulik, A., Muller, M., Ballanyi, K., Stocker, M. J. Physiol. (Lond.) (2000) [Pubmed]
  12. Medium afterhyperpolarization and firing pattern modulation in interneurons of stratum radiatum in the CA3 hippocampal region. Savić, N., Pedarzani, P., Sciancalepore, M. J. Neurophysiol. (2001) [Pubmed]
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