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Gene Review

Adamts4  -  ADAM metallopeptidase with thrombospondin...

Rattus norvegicus

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, Aggrecanase-1
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Disease relevance of Adamts4


High impact information on Adamts4


Biological context of Adamts4


Anatomical context of Adamts4


Other interactions of Adamts4

  • One subtracted gene that showed the Abeta-induced expression was rat ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) [7].
  • 3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase [8].

Analytical, diagnostic and therapeutic context of Adamts4


  1. Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Xiang, J.S., Hu, Y., Rush, T.S., Thomason, J.R., Ipek, M., Sum, P.E., Abrous, L., Sabatini, J.J., Georgiadis, K., Reifenberg, E., Majumdar, M., Morris, E.A., Tam, S. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  2. Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes. Hamel, M.G., Mayer, J., Gottschall, P.E. J. Neurochem. (2005) [Pubmed]
  3. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Yuan, W., Matthews, R.T., Sandy, J.D., Gottschall, P.E. Neuroscience (2002) [Pubmed]
  4. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., Buttle, D.J., Woodroofe, M.N. Brain Res. (2006) [Pubmed]
  5. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo. MacLean, J.J., Lee, C.R., Grad, S., Ito, K., Alini, M., Iatridis, J.C. Spine. (2003) [Pubmed]
  6. Expression of Versican and ADAMTS During Rat Tooth Eruption. Sone, S., Nakamura, M., Maruya, Y., Takahashi, I., Mizoguchi, I., Mayanagi, H., Sasano, Y. Journal of molecular histology. (2005) [Pubmed]
  7. ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes. Satoh, K., Suzuki, N., Yokota, H. Neurosci. Lett. (2000) [Pubmed]
  8. 3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase. Noe, M.C., Snow, S.L., Wolf-Gouveia, L.A., Mitchell, P.G., Lopresti-Morrow, L., Reeves, L.M., Yocum, S.A., Liras, J.L., Vaughn, M. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
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