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Gene Review

Glp2r  -  glucagon-like peptide 2 receptor

Rattus norvegicus

Synonyms: GLP-2 receptor, GLP-2-R, GLP-2R, Glucagon-like peptide 2 receptor
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High impact information on Glp2r


Anatomical context of Glp2r


Associations of Glp2r with chemical compounds


Physical interactions of Glp2r

  • These findings suggest that the GLP-2R may be coupled to activation of mitogenic signaling in heterologous cell types independent of PKA via as yet unidentified downstream mediators of GLP-2 action in vivo [3].

Other interactions of Glp2r

  • The actions of GLP-2 are mediated by the GLP-2 receptor, a new member of the G protein-coupled receptor superfamily [6].


  1. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Munroe, D.G., Gupta, A.K., Kooshesh, F., Vyas, T.B., Rizkalla, G., Wang, H., Demchyshyn, L., Yang, Z.J., Kamboj, R.K., Chen, H., McCallum, K., Sumner-Smith, M., Drucker, D.J., Crivici, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. Lovshin, J., Estall, J., Yusta, B., Brown, T.J., Drucker, D.J. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor. Yusta, B., Somwar, R., Wang, F., Munroe, D., Grinstein, S., Klip, A., Drucker, D.J. J. Biol. Chem. (1999) [Pubmed]
  4. Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa. Walsh, N.A., Yusta, B., DaCambra, M.P., Anini, Y., Drucker, D.J., Brubaker, P.L. Endocrinology (2003) [Pubmed]
  5. Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Lovshin, J.A., Huang, Q., Seaberg, R., Brubaker, P.L., Drucker, D.J. Endocrinology (2004) [Pubmed]
  6. Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine. Lovshin, J., Yusta, B., Iliopoulos, I., Migirdicyan, A., Dableh, L., Brubaker, P.L., Drucker, D.J. Endocrinology (2000) [Pubmed]
  7. Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes. Velázquez, E., Ruiz-Albusac, J.M., Blázquez, E. Eur. J. Biochem. (2003) [Pubmed]
  8. Glucagon-like peptide containing pathways in the regulation of feeding behaviour. Tang-Christensen, M., Vrang, N., Larsen, P.J. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
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