The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

MUC3B  -  mucin 3B, cell surface associated

Homo sapiens

Synonyms: Intestinal mucin-3B, MUC-3B, MUC3, MUC3A, Mucin-3B
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MUC3B

  • The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer [1].
  • In exploration of the mechanism of hypoxic regulation of mucin 3 expression, we demonstrated by luciferase assay that the full-length promoter for mouse Mucin 3 (Muc3) is hypoxia-responsive with a 5.08 +/- 1.76-fold induction following 24 h of hypoxia [2].

High impact information on MUC3B


Anatomical context of MUC3B

  • Concomitantly MUC3 protein precursor (approximately 550 kDa) was detected in Caco-2 cells [6].
  • Furthermore, MUC3 mRNA is expressed in a differentiation dependent manner, as is the case for enterocytes [6].
  • However, MUC3 mRNA expression increased in the ileum and colon of these rats [7].
  • We demonstrate by PCR confirmation of microarray data and by avidin blotting of immunoprecipitated human Mucin 3 (MUC3), that surface MUC3 expression is induced in T84 intestinal epithelial cells following exposure to hypoxia [2].

Associations of MUC3B with chemical compounds


Analytical, diagnostic and therapeutic context of MUC3B


  1. The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer. Duncan, T.J., Watson, N.F., Al-Attar, A.H., Scholefield, J.H., Durrant, L.G. World journal of surgical oncology (2007) [Pubmed]
  2. Selective induction of mucin-3 by hypoxia in intestinal epithelia. Louis, N.A., Hamilton, K.E., Canny, G., Shekels, L.L., Ho, S.B., Colgan, S.P. J. Cell. Biochem. (2006) [Pubmed]
  3. Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Ho, S.B., Dvorak, L.A., Moor, R.E., Jacobson, A.C., Frey, M.R., Corredor, J., Polk, D.B., Shekels, L.L. Gastroenterology (2006) [Pubmed]
  4. Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines. Hollingsworth, M.A., Strawhecker, J.M., Caffrey, T.C., Mack, D.R. Int. J. Cancer (1994) [Pubmed]
  5. Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis. Longman, R.J., Poulsom, R., Corfield, A.P., Warren, B.F., Wright, N.A., Thomas, M.G. J. Histochem. Cytochem. (2006) [Pubmed]
  6. The human intestinal cell lines Caco-2 and LS174T as models to study cell-type specific mucin expression. van Klinken, B.J., Oussoren, E., Weenink, J.J., Strous, G.J., Büller, H.A., Dekker, J., Einerhand, A.W. Glycoconj. J. (1996) [Pubmed]
  7. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Amit-Romach, E., Reifen, R., Uni, Z. Int. J. Mol. Med. (2006) [Pubmed]
  8. Alteration in expression of MUC2 and MUC3 mRNA levels in HT29 colonic carcinoma cells. Mack, D.R., Hollingsworth, M.A. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  9. Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. Gum, J.R., Hicks, J.W., Crawley, S.C., Dahl, C.M., Yang, S.C., Roberton, A.M., Kim, Y.S. J. Biol. Chem. (2003) [Pubmed]
  10. Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. O'Hara, A.M., O'Regan, P., Fanning, A., O'Mahony, C., Macsharry, J., Lyons, A., Bienenstock, J., O'Mahony, L., Shanahan, F. Immunology (2006) [Pubmed]
WikiGenes - Universities