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Gene Review:

Glp2r - glucagon-like peptide 2 receptor

Rattus norvegicus

Synonyms: GLP-2 receptor, GLP-2-R, GLP-2R, Glucagon-like peptide 2 receptor

Yusta, B. et al., Lovshin, J.A. et al., Lovshin, J. et al., Lovshin, J. et al., Munroe, D.G. et al., et al.

Tang-Christensen, Vrang, Larsen,

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High impact information on Glp2r

The human GLP-2R gene maps to chromosome 17p13 [1].
GLP-2 analogs that activated GLP-2R signal transduction in vitro displayed intestinotrophic activity in vivo [1].
A 1.5-kilobase fragment of the mouse GLP-2R promoter directed LacZ expression to the gastrointestinal tract and CNS regions in the mouse that exhibited endogenous GLP-2R expression, including the cerebellum, amygdala, hippocampus, and dentate gyrus [2].
Glucagon-like peptide-2 (GLP-2) promotes the expansion of the intestinal epithelium through stimulation of the GLP-2 receptor, a recently identified member of the glucagon-secretin G protein-coupled receptor superfamily [3].
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor [3].

Anatomical context of Glp2r

Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa [4].
GLP-2R mRNA transcripts were localized by in situ hybridization to the hippocampus, hypothalamus, nucleus of the solitary tract, parabrachial nucleus, supramammillary nucleus, and substantia nigra [5].
We identified proglucagon and GLP-2 receptor (GLP-2R) mRNA transcripts by RT-PCR in multiple regions of the developing and adult rat central nervous system [5].
Analysis of GLP-2 receptor expression by RT-PCR demonstrated GLP-2R messenger RNA transcripts in fetal intestine and in neonatal stomach, jejunum, ileum, and colon [6].
The expression of the GLP-2 receptor gene in both cerebral cortex and astrocytes was determined by RT-PCR and Southern blotting [7].

Associations of Glp2r with chemical compounds

In contrast to the widely distributed GLP-1 receptor mRNA, GLP-2 receptor mRNA is exclusively expressed in the compact part of the DMH (DMHc) [8].

Physical interactions of Glp2r

These findings suggest that the GLP-2R may be coupled to activation of mitogenic signaling in heterologous cell types independent of PKA via as yet unidentified downstream mediators of GLP-2 action in vivo [3].

Other interactions of Glp2r

The actions of GLP-2 are mediated by the GLP-2 receptor, a new member of the G protein-coupled receptor superfamily [6].

References

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Munroe, D.G., Gupta, A.K., Kooshesh, F., Vyas, T.B., Rizkalla, G., Wang, H., Demchyshyn, L., Yang, Z.J., Kamboj, R.K., Chen, H., McCallum, K., Sumner-Smith, M., Drucker, D.J., Crivici, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. Lovshin, J., Estall, J., Yusta, B., Brown, T.J., Drucker, D.J. J. Biol. Chem. (2001) [Pubmed]
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor. Yusta, B., Somwar, R., Wang, F., Munroe, D., Grinstein, S., Klip, A., Drucker, D.J. J. Biol. Chem. (1999) [Pubmed]
Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa. Walsh, N.A., Yusta, B., DaCambra, M.P., Anini, Y., Drucker, D.J., Brubaker, P.L. Endocrinology (2003) [Pubmed]
Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Lovshin, J.A., Huang, Q., Seaberg, R., Brubaker, P.L., Drucker, D.J. Endocrinology (2004) [Pubmed]
Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine. Lovshin, J., Yusta, B., Iliopoulos, I., Migirdicyan, A., Dableh, L., Brubaker, P.L., Drucker, D.J. Endocrinology (2000) [Pubmed]
Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes. Velázquez, E., Ruiz-Albusac, J.M., Blázquez, E. Eur. J. Biochem. (2003) [Pubmed]
Glucagon-like peptide containing pathways in the regulation of feeding behaviour. Tang-Christensen, M., Vrang, N., Larsen, P.J. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]

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