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Gene Review

CEACAM19  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CEAL1, Carcinoembryonic antigen-like 1, Carcinoembryonic antigen-related cell adhesion molecule 19, UNQ2973/PRO7436
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Disease relevance of CEACAM19


High impact information on CEACAM19


Biological context of CEACAM19

  • Through the positional cloning approach we have identified and characterized a CEA-like gene (CEAL1), a novel member of the CEA multigene family [1].
  • Homogeneous cell growth and morphology have been maintained for over 18 months through more than 80 subculture passages, and the cells have been found to produce both immunoreactive calcitonin and an immunoreactive carcinoembryonic antigen-like material [9].

Anatomical context of CEACAM19


Associations of CEACAM19 with chemical compounds

  • After perchloric acid extraction, the CEA-like material from the colon had the same chromatographic and radioimmunologic properties as [125I] CEA [11].

Analytical, diagnostic and therapeutic context of CEACAM19


  1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. Scorilas, A., Chiang, P.M., Katsaros, D., Yousef, G.M., Diamandis, E.P. Gene (2003) [Pubmed]
  2. Immunologic and biochemical studies on the carcinoembryonic antigen-like substance in human neuroblastoma. Sugimoto, T., Sawada, T., Kusunoki, T. Pediatr. Res. (1979) [Pubmed]
  3. Clinical evaluation of urinary and serum carcinoembryonic antigen in bladder cancer. Fraser, R.A., Ravry, M.J., Segura, J.W., Go, V.L. J. Urol. (1975) [Pubmed]
  4. Carcinoembryonic antigen-like reactivity in malignant mesothelioma. A comparison between different commercially available antibodies. Dejmek, A., Hjerpe, A. Cancer (1994) [Pubmed]
  5. Carcinoembryonic antigen like antigen in granular cell myoblastomas. An immunohistochemical study. Nielsen, K., Paulsen, S.M., Johansen, P. Virchows Archiv. A, Pathological anatomy and histopathology. (1983) [Pubmed]
  6. Carcinoembryonic antigen-like substance derived from human prostate. Williams, R.D., Bronson, D.L., Myl, A.D., Vandevoorde, J.P., Elliott, A.Y. Cancer Res. (1979) [Pubmed]
  7. Amino-terminal sequence of a carcinoembryonic antigen-like glycoprotein isolated from the colonic lavages of healthy individuals. Shively, J.E., Todd, C.W., Go, V.L., Egan, M.L. Cancer Res. (1978) [Pubmed]
  8. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. Kuijpers, T.W., van der Schoot, C.E., Hoogerwerf, M., Roos, D. J. Immunol. (1993) [Pubmed]
  9. Immunoreactive calcitonin production by human lung carcinoma cells in culture. Ellison, M., Woodhouse, D., Hillyard, C., Dowsett, M., Coombes, R.C., Gilby, E.D., Greenberg, P.B., Neville, A.M. Br. J. Cancer (1975) [Pubmed]
  10. Carcinoembryonic antigen-like activity in gastric juice and plasma in patients with gastric disorders. Satake, K., Yamashita, K., Kitamura, T., Tei, Y., Umeyama, K. Am. J. Surg. (1980) [Pubmed]
  11. Quantification of carcinoembryonic antigen-like activities in normal, human gastrointestinal secretions. Go, V.L., Ammon, H.V., Holtermuller, K.H., Krag, E., Phillips, S.F. Cancer (1975) [Pubmed]
  12. Carcinoembryonic antigen-like substance is a marker of prostatic secretory function. Aumüller, G., Krause, W., Bischof, W., Seitz, J. Andrologia (1983) [Pubmed]
  13. Isolation and immunochemical and chemical characterization of carcinoembryonic antigen-like substances in colon lavages of healthy individuals. Egan, M.L., Pritchard, D.G., Todd, C.W., Go, V.L. Cancer Res. (1977) [Pubmed]
  14. Identification, purification, and radioimmunoassay of NB/70K, a human ovarian tumor-associated antigen. Knauf, S., Urbach, G.I. Cancer Res. (1981) [Pubmed]
  15. Isolation from human gastric juice of an antigen closely related to the carcinoembryonic antigen. Vuento, M., Engvall, E., Seppälä, M., Ruoslahti, E. Int. J. Cancer (1976) [Pubmed]
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