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Gene Review

CEACAM8  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CD66b, CD67, CD67 antigen, CGM6, Carcinoembryonic antigen CGM6, ...
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Disease relevance of CEACAM8


High impact information on CEACAM8

  • Using OpaI as the prototype, the relative ability of the transfected HeLa cell lines to support adherence was (CEA = BGPa >CGM1a >NCA >>CGM6 = Neo) [6].
  • We also compared the adherence and invasion by Opa+ bacteria of CD66 transfected HeLa cells: HeLa-BGPa, HeLa-CGM6, HeLa-NCA, HeLa-CGM1a, HeLa-CEA, and HeLa-Neo serving as negative control [6].
  • In addition, forced expression of C/EBPepsilon in the U937 myelomonoblastic leukemia cells mimicked terminal granulocytic differentiation, including morphologic changes, increased CD11b/CD66b expression, and induction of secondary granule protein expression [7].
  • Because NCA-95 and NCA-90 have previously been found to be phosphatidylinositol (PI)-linked, paroxysmal nocturnal hemoglobinuria (PNH) neutrophils (which lack PI-linked surface proteins) were tested as well [8].
  • We found that the expression of the membrane antigens CD64, CD66, and CD67 by granulocytes was inversely associated with the luminal renarrowing normalized for vessel size (relative loss) at 6 months after PTCA, while the production of IL-1 beta by stimulated monocytes was positively associated with the relative loss [9].

Chemical compound and disease context of CEACAM8

  • Consistent with the hypothesis, the HIV-1 protease inhibitors enhanced the ability of ATRA to inhibit growth and induce differentiation of HL-60 and NB4 myeloid leukemia cells, as measured by expression of CD11b and CD66b cell surface antigens, as well as reduction of nitroblue tetrazolium [10].
  • However, their cells had a normal expression of other phosphatidylinositol (PI)-linked membrane glycoprotein (CD24, CD67, and CLB gran/5 antigens), ruling out the existence of a PI-linkage defect, such as paroxysmal nocturnal hemoglobinuria [11].
  • Immunoscintigraphy with a technetium-99m murine monoclonal IgG1 antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body [12].

Biological context of CEACAM8


Anatomical context of CEACAM8


Associations of CEACAM8 with chemical compounds

  • Ligation of CGM6 or NCA90 alone did not cause activation of the neutrophil in any of the assays used and did not cause priming of fMLP-induced oxidant production even when a secondary cross-linking reagent was used [20].
  • In addition, associated tyrosine kinase activity may play a role in signal transduction from CD66a, CD66b, and CD66c to regulate other cell functions [21].
  • All samples of synovial fluid PMN exhibited an additional increase in the expression of CD66a, CD66b, and CD66c when stimulated with phorbol myristate acetate in vitro [22].
  • Reduced technetium 99m labelled NCA-95/CEA-antibody uptake in liver due to gentle antibody reconstitution. Technical note [23].
  • On the basis of previous work with various monoclonal antibodies (Mab) raised against carcino-embryonic antigen (CEA), the anti-CEA Mab 47 was identified which selectively reacted with a surface glycoprotein (95 kDa; NCA 95) of normal human granulocytes [24].

Physical interactions of CEACAM8

  • The CEACAM1/CEACAM8 complex in human cells might accordingly play a similar role as CEACAM1-L/CEACAM1-S dimers known to occur in rat cells [17].

