Gene Review:
Bad - BCL2-associated agonist of cell death
Mus musculus
Synonyms:
AI325008, BAD, Bbc2, Bbc6, Bcl-2-binding component 6, ...
- Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Erler, J.T., Cawthorne, C.J., Williams, K.J., Koritzinsky, M., Wouters, B.G., Wilson, C., Miller, C., Demonacos, C., Stratford, I.J., Dive, C. Mol. Cell. Biol. (2004)
- Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad. Chen, G., Branton, P.E., Yang, E., Korsmeyer, S.J., Shore, G.C. J. Biol. Chem. (1996)
- Cycloheximide and actinomycin D delay death and affect bcl-2, bax, and Ice gene expression in astrocytes under in vitro ischemia. Yu, A.C., Yung, H.W., Hui, M.H., Lau, L.T., Chen, X.Q., Collins, R.A. J. Neurosci. Res. (2003)
- Tacrolimus (FK506) attenuates biphasic cytochrome c release and Bad phosphorylation following transient cerebral ischemia in mice. Li, J.Y., Furuichi, Y., Matsuoka, N., Mutoh, S., Yanagihara, T. Neuroscience (2006)
- Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B., Korsmeyer, S.J. Cell (1995)
- BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Zong, W.X., Lindsten, T., Ross, A.J., MacGregor, G.R., Thompson, C.B. Genes Dev. (2001)
- Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Khaled, A.R., Li, W.Q., Huang, J., Fry, T.J., Khaled, A.S., Mackall, C.L., Muegge, K., Young, H.A., Durum, S.K. Immunity (2002)
- Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR(2)PB. Zhang, Y., Yu, J., Unni, E., Shao, T.C., Nan, B., Snabboon, T., Kasper, S., Andriani, F., Denner, L., Marcelli, M. Hum. Gene Ther. (2002)
- Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. Saito, A., Hayashi, T., Okuno, S., Ferrand-Drake, M., Chan, P.H. J. Neurosci. (2003)
- Extracellular Bad fused to toxin transport domains induces apoptosis. Ichinose, M., Liu, X.H., Hagihara, N., Youle, R.J. Cancer Res. (2002)
- Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Jiang, Q., Li, W.Q., Hofmeister, R.R., Young, H.A., Hodge, D.R., Keller, J.R., Khaled, A.R., Durum, S.K. Mol. Cell. Biol. (2004)
- Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. Solhaug, A., Refsnes, M., Låg, M., Schwarze, P.E., Husøy, T., Holme, J.A. Carcinogenesis (2004)
- Modulation of apoptosis in the mouse brain after morphine treatments and morphine withdrawal. Emeterio, E.P., Tramullas, M., Hurlé, M.A. J. Neurosci. Res. (2006)
- p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Schürmann, A., Mooney, A.F., Sanders, L.C., Sells, M.A., Wang, H.G., Reed, J.C., Bokoch, G.M. Mol. Cell. Biol. (2000)
- Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. Li, W.Q., Jiang, Q., Khaled, A.R., Keller, J.R., Durum, S.K. J. Biol. Chem. (2004)
- Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. Metcalfe, A.D., Gilmore, A., Klinowska, T., Oliver, J., Valentijn, A.J., Brown, R., Ross, A., MacGregor, G., Hickman, J.A., Streuli, C.H. J. Cell. Sci. (1999)
- High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism. Kang, B.P., Frencher, S., Reddy, V., Kessler, A., Malhotra, A., Meggs, L.G. Am. J. Physiol. Renal Physiol. (2003)
- Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Hatano, E., Brenner, D.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- Expression of selected apoptosis related genes, MIF, IGIF and TNF alpha, during retinoic acid-induced neural differentiation in murine embryonic stem cells. Sarkar, S.A., Sharma, R.P. Cell Struct. Funct. (2002)
- Bcl-XL induction during terminal differentiation of friend erythroleukaemia cells correlates with delay of apoptosis and loss of proliferative capacity but not with haemoglobinization. Hafid-Medheb, K., Poindessous-Jazat, V., Augery-Bourget, Y., Hanania, N., Robert-Lézénès, J. Cell Death Differ. (1999)
- Phenotype of genetically regulated thymic involution in young BXD RI strains of mice. Wang, X., Hsu, H.C., Wang, Y., Edwards, C.K., Yang, P., Wu, Q., Mountz, J.D. Scand. J. Immunol. (2006)
- The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Ayllón, V., Cayla, X., García, A., Fleischer, A., Rebollo, A. Eur. J. Immunol. (2002)
- Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. Ayllón, V., Martínez-A, C., García, A., Cayla, X., Rebollo, A. EMBO J. (2000)
- Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. Macdonald, A., Campbell, D.G., Toth, R., McLauchlan, H., Hastie, C.J., Arthur, J.S. BMC Cell Biol. (2006)
- Endogenous c-N-Ras provides a steady-state anti-apoptotic signal. Wolfman, J.C., Wolfman, A. J. Biol. Chem. (2000)
- Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Chan, P.H. Ann. N. Y. Acad. Sci. (2005)
- Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Kelekar, A., Chang, B.S., Harlan, J.E., Fesik, S.W., Thompson, C.B. Mol. Cell. Biol. (1997)
- PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Sun, H., Lesche, R., Li, D.M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X., Wu, H. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. Kaiser, R.A., Liang, Q., Bueno, O., Huang, Y., Lackey, T., Klevitsky, R., Hewett, T.E., Molkentin, J.D. J. Biol. Chem. (2005)
- bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal carcinoma cells during neuronal differentiation. Miho, Y., Kouroku, Y., Fujita, E., Mukasa, T., Urase, K., Kasahara, T., Isoai, A., Momoi, M.Y., Momoi, T. Cell Death Differ. (1999)
- Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. Zhu, Y., Yang, G.Y., Ahlemeyer, B., Pang, L., Che, X.M., Culmsee, C., Klumpp, S., Krieglstein, J. J. Neurosci. (2002)
- v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL. Chen, Q., Turner, J., Watson, A.J., Dive, C. Oncogene (1997)
- Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: regulation by the Bcl-2 protein family. Wildhaber, B.E., Lynn, K.N., Yang, H., Teitelbaum, D.H. Pediatr. Surg. Int. (2002)
- The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt. Rose, A., Froment, P., Perrot, V., Quon, M.J., LeRoith, D., Dupont, J. J. Biol. Chem. (2004)
- Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo. Sawa, H., Murakami, H., Kumagai, M., Nakasato, M., Yamauchi, S., Matsuyama, N., Tamura, Y., Satone, A., Ide, W., Hashimoto, I., Kamada, H. Acta Neuropathol. (2004)
- Bad-dependent rafts alteration is a consequence of an early intracellular signal triggered by interleukin-4 deprivation. Fleischer, A., Ghadiri, A., Dessauge, F., Duhamel, M., Cayla, X., Garcia, A., Rebollo, A. Mol. Cancer Res. (2004)
- Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. Dramsi, S., Scheid, M.P., Maiti, A., Hojabrpour, P., Chen, X., Schubert, K., Goodlett, D.R., Aebersold, R., Duronio, V. J. Biol. Chem. (2002)
- Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Contreras, J.L., Smyth, C.A., Bilbao, G., Young, C.J., Thompson, J.A., Eckhoff, D.E. Transplantation (2002)