Disease relevance of CEACAM19

• CEAL1 is highly expressed in BT-474, BT20, T47D and, at much lower levels, in MCF7 breast cancer cell lines [1].
• Immunologic and biochemical studies on the carcinoembryonic antigen-like substance in human neuroblastoma [2].
• Urinary carcinoembryonic antigen-like activity was increased (more than 1.5 ng. per ml.) in 61 per cent of patients with transitional cell carcinoma of the bladder [3].
• Carcinoembryonic antigen-like reactivity in malignant mesothelioma. A comparison between different commercially available antibodies [4].
• Carcinoembryonic antigen like antigen in granular cell myoblastomas. An immunohistochemical study [5].

High impact information on CEACAM19

• Carcinoembryonic antigen-like substance, previously detected in large amounts in the medium from cultures of human prostatic epithelial cells, also is present in extracts of benign and malignant human prostate [6].
• By column chromatography, the prostate-derived carcinoembryonic antigen-like substance derived from cultured prostate is the same as that in tissue extracts and is distinctly different from colon-derived carcinoembryonic antigen [6].
• Amino-terminal sequence of a carcinoembryonic antigen-like glycoprotein isolated from the colonic lavages of healthy individuals [7].
• Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation [8].
• The CEAL1 gene was found to be down-regulated by dexamethasone in BT-474 breast cancer cell lines [1].

Biological context of CEACAM19

• Through the positional cloning approach we have identified and characterized a CEA-like gene (CEAL1), a novel member of the CEA multigene family [1].
• Homogeneous cell growth and morphology have been maintained for over 18 months through more than 80 subculture passages, and the cells have been found to produce both immunoreactive calcitonin and an immunoreactive carcinoembryonic antigen-like material [9].

Anatomical context of CEACAM19

• CEAL1 mRNA is expressed in a variety of tissues, but highest levels are found in the prostate, uterus, fetal brain, mammary, adrenal gland, skeletal muscle, small intestine and kidney [1].
• Carcinoembryonic antigen-like activity in gastric juice and plasma in patients with gastric disorders [10].
• These data suggest that the CEA-like material is normally secreted into the gastrointestinal tract and particularly into the colon [11].
• Specimens of pre- and postpubertal and adult prostatic tissue and seminal vesicles were examined for the presence of carcinoembryonic antigen-like immunoreactivity [12].

Associations of CEACAM19 with chemical compounds

• After perchloric acid extraction, the CEA-like material from the colon had the same chromatographic and radioimmunologic properties as [125I] CEA [11].

Analytical, diagnostic and therapeutic context of CEACAM19

• Isolation and immunochemical and chemical characterization of carcinoembryonic antigen-like substances in colon lavages of healthy individuals [13].
• 6. NB/70K does not appear to contain normal serum, normal ovary, normal lung, or carcinoembryonic antigen-like cross-reacting antigenic determinants as measured by radioimmunoassay [14].
• A carcinoembryonic antigen-like antigen(s) (CELIA) was isolated from normal human gastric jucie by immunoadsorbents and gel chromatography [15].
• The secretion of carcinoembryonic antigen-like (CEA-like) material into the gastrointestinal tract of 28 fasting normal men was quantified by using intestinal perfusion techniques [11].

References