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MRPL41  -  mitochondrial ribosomal protein L41

Homo sapiens

Synonyms: 39S ribosomal protein L27 homolog, 39S ribosomal protein L41, mitochondrial, BMRP, Bcl-2-interacting mitochondrial ribosomal protein L41, Cell proliferation-inducing gene 3 protein, ...
 
 
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Disease relevance of MRPL41

  • Therefore, the activation of p53 seems to play a crucial role in copper and zinc induced generation of ROS in epithelial breast cancer cells, and expression of downstream targets of p53, such as PIG3 and Bax, responsible for increased generation of the intracellular ROS, as well as disruption of mitochondrial integrity [1].
  • Loss of heterozygosity of the polymorphic PIG3 microsatellite with low frequency in de novo acute myeloid leukemias [2].
 

High impact information on MRPL41

  • The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression [3].
  • We discovered that MRPL41 protein is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis [4].
  • Interestingly, in the absence of p53, MRPL41 stabilizes the p27(Kip1) protein and arrests the cell cycle at the G1 phase [4].
  • We show here that the replacement of the N-terminal (amino acids 1-80) or C-terminal (amino acids 344-393) domains of p53 with heterologous domains does not interfere with transcription from the PIG3 promoter, but these chimeras still require the proline-rich region for PIG3 activation [5].
  • Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions [6].
 

Biological context of MRPL41

 

Physical interactions of MRPL41

 

Other interactions of MRPL41

 

Analytical, diagnostic and therapeutic context of MRPL41

References

  1. Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Ostrakhovitch, E.A., Cherian, M.G. Apoptosis (2005) [Pubmed]
  2. Loss of heterozygosity of the polymorphic PIG3 microsatellite with low frequency in de novo acute myeloid leukemias. Nomdedéu, J.F., Perea, G., Estivill, C., Lasa, A., Brunet, S., Aventín, A., Sierra, J. Leukemia (2004) [Pubmed]
  3. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. Venot, C., Maratrat, M., Dureuil, C., Conseiller, E., Bracco, L., Debussche, L. EMBO J. (1998) [Pubmed]
  4. Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. Yoo, Y.A., Kim, M.J., Park, J.K., Chung, Y.M., Lee, J.H., Chi, S.G., Kim, J.S., Yoo, Y.D. Mol. Cell. Biol. (2005) [Pubmed]
  5. Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain. Roth, J., Koch, P., Contente, A., Dobbelstein, M. Oncogene (2000) [Pubmed]
  6. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). Kim, M.J., Yoo, Y.A., Kim, H.J., Kang, S., Kim, Y.G., Kim, J.S., Yoo, Y.D. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. BMRP is a Bcl-2 binding protein that induces apoptosis. Chintharlapalli, S.R., Jasti, M., Malladi, S., Parsa, K.V., Ballestero, R.P., González-García, M. J. Cell. Biochem. (2005) [Pubmed]
  8. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. Flatt, P.M., Polyak, K., Tang, L.J., Scatena, C.D., Westfall, M.D., Rubinstein, L.A., Yu, J., Kinzler, K.W., Vogelstein, B., Hill, D.E., Pietenpol, J.A. Cancer Lett. (2000) [Pubmed]
 
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