The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SEPT3  -  septin 3

Homo sapiens

Synonyms: Neuronal-specific septin-3, SEP3, bK250D10.3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SEPT3

 

Psychiatry related information on SEPT3

 

High impact information on SEPT3

  • Remarkably, SEP3-like gene expression in the Impatiens perianth is absent from the green sepals but present in the petaloid sepal and in the petals [6].
  • E-class genes, of which SEP3 is a representative, have been identified as redundant mediators that confer transcriptional activation potential on protein complexes that specify organ identity [6].
  • Septin 3 is a novel member of the septin subfamily of GTPase domain proteins [3].
  • Alternative splicing of the septin 3 gene transcript produces two isoforms, A and B, in the human brain, though their regional expression and physiological function remain to be determined [3].
  • Genotype analyses indicated that polymorphic septin 3 alleles were distributed in two peaks of frequency in both control and disease groups [4].
 

Biological context of SEPT3

  • Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation [1].
  • Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals [7].
  • We discuss several candidate mechanisms for heterotopic petaloidy involving modified gene expression and protein interaction of SEP3-like and class B genes [6].
  • OBJECTIVE: To assess success rates in ability to penetrate (Sexual Encounter Profile question 2 [SEP2]) and maintain erections to completion of intercourse (SEP3) from time of dosing to start of sexual activity in a retrospective analysis of two pivotal trials [8].
  • Sexual intercourse was successfully completed (SEP3) in 69% and 84% of patients taking on-demand tadalafil and daily tadalafil, respectively, compared with 30% at baseline (P < 0.001) [9].
 

Anatomical context of SEPT3

  • Antibodies raised against a peptide containing phospho-Ser-91 detected phospho-Sept3 only in the cytosol of nerve terminals, whereas Sept3 was located in a peripheral membrane extract [7].
  • These proteins are involved in vesicle trafficking, neurite outgrowth, and neurofibrillary tangle formation; however, the expression and functional role of septin 3 in normal neuronal tissues and as an etiological agent in neurological disorders is currently unclear [4].
 

Associations of SEPT3 with chemical compounds

  • There are two motifs for potential PKG-I phosphorylation in Sept3, Thr-55 and Ser-91, but phosphoamino acid analysis revealed that the primary site is a serine [7].
  • Vardenafil improved successful SEP3 rates ranging from 58% to 74% compared to 22-34% for placebo [10].
  • The time between sildenafil ingestion and intercourse attempt (0-0.5 to >10 hours) had no significant effect on responses to SEP2, but decreased responses to SEP3 from a maximum of 92.8% at 1.5-2 hours to 81.6% at more than 10 hours (P = 0.003) [11].
 

Other interactions of SEPT3

  • The location of phosphorylation in Sept2 differs from the sites predicted for cGMP-dependent protein kinase (PKG) phosphorylation in Septin 3, raising the possibility that different septins may undergo distinct phosphorylation events that could control their functions in important cellular processes such as neurotransmission or cytokinesis [12].
  • Septin 3 mRNAs for isoforms A and B, but not C, were detected in the frontal cortex of fetus and adult human samples, as measured by reverse transcription-coupled polymerase chain reaction [4].

References

  1. Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation. Methner, A., Leypoldt, F., Joost, P., Lewerenz, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Analysis of mammalian septin expression in human malignant brain tumors. Kim, D.S., Hubbard, S.L., Peraud, A., Salhia, B., Sakai, K., Rutka, J.T. Neoplasia (2004) [Pubmed]
  3. Expression of septin 3 isoforms in human brain. Takehashi, M., Tanaka, S., Stedeford, T., Banasik, M., Tsukagoshi-Nagai, H., Kinoshita, N., Kawamata, T., Ueda, K. Gene Expr. (2004) [Pubmed]
  4. Septin 3 gene polymorphism in Alzheimer's disease. Takehashi, M., Alioto, T., Stedeford, T., Persad, A.S., Banasik, M., Masliah, E., Tanaka, S., Ueda, K. Gene Expr. (2004) [Pubmed]
  5. Predictors of Tadalafil Efficacy in Men with Erectile Dysfunction: The SURE Study Comparing Two Dosing Regimens. Costa, P., Buvat, J., Holmes, S., Weitckus, S., Petto, H., Hamidi, K., Varanese, L. The journal of sexual medicine (2006) [Pubmed]
  6. Petaloidy and petal identity MADS-box genes in the balsaminoid genera Impatiens and Marcgravia. Geuten, K., Becker, A., Kaufmann, K., Caris, P., Janssens, S., Viaene, T., Theissen, G., Smets, E. Plant J. (2006) [Pubmed]
  7. Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals. Xue, J., Milburn, P.J., Hanna, B.T., Graham, M.E., Rostas, J.A., Robinson, P.J. Biochem. J. (2004) [Pubmed]
  8. Penetration and maintenance of erection with vardenafil: a time-from-dosing analysis. Valiquette, L., Montorsi, F., Hellstrom, W.J., Giuliano, F., Homering, M., Taylor, T., Eardley, I. The Canadian journal of urology. (2005) [Pubmed]
  9. Comparison of efficacy, safety, and tolerability of on-demand tadalafil and daily dosed tadalafil for the treatment of erectile dysfunction. McMahon, C. The journal of sexual medicine. (2005) [Pubmed]
  10. The efficacy and safety of flexible-dose vardenafil (levitra) in a broad population of European men. Hatzichristou, D., Montorsi, F., Buvat, J., Laferriere, N., Bandel, T.J., Porst, H. Eur. Urol. (2004) [Pubmed]
  11. Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study. Zinner, N. The journal of sexual medicine (2007) [Pubmed]
  12. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. She, Y.M., Huang, Y.W., Zhang, L., Trimble, W.S. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
 
WikiGenes - Universities