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Bbox1  -  butyrobetaine (gamma), 2-oxoglutarate...

Rattus norvegicus

Synonyms: Bbh, Bbox, Gamma-BBH, Gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase, ...
 
 
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Disease relevance of Bbox1

 

High impact information on Bbox1

 

Anatomical context of Bbox1

 

Associations of Bbox1 with chemical compounds

 

Other interactions of Bbox1

  • The activity of gamma-butyrobetaine hydroxylase in testes is comparable on a protein basis to the amount of activity found in liver and accounts for a significant amount of the total activity found in the rat [9].
 

Analytical, diagnostic and therapeutic context of Bbox1

References

  1. Thyroid hormone controls carnitine status through modifications of gamma-butyrobetaine hydroxylase activity and gene expression. Galland, S., Georges, B., Le Borgne, F., Conductier, G., Dias, J.V., Demarquoy, J. Cell. Mol. Life Sci. (2002) [Pubmed]
  2. Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction. Hayashi, Y., Kirimoto, T., Asaka, N., Nakano, M., Tajima, K., Miyake, H., Matsuura, N. Eur. J. Pharmacol. (2000) [Pubmed]
  3. Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts. Hayashi, Y., Tajima, K., Kirimoto, T., Miyake, H., Matsuura, N. Pharmacology (2000) [Pubmed]
  4. MET-88, a gamma-butyrobetaine hydroxylase inhibitor, improves cardiac SR Ca2+ uptake activity in rats with congestive heart failure following myocardial infarction. Hayashi, Y., Ishida, H., Hoshiai, M., Hoshiai, K., Kirimoto, T., Kanno, T., Nakano, M., Tajima, K., Miyake, H., Matsuura, N., Nakazawa, H. Mol. Cell. Biochem. (2000) [Pubmed]
  5. gamma-Butyrobetaine hydroxylase and the protective role of glutathione peroxidase. Punekar, N.S., Wehbie, R.S., Lardy, H.A. J. Biol. Chem. (1987) [Pubmed]
  6. gamma-butyrobetaine in tissues and serum of fed and starved rats determined by an enzymic radioisotopic procedure. Noël, H., Parvin, R., Pande, S.V. Biochem. J. (1984) [Pubmed]
  7. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor. Tsoko, M., Beauseigneur, F., Gresti, J., Niot, I., Demarquoy, J., Boichot, J., Bezard, J., Rochette, L., Clouet, P. Biochem. Pharmacol. (1995) [Pubmed]
  8. Molecular cloning and characterization of the cDNA encoding the rat liver gamma-butyrobetaine hydroxylase. Galland, S., Le Borgne, F., Bouchard, F., Georges, B., Clouet, P., Grand-Jean, F., Demarquoy, J. Biochim. Biophys. Acta (1999) [Pubmed]
  9. Localization of gamma-butyrobetaine hydroxylase in the rat testis. Carter, A.L., Abney, T.O., Braver, H., Chuang, A.H. Biol. Reprod. (1987) [Pubmed]
  10. Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium)propionate dihydrate (MET-88), a novel cardioprotective agent, in rats. Yoshisue, K., Yamamoto, Y., Yoshida, K., Saeki, M., Minami, Y., Esumi, Y., Kawaguchi, Y. Drug Metab. Dispos. (2000) [Pubmed]
  11. Effect of 3-(2,2,2-trimethylhydrazinium) propionate, gamma-butyrobetaine hydroxylase inhibitor, on isoproterenol-induced mitochondrial dysfunction. Hanaki, Y., Sugiyama, S., Ozawa, T. Res. Commun. Chem. Pathol. Pharmacol. (1989) [Pubmed]
  12. Clofibrate enhancement of mitochondrial carnitine transport system of rat liver and augmentation of liver carnitine and gamma-butyrobetaine hydroxylase activity by thyroxine. Pande, S.V., Parvin, R. Biochim. Biophys. Acta (1980) [Pubmed]
 
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