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Gene Review

Etohc1  -  ethanol consumption 1

Mus musculus

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Disease relevance of Etohc1


Psychiatry related information on Etohc1


High impact information on Etohc1


Chemical compound and disease context of Etohc1


Biological context of Etohc1


Anatomical context of Etohc1


Associations of Etohc1 with chemical compounds

  • Ethanol consumption increased the frequency of chromosomal damage, but no differences in the effect of ethanol between mice fed with the normal diet and mice fed with the hypoproteic diet (16.33 and 16.80 dicentrics per 100 cells respectively) [21].
  • After 6 months of ethanol consumption we have observed in mouse liver an increased expression of Tri-iodothyronine receptors (TR) while the expression of retinoic acid (RA) receptors (RAR) was unaffected [26].
  • Data indicate that iron deficiency and/or chronic ethanol consumption induce adverse effects on maternal reproductive performance of CBA/J mice possibly via alteration of folate metabolism [27].
  • After chronic ethanol consumption, microsomal ethanol-oxidizing system (MEOS) activity increases with an associated rise in microsomal cytochrome P-450, including a form different from that induced by phenobarbital and methylcholanthrene and which has a high affinity for ethanol, as shown in reconstituted systems [28].
  • The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism [29].

Physical interactions of Etohc1


Regulatory relationships of Etohc1

  • Here we show that chronic ethanol consumption induces significant apoptosis in the liver of IL-6 (-/-) mice but not IL-6 (+/+) mice [31].
  • BACKGROUND: Recent genetic and pharmacological evidence indicates that low neuropeptide Y (NPY) levels in brain regions involved with neurobiological responses to ethanol promote increased ethanol consumption [32].
  • In this study we determined, first, whether acute tolerance to ethanol inhibition is mediated via NR2B-containing NMDARs in vivo and, second, whether the increase in acute sensitivity to ethanol in the Fyn-/- mice influences ethanol consumption or ethanol's conditioned rewarding effects [33].
  • Ethanol consumption suppresses the IL2-induced proliferation of NK cells [34].
  • Results from the present study indicate that the gene encoding the neuronal-specific gamma subtype of protein kinase C (PKCgamma) influences both ethanol consumption and behavioral impulsivity, a personality characteristic associated with Type II alcoholics, in a pleiotropic manner [35].

