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Gene Review

CAMK2N1  -  calcium/calmodulin-dependent protein...

Homo sapiens

Synonyms: CaMKII inhibitory protein alpha, CaMKIIN-alpha, CaMKIINalpha, Calcium/calmodulin-dependent protein kinase II inhibitor 1
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High impact information on CAMK2N1


Biological context of CAMK2N1


Anatomical context of CAMK2N1


Associations of CAMK2N1 with chemical compounds


Physical interactions of CAMK2N1


Enzymatic interactions of CAMK2N1

  • Conversely, the mutation T38A produces an analog of ICAP-1alpha that cannot be phosphorylated and that stimulates cell spreading on fibronectin to a similar extent when CaMKII is inhibited [4].

Other interactions of CAMK2N1


Analytical, diagnostic and therapeutic context of CAMK2N1

  • Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, residues predicted by the model to be in close proximity to (792)NPKY(795), and Leu(82) and Tyr(144), residues expected to form a hydrophobic pocket near Val(787), are required for the Icap1 alpha-beta(1) integrin interaction [5].
  • Quantitative real-time PCR revealed that the hippocampal expression of CaMKIINalpha mRNA was up-regulated 30 and 60 min after conditioning [6].


  1. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. Chang, D.D., Wong, C., Smith, H., Liu, J. J. Cell Biol. (1997) [Pubmed]
  2. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Calderwood, D.A., Fujioka, Y., de Pereda, J.M., García-Alvarez, B., Nakamoto, T., Margolis, B., McGlade, C.J., Liddington, R.C., Ginsberg, M.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. Bouvard, D., Vignoud, L., Dupé-Manet, S., Abed, N., Fournier, H.N., Vincent-Monegat, C., Retta, S.F., Fassler, R., Block, M.R. J. Biol. Chem. (2003) [Pubmed]
  4. Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha. Bouvard, D., Block, M.R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. Chang, D.D., Hoang, B.Q., Liu, J., Springer, T.A. J. Biol. Chem. (2002) [Pubmed]
  6. An endogenous inhibitor of calcium/calmodulin-dependent kinase II is up-regulated during consolidation of fear memory. Lepicard, E.M., Mizuno, K., Antunes-Martins, A., von Hertzen, L.S., Giese, K.P. Eur. J. Neurosci. (2006) [Pubmed]
  7. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. Fournier, H.N., Dupé-Manet, S., Bouvard, D., Lacombe, M.L., Marie, C., Block, M.R., Albiges-Rizo, C. J. Biol. Chem. (2002) [Pubmed]
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