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Gene Review

GOUT1  -  gout susceptibility 1

Homo sapiens

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Disease relevance of GOUT1

  • Crystal-induced arthropathy. Gout and pseudogout [1].
  • Letter: Gout and hypothyroidism in males [2].
  • OBJECTIVE: Gout affects a large fraction of persons with advanced chronic kidney disease, and hyperuricemia may increase the risk of cardiovascular disease [3].
  • OBJECTIVE: Gout is a less commonly diagnosed rheumatic disease in China compared with Western countries, but its prevalence appears to be climbing [4].
  • BACKGROUND: Gout is associated with increased body weight [5].

Psychiatry related information on GOUT1

  • SUMMARY: Gout incidence and severity appear to be increasing likely in relation to dietary habits [6].

High impact information on GOUT1

  • 3. In cell-attached patches addition of 100 microM strophanthidin to the bath increased both Gout and Gin [7].
  • CONCLUSION: Gout in women had a later onset and higher frequency of upper limb joint involvement in comparison to men [8].
  • An Unusual Cause of Renal Amyloidosis Secondary to Gout-the First Description of Familial Occurrence [9].
  • BACKGROUND: Gout, an inflammatory arthritis, reportedly afflicts more than 2 million men and women in the United States. Previous reports have suggested an association between gout and kidney stone disease; however, these studies did not adjust for such important potential confounders as obesity and the presence of hypertension [10].
  • BACKGROUND: Gout is a common and challenging problem in South Auckland, New Zealand. Allopurinol is widely used but urate reduction remains unsatisfactory [11].

Biological context of GOUT1


Anatomical context of GOUT1

  • Case report 178: Gout affecting the tarsal and metatarsal bones of the left foot and right hand [13].
  • Case report 732. Gout presenting as a large pseudo tumor (tophus) in the proximal end of the tibia [14].

Associations of GOUT1 with chemical compounds


Analytical, diagnostic and therapeutic context of GOUT1

  • RESULTS: Gout medication errors occurred in 39% (n = 273) of facilities participating in the MEDMARX program [16].


  1. Crystal-induced arthropathy. Gout and pseudogout. Resnick, D. JAMA (1979) [Pubmed]
  2. Letter: Gout and hypothyroidism in males. Durward, W.F. Arthritis Rheum. (1976) [Pubmed]
  3. Effects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: a randomized clinical trial. Garg, J.P., Chasan-Taber, S., Blair, A., Plone, M., Bommer, J., Raggi, P., Chertow, G.M. Arthritis Rheum. (2005) [Pubmed]
  4. The management of gout at an academic healthcare center in beijing: a physician survey. Fang, W., Zeng, X., Li, M., Chen, L.X., Schumacher, H.R., Zhang, F. J. Rheumatol. (2006) [Pubmed]
  5. Development of acute gouty attack in the morbidly obese population after bariatric surgery. Antozzi, P., Soto, F., Arias, F., Carrodeguas, L., Ropos, T., Zundel, N., Szomstein, S., Rosenthal, R. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2005) [Pubmed]
  6. Gout. Pascual, E., Pedraz, T. Current opinion in rheumatology. (2004) [Pubmed]
  7. An intracellular ATP-activated, calcium-permeable conductance on the basolateral membrane of single renal proximal tubule cells isolated from Rana temporaria. Robson, L., Hunter, M. J. Physiol. (Lond.) (2000) [Pubmed]
  8. Female gout: clinical and laboratory features. De Souza, A.W., Fernandes, V., Ferrari, A.J. J. Rheumatol. (2005) [Pubmed]
  9. An Unusual Cause of Renal Amyloidosis Secondary to Gout-the First Description of Familial Occurrence. Vernerov??, Z., Rychl??k, I., Brunerov??, L., Dvor??kov??, L., Pavelkov??, A., Sebesta, I. Nucleosides Nucleotides Nucleic Acids (2006) [Pubmed]
  10. The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994. Kramer, H.M., Curhan, G. Am. J. Kidney Dis. (2002) [Pubmed]
  11. The optimal use of allopurinol: an audit of allopurinol use in South Auckland. Stamp, L., Gow, P., Sharples, K., Raill, B. Australian and New Zealand journal of medicine. (2000) [Pubmed]
  12. ABC of rheumatology. Gout, hyperuricaemia, and crystal arthritis. Snaith, M.L. BMJ (1995) [Pubmed]
  13. Case report 178: Gout affecting the tarsal and metatarsal bones of the left foot and right hand. Lacey, P.G., Harrison, R.B. Skeletal radiology. (1981) [Pubmed]
  14. Case report 732. Gout presenting as a large pseudo tumor (tophus) in the proximal end of the tibia. Cope, R., Marsan, R., Castelli, M.J. Skeletal radiology. (1992) [Pubmed]
  15. A structural approach to pathological crystallizations. Gout: the possible role of albumin in sodium urate crystallization. Perl-Treves, D., Addadi, L. Proc. R. Soc. Lond., B, Biol. Sci. (1988) [Pubmed]
  16. Medication errors with the use of allopurinol and colchicine: a retrospective study of a national, anonymous Internet-accessible error reporting system. Mikuls, T.R., Curtis, J.R., Allison, J.J., Hicks, R.W., Saag, K.G. J. Rheumatol. (2006) [Pubmed]
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