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Gene Review

Glp1r  -  glucagon-like peptide 1 receptor

Rattus norvegicus

Synonyms: GLP-1 receptor, GLP-1-R, GLP-1R, Glip, Glpr, ...
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Disease relevance of Glp1r

  • Additionally, an equal level of GLP-1 receptor gene expressions between left- and right-side ganglia was evidenced by semi-quantitative RT-PCR, implying possible extrahepatic occurrence of vagal GLP-1 reception in addition to the reception through the hepatic vagus (originating from the left-side ganglion) [1].
  • A GLP-1R antagonist significantly reduced insulin secretion/production in beta-TC-6 insulinoma cells and isolated rat islets, suggesting a functionally important loop between locally produced GLP-1 and its cognate receptor [2].
  • We here report that repeated intracerebroventricular (i.c.v.) injection of GLP-1 or the GLP-1 receptor antagonist, exendin-(9-39), affects food intake and body weight [3].
  • These results indicate that the GLP-1 pathways in the central nervous system controlling food consumption do not desensitize after chronic exposure to GLP-1 and suggest that agonists of the central GLP-1 receptor may be effective agents for the treatment of obesity [4].
  • We report on the effects of GLP-1 and two of its long-acting analogs, exendin-4 and exendin-4 WOT, on neuronal proliferation and differentiation, and on the metabolism of two neuronal proteins in the rat pheochromocytoma (PC12) cell line, which has been shown to express the GLP-1 receptor [5].
  • Results demonstrate that caudal brainstem processing is sufficient for mediating the suppression of intake, core temperature, and gastric emptying rates as well as tachycardia triggered by peripheral GLP-1R activation and also hindbrain-delivered ligand [6].

Psychiatry related information on Glp1r


High impact information on Glp1r


Chemical compound and disease context of Glp1r

  • In gastric fistula rats, vagal afferent denervation and peripheral administration of the GLP-1 receptor antagonist exendin-(9-39) amide enhanced emptying of a glucose meal, whereas intracerebroventricular exendin was ineffective [12].

Biological context of Glp1r


Anatomical context of Glp1r


Associations of Glp1r with chemical compounds


Physical interactions of Glp1r

  • It is, however, unknown whether oxyntomodulin and GLP-2 elicit a biological response by interacting with the GLP-1 receptor [20].

Regulatory relationships of Glp1r

  • These results indicate that the expression of glucagon and GLP-1 receptor mRNA is differentially regulated in rat pancreatic islets and suggest that regulation of receptor mRNA expression may be an important mechanism for controlling the sensitivity of the islets to glucagon and GLP-1 [16].
  • In this study, we found that many tyrosine hydroxylase (TH)-containing neurons in the AP expressed GLP-1Rs and Fos-IR after intravenous GLP-1R agonists [13].

