Gene Review:
GLP2R - glucagon-like peptide 2 receptor
Homo sapiens
Synonyms:
GLP-2 receptor, GLP-2-R, GLP-2R, Glucagon-like peptide 2 receptor
- The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways. Koehler, J.A., Yusta, B., Drucker, D.J. Mol. Endocrinol. (2005)
- Glucagon and glucagon-like peptide receptors as drug targets. Estall, J.L., Drucker, D.J. Curr. Pharm. Des. (2006)
- GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Guan, X., Karpen, H.E., Stephens, J., Bukowski, J.T., Niu, S., Zhang, G., Stoll, B., Finegold, M.J., Holst, J.J., Hadsell, D., Hadsell, D.L., Nichols, B.L., Burrin, D.G. Gastroenterology (2006)
- Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, R., Sharma, S., Demchyshyn, L., Asa, S.L., Drucker, D.J. Gastroenterology (2000)
- The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. Estall, J.L., Koehler, J.A., Yusta, B., Drucker, D.J. J. Biol. Chem. (2005)
- Biological actions and therapeutic potential of the glucagon-like peptides. Drucker, D.J. Gastroenterology (2002)
- The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway. Yusta, B., Boushey, R.P., Drucker, D.J. J. Biol. Chem. (2000)
- Lipid raft-dependent glucagon-like peptide-2 receptor trafficking occurs independently of agonist-induced desensitization. Estall, J.L., Yusta, B., Drucker, D.J. Mol. Biol. Cell (2004)
- Structural determinants for activity of glucagon-like peptide-2. DaCambra, M.P., Yusta, B., Sumner-Smith, M., Crivici, A., Drucker, D.J., Brubaker, P.L. Biochemistry (2000)
- The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. Thulesen, J., Knudsen, L.B., Hartmann, B., Hastrup, S., Kissow, H., Jeppesen, P.B., Ørskov, C., Holst, J.J., Poulsen, S.S. Regul. Pept. (2002)
- Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Brubaker, P.L., Drucker, D.J. Endocrinology (2004)
- Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor. Boushey, R.P., Yusta, B., Drucker, D.J. Cancer Res. (2001)
- Glucagon-like peptide 2. Drucker, D.J. J. Clin. Endocrinol. Metab. (2001)
- Glucagon-like peptide 2: a nutrient-responsive gut growth factor. Burrin, D.G., Petersen, Y., Stoll, B., Sangild, P. J. Nutr. (2001)
- Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines. Sams, A., Hastrup, S., Andersen, M., Thim, L. Eur. J. Pharmacol. (2006)