Other interactions of Etohc1


Analytical, diagnostic and therapeutic context of Etohc1


  1. Co-metabolism of ethanol, ethanol-derived acetaldehyde, and 4-hydroxynonenal in isolated rat hepatocytes. Hartley, D.P., Petersen, D.R. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
  2. Ethanol-induced chromosomal abnormalities at conception. Kaufman, M.H. Nature (1983) [Pubmed]
  3. Chronic ethanol effects on cellular immune responses to hepatitis B virus envelope protein: an immunologic mechanism for induction of persistent viral infection in alcoholics. Geissler, M., Gesien, A., Wands, J.R. Hepatology (1997) [Pubmed]
  4. Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice. Tsutsumi, T., Suzuki, T., Moriya, K., Shintani, Y., Fujie, H., Miyoshi, H., Matsuura, Y., Koike, K., Miyamura, T. Hepatology (2003) [Pubmed]
  5. Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids. Geissler, M., Gesien, A., Wands, J.R. J. Immunol. (1997) [Pubmed]
  6. Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1 ( Brdm1 ) mutant mice. Zghoul, T., Abarca, C., Sanchis-Segura, C., Albrecht, U., Schumann, G., Spanagel, R. Psychopharmacology (Berl.) (2007) [Pubmed]
  7. Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. Cowen, M.S., Schroff, K.C., Gass, P., Sprengel, R., Spanagel, R. Neuropharmacology (2003) [Pubmed]
  8. Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism. Cowen, M.S., Krstew, E., Lawrence, A.J. Psychopharmacology (Berl.) (2007) [Pubmed]
  9. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alfos, S., Boucheron, C., Pallet, V., Higueret, D., Enderlin, V., Béracochéa, D., Jaffard, R., Higueret, P. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  10. Modulation of elevated plus maze behavior after chronic exposure to the anabolic steroid 17alpha-methyltestosterone in adult mice. Rojas-Ortiz, Y.A., Rundle-González, V., Rivera-Ramos, I., Jorge, J.C. Hormones and behavior. (2006) [Pubmed]
  11. Increased ethanol resistance and consumption in eps8 knockout mice correlates with altered actin dynamics. Offenh??user, N., Castelletti, D., Mapelli, L., Soppo, B.E., Regondi, M.C., Rossi, P., D'Angelo, E., Frassoni, C., Amadeo, A., Tocchetti, A., Pozzi, B., Disanza, A., Guarnieri, D., Betsholtz, C., Scita, G., Heberlein, U., Di Fiore, P.P. Cell (2006) [Pubmed]
  12. The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Choi, D.S., Cascini, M.G., Mailliard, W., Young, H., Paredes, P., McMahon, T., Diamond, I., Bonci, A., Messing, R.O. Nat. Neurosci. (2004) [Pubmed]
  13. Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Kessova, I.G., Ho, Y.S., Thung, S., Cederbaum, A.I. Hepatology (2003) [Pubmed]
  14. Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross. Bachmanov, A.A., Reed, D.R., Li, X., Li, S., Beauchamp, G.K., Tordoff, M.G. Genome Res. (2002) [Pubmed]
  15. Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice. Walker, R.M., McElligott, T.F., Power, E.M., Massey, T.E., Racz, W.J. Toxicology (1983) [Pubmed]
  16. Magnesium may help patients with recessive hereditary inclusion body myopathy, a pathological review. Darvish, D. Med. Hypotheses (2003) [Pubmed]
  17. Potentiation of chemically induced cleft palate by ethanol ingestion during gestation in the mouse. Lee, M. Teratog., Carcinog. Mutagen. (1985) [Pubmed]
  18. Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Phillips, T.J., Belknap, J.K., Buck, K.J., Cunningham, C.L. Mamm. Genome (1998) [Pubmed]
  19. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Hintz, K.K., Relling, D.P., Saari, J.T., Borgerding, A.J., Duan, J., Ren, B.H., Kato, K., Epstein, P.N., Ren, J. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  20. Chronic ethanol consumption stimulates hepatitis B virus gene expression and replication in transgenic mice. Larkin, J., Clayton, M.M., Liu, J., Feitelson, M.A. Hepatology (2001) [Pubmed]
  21. The effect of a hypoproteic diet and ethanol consumption on the yield of chromosomal damage detected in bone marrow cells of mice. Terreros, M.C., De Luca, J.C., Dulout, F.N. J. Vet. Med. Sci. (1993) [Pubmed]
  22. Chronic ethanol consumption by mice results in activated splenic T cells. Song, K., Coleman, R.A., Zhu, X., Alber, C., Ballas, Z.K., Waldschmidt, T.J., Cook, R.T. J. Leukoc. Biol. (2002) [Pubmed]
  23. Acute and chronic effects of ethanol on transbilayer membrane domains. Wood, W.G., Gorka, C., Schroeder, F. J. Neurochem. (1989) [Pubmed]
  24. Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. Kumar, S., Sieghart, W., Morrow, A.L. J. Neurochem. (2002) [Pubmed]
  25. Oxidation chemistry of the endogenous central nervous system alkaloid salsolinol-1-carboxylic acid. Zhang, F., Dryhurst, G. J. Med. Chem. (1993) [Pubmed]
  26. Chronic ethanol administration enhances retinoic acid and triiodothyronine receptor expression in mouse liver. Pallet, V., Coustaut, M., Naulet, F., Higueret, D., Garcin, H., Higueret, P. FEBS Lett. (1993) [Pubmed]
  27. Effects of chronic alcohol consumption and iron deficiency on maternal folate status and reproductive outcome in mice. El Banna, N., Picciano, M.F., Simon, J. J. Nutr. (1983) [Pubmed]
  28. Microsomal ethanol-oxidizing system. Lieber, C.S. Enzyme (1987) [Pubmed]
  29. The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Olive, M.F., McGeehan, A.J., Kinder, J.R., McMahon, T., Hodge, C.W., Janak, P.H., Messing, R.O. Mol. Pharmacol. (2005) [Pubmed]
  30. Changes in neurotensin receptor binding in mice after chronic ethanol consumption. Campbell, A.D., Erwin, V.G. Ann. N. Y. Acad. Sci. (1992) [Pubmed]
  31. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins. Hong, F., Kim, W.H., Tian, Z., Jaruga, B., Ishac, E., Shen, X., Gao, B. Oncogene (2002) [Pubmed]
  32. Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. Hayes, D.M., Knapp, D.J., Breese, G.R., Thiele, T.E. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  33. Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Yaka, R., Tang, K.C., Camarini, R., Janak, P.H., Ron, D. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  34. Ethanol consumption suppresses the IL2-induced proliferation of NK cells. Gallucci, R.M., Meadows, G.G. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  35. Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice. Bowers, B.J., Wehner, J.M. J. Neurosci. (2001) [Pubmed]
  36. Metabolism of alcohol at high concentrations: role and biochemical nature of the hepatic microsomal ethanol oxidizing system. Teschke, R., Matsuzaki, S., Ohnishi, K., Hasumura, Y., Lieber, C.S. Adv. Exp. Med. Biol. (1977) [Pubmed]
  37. Receptor crosstalk: characterization of mice deficient in dopamine D1 and adenosine A2A receptors. Short, J.L., Ledent, C., Drago, J., Lawrence, A.J. Neuropsychopharmacology (2006) [Pubmed]
  38. Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit. Boyce-Rustay, J.M., Holmes, A. Psychopharmacology (Berl.) (2006) [Pubmed]
  39. From the Cover: Ethanol prevents development of destructive arthritis. Jonsson, I.M., Verdrengh, M., Brisslert, M., Lindblad, S., Bokarewa, M., Islander, U., Carlsten, H., Ohlsson, C., Nandakumar, K.S., Holmdahl, R., Tarkowski, A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  40. Combined effects of moderate ethanol consumption and a low-protein diet during gestation on brain development in BALB/c mice. Wainwright, P., Ward, G.R., Blom, K. Exp. Neurol. (1985) [Pubmed]
  41. Preconditioning with ethanol prevents postischemic leukocyte-endothelial cell adhesive interactions. Yamaguchi, T., Dayton, C., Shigematsu, T., Carter, P., Yoshikawa, T., Gute, D.C., Korthuis, R.J. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  42. Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Gabriel, K.I., Cunningham, C.L. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
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