Other interactions of Glp1r


Analytical, diagnostic and therapeutic context of Glp1r


  1. Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Nakagawa, A., Satake, H., Nakabayashi, H., Nishizawa, M., Furuya, K., Nakano, S., Kigoshi, T., Nakayama, K., Uchida, K. Autonomic neuroscience : basic & clinical. (2004) [Pubmed]
  2. Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function. Masur, K., Tibaduiza, E.C., Chen, C., Ligon, B., Beinborn, M. Mol. Endocrinol. (2005) [Pubmed]
  3. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Meeran, K., O'Shea, D., Edwards, C.M., Turton, M.D., Heath, M.M., Gunn, I., Abusnana, S., Rossi, M., Small, C.J., Goldstone, A.P., Taylor, G.M., Sunter, D., Steere, J., Choi, S.J., Ghatei, M.A., Bloom, S.R. Endocrinology (1999) [Pubmed]
  4. Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats. Davis, H.R., Mullins, D.E., Pines, J.M., Hoos, L.M., France, C.F., Compton, D.S., Graziano, M.P., Sybertz, E.J., Strader, C.D., Van Heek, M. Obes. Res. (1998) [Pubmed]
  5. A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. Perry, T., Lahiri, D.K., Chen, D., Zhou, J., Shaw, K.T., Egan, J.M., Greig, N.H. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  6. Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Hayes, M.R., Skibicka, K.P., Grill, H.J. Endocrinology (2008) [Pubmed]
  7. Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats. Schick, R.R., Zimmermann, J.P., vorm Walde, T., Schusdziarra, V. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  8. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. During, M.J., Cao, L., Zuzga, D.S., Francis, J.S., Fitzsimons, H.L., Jiao, X., Bland, R.J., Klugmann, M., Banks, W.A., Drucker, D.J., Haile, C.N. Nat. Med. (2003) [Pubmed]
  9. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Tang-Christensen, M., Larsen, P.J., Thulesen, J., Rømer, J., Vrang, N. Nat. Med. (2000) [Pubmed]
  10. A role for glucagon-like peptide-1 in the central regulation of feeding. Turton, M.D., O'Shea, D., Gunn, I., Beak, S.A., Edwards, C.M., Meeran, K., Choi, S.J., Taylor, G.M., Heath, M.M., Lambert, P.D., Wilding, J.P., Smith, D.M., Ghatei, M.A., Herbert, J., Bloom, S.R. Nature (1996) [Pubmed]
  11. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Yamamoto, H., Lee, C.E., Marcus, J.N., Williams, T.D., Overton, J.M., Lopez, M.E., Hollenberg, A.N., Baggio, L., Saper, C.B., Drucker, D.J., Elmquist, J.K. J. Clin. Invest. (2002) [Pubmed]
  12. Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. Imeryüz, N., Yeğen, B.C., Bozkurt, A., Coşkun, T., Villanueva-Peñacarrillo, M.L., Ulusoy, N.B. Am. J. Physiol. (1997) [Pubmed]
  13. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. Yamamoto, H., Kishi, T., Lee, C.E., Choi, B.J., Fang, H., Hollenberg, A.N., Drucker, D.J., Elmquist, J.K. J. Neurosci. (2003) [Pubmed]
  14. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Thorens, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  15. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P.A., Drucker, D.J. J. Biol. Chem. (2003) [Pubmed]
  16. Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids. Abrahamsen, N., Nishimura, E. Endocrinology (1995) [Pubmed]
  17. Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Chepurny, O.G., Holz, G.G. Cell Tissue Res. (2002) [Pubmed]
  18. Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung. Lankat-Buttgereit, B., Göke, R., Fehmann, H.C., Richter, G., Göke, B. Exp. Clin. Endocrinol. (1994) [Pubmed]
  19. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Bose, A.K., Mocanu, M.M., Carr, R.D., Brand, C.L., Yellon, D.M. Diabetes (2005) [Pubmed]
  20. Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2. Schepp, W., Dehne, K., Riedel, T., Schmidtler, J., Schaffer, K., Classen, M. Digestion (1996) [Pubmed]
  21. Expression levels of genes likely involved in glucose-sensing in the obese Zucker rat brain. Bogacka, I., Roane, D.S., Xi, X., Zhou, J., Li, B., Ryan, D.H., Martin, R.J. Nutritional neuroscience. (2004) [Pubmed]
  22. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. Navarro, M., Rodriquez de Fonseca, F., Alvarez, E., Chowen, J.A., Zueco, J.A., Gomez, R., Eng, J., Blázquez, E. J. Neurochem. (1996) [Pubmed]
  23. The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. Seeley, R.J., Blake, K., Rushing, P.A., Benoit, S., Eng, J., Woods, S.C., D'Alessio, D. J. Neurosci. (2000) [Pubmed]
  24. Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: effect of GLP-1(7-36)amide on vasopressin and oxytocin release. Zueco, J.A., Esquifino, A.I., Chowen, J.A., Alvarez, E., Castrillón, P.O., Blázquez, E. J. Neurochem. (1999) [Pubmed]
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