Regulatory relationships of CEACAM8


Other interactions of CEACAM8


Analytical, diagnostic and therapeutic context of CEACAM8


  1. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. Kuijpers, T.W., van der Schoot, C.E., Hoogerwerf, M., Roos, D. J. Immunol. (1993) [Pubmed]
  2. CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients. Grunert, F., Daniel, S., Nagel, G., von Kleist, S., Jantscheff, P. Int. J. Cancer (1995) [Pubmed]
  3. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Berling, B., Kolbinger, F., Grunert, F., Thompson, J.A., Brombacher, F., Buchegger, F., von Kleist, S., Zimmermann, W. Cancer Res. (1990) [Pubmed]
  4. Ductal adenocarcinoma of the head of the pancreas: incidence of tumor involvement beyond the Whipple resection line. Histological and immunocytochemical analysis of 37 total pancreatectomy specimens. Klöppel, G., Lohse, T., Bosslet, K., Rückert, K. Pancreas (1987) [Pubmed]
  5. Monoclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and nonneoplastic duct lesions as well as nonduct type neoplasias. Bätge, B., Bosslet, K., Sedlacek, H.H., Kern, H.F., Klöppel, G. Virchows Archiv. A, Pathological anatomy and histopathology. (1986) [Pubmed]
  6. Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. Chen, T., Grunert, F., Medina-Marino, A., Gotschlich, E.C. J. Exp. Med. (1997) [Pubmed]
  7. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. Park, D.J., Chumakov, A.M., Vuong, P.T., Chih, D.Y., Gombart, A.F., Miller, W.H., Koeffler, H.P. J. Clin. Invest. (1999) [Pubmed]
  8. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. Kuijpers, T.W., Hoogerwerf, M., van der Laan, L.J., Nagel, G., van der Schoot, C.E., Grunert, F., Roos, D. J. Cell Biol. (1992) [Pubmed]
  9. Late lumen loss after coronary angioplasty is associated with the activation status of circulating phagocytes before treatment. Pietersma, A., Kofflard, M., de Wit, L.E., Stijnen, T., Koster, J.F., Serruys, P.W., Sluiter, W. Circulation (1995) [Pubmed]
  10. HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells. Ikezoe, T., Daar, E.S., Hisatake, J., Taguchi, H., Koeffler, H.P. Blood (2000) [Pubmed]
  11. Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. Huizinga, T.W., Kuijpers, R.W., Kleijer, M., Schulpen, T.W., Cuypers, H.T., Roos, D., von dem Borne, A.E. Blood (1990) [Pubmed]
  12. Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. Munz, D.L., Morguet, A.J., Sandrock, D., Heim, A., Sold, G., Figulla, H.R., Kreuzer, H., Emrich, D. European journal of nuclear medicine. (1991) [Pubmed]
  13. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. Kuroki, M., Abe, H., Imakiirei, T., Liao, S., Uchida, H., Yamauchi, Y., Oikawa, S., Kuroki, M. J. Leukoc. Biol. (2001) [Pubmed]
  14. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. Zhao, L., Xu, S., Peterson, C., Kuroki, M., Kuroki, M., Venge, P. J. Immunol. Methods (2002) [Pubmed]
  15. Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family. Paxton, R.J., Mooser, G., Pande, H., Lee, T.D., Shively, J.E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  16. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Eades-Perner, A.M., Thompson, J., van der Putten, H., Zimmermann, W. Blood (1998) [Pubmed]
  17. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. Singer, B.B., Scheffrahn, I., Heymann, R., Sigmundsson, K., Kammerer, R., Obrink, B. J. Immunol. (2002) [Pubmed]
  18. Analysis of heterophilic cell adhesion mediated by CD66b and CD66c using their soluble recombinant proteins. Yamanka, T., Kuroki, M., Matsuo, Y., Matsuoka, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  19. Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin. Hanenberg, H., Baumann, M., Quentin, I., Nagel, G., Grosse-Wilde, H., von Kleist, S., Göbel, U., Burdach, S., Grunert, F. Leukemia (1994) [Pubmed]
  20. CD66: role in the regulation of neutrophil effector function. Stocks, S.C., Ruchaud-Sparagano, M.H., Kerr, M.A., Grunert, F., Haslett, C., Dransfield, I. Eur. J. Immunol. (1996) [Pubmed]
  21. CD66 family members are associated with tyrosine kinase activity in human neutrophils. Skubitz, K.M., Campbell, K.D., Ahmed, K., Skubitz, A.P. J. Immunol. (1995) [Pubmed]
  22. Synovial PMN show a coordinated up-regulation of CD66 molecules. Hönig, M., Peter, H.H., Jantscheff, P., Grunert, F. J. Leukoc. Biol. (1999) [Pubmed]
  23. Reduced technetium 99m labelled NCA-95/CEA-antibody uptake in liver due to gentle antibody reconstitution. Technical note. Reske, S.N., Buell, U. European journal of nuclear medicine. (1990) [Pubmed]
  24. In vivo labelling of granulocytes using 123I-tagged anti-granulocyte antibodies. Seybold, K. Nuclear medicine communications. (1988) [Pubmed]
  25. Increased synovial expression of the adhesion molecules CD66a, CD66b, and CD31 in rheumatoid and osteoarthritis. Szekanecz, Z., Haines, G.K., Harlow, L.A., Shah, M.R., Fong, T.W., Fu, R., Lin, S.J., Koch, A.E. Clin. Immunol. Immunopathol. (1995) [Pubmed]
  26. Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils. Mollinedo, F., Martín-Martín, B., Calafat, J., Nabokina, S.M., Lazo, P.A. J. Immunol. (2003) [Pubmed]
  27. Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins. Ottonello, L., Epstein, A.L., Dapino, P., Barbera, P., Morone, P., Dallegri, F. Blood (1999) [Pubmed]
  28. Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae. Yamanaka, T., Kuroki, M., Kinugasa, T., Matsuo, Y., Matsuoka, Y. Protein Expr. Purif. (1996) [Pubmed]
  29. Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. Stocks, S.C., Albrechtsen, M., Kerr, M.A. Biochem. J. (1990) [Pubmed]
  30. Subcellular localization and mobilization of carcinoembryonic antigen-related cell adhesion molecule 8 in human neutrophils. Zhao, L., Furebring, M., Xu, S., Venge, P. Br. J. Haematol. (2004) [Pubmed]
  31. A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members. Thompson, J., Mössinger, S., Reichardt, V., Engels, U., Beauchemin, N., Kommoss, F., von Kleist, S., Zimmermann, W. Int. J. Cancer (1993) [Pubmed]
  32. Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils. Kuroki, M., Yamanaka, T., Matsuo, Y., Oikawa, S., Nakazato, H., Matsuoka, Y. Immunol. Invest. (1995) [Pubmed]
  33. An enzyme-linked immunosorbent assay for human carcinoembryonic antigen-related cell adhesion molecule 8, a biological marker of granulocyte activities in vivo. Zhao, L., Xu, S., Fjaertoft, G., Pauksen, K., Håkansson, L., Venge, P. J. Immunol. Methods (2004) [Pubmed]
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