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Gene Review

NAGK  -  N-acetylglucosamine kinase

Homo sapiens

Synonyms: GNK, GlcNAc kinase, HSA242910, N-acetyl-D-glucosamine kinase
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Disease relevance of NAGK


High impact information on NAGK

  • Structural comparison of StHK with human N-acetylglucosamine kinase and other hexokinases provides an explanation for the ability of StHK to phosphorylate both glucose and N-acetylglucosamine [4].
  • N-Acetyl-L-glutamate kinase (NAGK), the structural paradigm of the enzymes of the amino acid kinase family, catalyzes the phosphorylation of the gamma-COO(-) group of N-acetyl-L-glutamate (NAG) by ATP [5].
  • The active site is too narrow to accommodate the substrates without compressing the reacting groups, and this compressive strain appears a crucial component of the catalytic mechanism of NAGK, and possibly of other enzymes of the amino acid kinase family such as carbamate kinase [5].
  • The integrity of Ser49, a residue conserved in PII proteins from organisms that perform oxygenic photosynthesis, appears to be essential for NAGK binding [2].
  • Murine N-acetylglucosamine kinase contains six cysteine residues, all of which were mutated to serine residues [6].

Biological context of NAGK

  • Previous biochemical studies have indicated that allosteric regulation of the first and, especially, the second steps in Orn synthesis (NAGS; N-acetylglutamate kinase (NAGK), EC by the Arg end-product are the major sites of metabolic control of the pathway in organisms using the cyclic pathway [7].
  • In Daucus carota, N-acetylglutamate-5-phosphotransferase (NAGK; E.C. specific activity was shown to correlate with the progression of somatic embryogenesis and was highest in the latter stages, where growth was most rapid [8].
  • Gene expression profiling for pathway enzymes further suggests that NAGS, NAGK, NAOGAcT and NAOD are coordinately regulated in response to changes in Arg demand during plant growth and development [7].

Anatomical context of NAGK


Associations of NAGK with chemical compounds


  1. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. Lowes, W., Walker, M., Alberti, K.G., Agius, L. Biochim. Biophys. Acta (1998) [Pubmed]
  2. Interactions between the nitrogen signal transduction protein PII and N-acetyl glutamate kinase in organisms that perform oxygenic photosynthesis. Burillo, S., Luque, I., Fuentes, I., Contreras, A. J. Bacteriol. (2004) [Pubmed]
  3. Interaction of N-acetylglutamate kinase with a PII-like protein in rice. Sugiyama, K., Hayakawa, T., Kudo, T., Ito, T., Yamaya, T. Plant Cell Physiol. (2004) [Pubmed]
  4. Crystal Structures of an ATP-dependent Hexokinase with Broad Substrate Specificity from the Hyperthermophilic Archaeon Sulfolobus tokodaii. Nishimasu, H., Fushinobu, S., Shoun, H., Wakagi, T. J. Biol. Chem. (2007) [Pubmed]
  5. The course of phosphorus in the reaction of N-acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF(4)(-) transition state mimic. Gil-Ortiz, F., Ramón-Maiques, S., Fita, I., Rubio, V. J. Mol. Biol. (2003) [Pubmed]
  6. Structure and function of N-acetylglucosamine kinase. Identification of two active site cysteines. Berger, M., Chen, H., Reutter, W., Hinderlich, S. Eur. J. Biochem. (2002) [Pubmed]
  7. Genes, enzymes and regulation of arginine biosynthesis in plants. Slocum, R.D. Plant Physiol. Biochem. (2005) [Pubmed]
  8. N-acetyl glutamate kinase from Daucus carota suspension cultures: embryogenic expression profile, purification and characterization. Lohmeier-Vogel, E.M., Loukanina, N., Ferrar, T.S., Moorhead, G.B., Thorpe, T.A. Plant Physiol. Biochem. (2005) [Pubmed]
  9. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. Weidanz, J.A., Campbell, P., Moore, D., DeLucas, L.J., Rodén, L., Thompson, J.N., Vezza, A.C. Br. J. Haematol. (1996) [Pubmed]
  10. Radioisotopic 51Cr-leukocyte adherence inhibition (LAI) assay. I. Demonstration of anti-tumor immunity in patients with breast carcinoma. Tsang, P.H., Tangnavarad, K., Lesnick, G., Perloff, M., Holland, J.F., Bekesi, J.G. J. Immunol. Methods (1980) [Pubmed]
  11. Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro. Zeitler, R., Giannis, A., Danneschewski, S., Henk, E., Henk, T., Bauer, C., Reutter, W., Sandhoff, K. Eur. J. Biochem. (1992) [Pubmed]
  12. Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans. Yamada-Okabe, T., Sakamori, Y., Mio, T., Yamada-Okabe, H. Eur. J. Biochem. (2001) [Pubmed]
  13. Biosynthesis of N-acetylneuraminic acid in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Hinderlich, S., Berger, M., Keppler, O.T., Pawlita, M., Reutter, W. Biol. Chem. (2001) [Pubmed]
  14. Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. Wendland, J., Hellwig, D., Walther, A., Sickinger, S., Shadkchan, Y., Martin, R., Bauer, J., Osherov, N., Tretiakov, A., Saluz, H.P. J. Basic Microbiol. (2006) [Pubmed]
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