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Gene Review

CEP55  -  centrosomal protein 55kDa

Homo sapiens

Synonyms: C10orf3, CT111, Centrosomal protein of 55 kDa, Cep55, FLJ10540, ...
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Disease relevance of CEP55


High impact information on CEP55


Biological context of CEP55


Anatomical context of CEP55

  • In microtubule regrowth assays, overexpression of CEP55 did not enhance or inhibit microtubule nucleation [3].
  • Here we describe the molecular characterization of a novel human gene, CEP55, located in 10q23.33 that is expressed in multiple tissues and various cancer cell lines [3].

Associations of CEP55 with chemical compounds


Regulatory relationships of CEP55


Other interactions of CEP55


  1. Elevated expression of C10orf3 (chromosome 10 open reading frame 3) is involved in the growth of human colon tumor. Sakai, M., Shimokawa, T., Kobayashi, T., Matsushima, S., Yamada, Y., Nakamura, Y., Furukawa, Y. Oncogene (2006) [Pubmed]
  2. Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. Zhao, W.M., Seki, A., Fang, G. Mol. Biol. Cell (2006) [Pubmed]
  3. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. Martinez-Garay, I., Rustom, A., Gerdes, H.H., Kutsche, K. Genomics (2006) [Pubmed]
  4. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Fabbro, M., Zhou, B.B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M.E., Gabrielli, B.G., Robinson, P.J., Nigg, E.A., Ono, Y., Khanna, K.K. Dev. Cell (2005) [Pubmed]
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