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Gene Review

Mmp13  -  matrix metallopeptidase 13

Rattus norvegicus

Synonyms: Collagenase 3, MMP-13, Matrix metalloproteinase-13, UMRCASE
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Disease relevance of Mmp13


High impact information on Mmp13


Chemical compound and disease context of Mmp13

  • Our results suggest that MMP-13 plays an important role in estrogen deficiency-induced bone loss, while estrogen can inhibit bone resorption and reduce bone turnover rate by down-regulating the expression of MMP-13 in osteoblastic cells [9].
  • CONCLUSION: MMP-13 participates in the degradation of newly-formed matrix in the early phase of rat liver fibrosis induced by ethanol, and it was induced in a distinct time frame [10].
  • The aim of this study was to investigate whether matrix metalloproteinases (MMP-13, 9) of Kupffer cells induced by gadolinium chloride (GdCl(3)) treatment can reverse dimethylnitrosamine (DMN)-induced liver fibrosis (in vivo) and the effect of GdCl(3) on MAP kinase activity (in vitro) [11].

Biological context of Mmp13


Anatomical context of Mmp13


Associations of Mmp13 with chemical compounds

  • The phospholipase C (PLC) inhibitors and D609 attenuated serotonin-mediated-IP turnover with a corresponding inhibition of MMP-13 protein production [8].
  • The PKC-specific inhibitors bisindolylmaleimide I, calphostin C, CGP 41251, and the PKCdelta-selective inhibitor rottlerin were able to suppress serotonin up-regulation of MMP-13 [8].
  • Pirfenidone at a dosage of 50 mg x kg(-1) x d(-1) inhibited protein expression of TGF-beta1 and TIMP-1 in lung tissue in the early phase (0.79 and 0.75 times of control group), but had no effect on expression of MMP-13 [16].
  • However, the regulating action of estrogen on the expression of interstitial collagenases MMP-8 and MMP-13 in osteoblastic cells in vivo remains unclear [9].
  • In this study, we investigated the effects of alendronate at concentrations of 1-100 microM on the synthesis of collagenase 3 or matrix metalloproteinase 13 (MMP-13) and tissue inhibitors of MMPs (TIMPs) 1, 2, and 3 in primary Ob-enriched cells from 22-day-old fetal rat calvariae [17].

Regulatory relationships of Mmp13

  • Using primary rat calvarial osteoblastic cells obtained from 21-day old neonatal rats, we determined MMP-13 gene expression when stimulated by parathyroid hormone (PTH), interleukin (IL)-1b, or tumour necrosis factor (TNF)-alpha in the presence or absence of CMT-8 or -5 [18].

Other interactions of Mmp13


Analytical, diagnostic and therapeutic context of Mmp13


  1. Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. Selvamurugan, N., Kwok, S., Alliston, T., Reiss, M., Partridge, N.C. J. Biol. Chem. (2004) [Pubmed]
  2. Rat liver fibrosis regresses better with pegylated interferon alpha2b and ursodeoxycholic acid treatments than spontaneous recovery. Tasci, I., Mas, M.R., Vural, S.A., Comert, B., Alcigir, G., Serdar, M., Mas, N., Isik, A.T., Ates, Y. Liver Int. (2006) [Pubmed]
  3. Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis. Hironaka, K., Sakaida, I., Matsumura, Y., Kaino, S., Miyamoto, K., Okita, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabrò, A., Grappone, C., Pellegrini, G., Evangelista, S., Tramontana, M., Schuppan, D., Herbst, H., Milani, S. Digestion (2004) [Pubmed]
  5. Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons. Nagel, S., Sandy, J.D., Meyding-Lamade, U., Schwark, C., Bartsch, J.W., Wagner, S. Brain Res. (2005) [Pubmed]
  6. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Hayami, T., Pickarski, M., Wesolowski, G.A., McLane, J., Bone, A., Destefano, J., Rodan, G.A., Duong, l.e. .T. Arthritis Rheum. (2004) [Pubmed]
  7. Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells. Schaefer, B., Rivas-Estilla, A.M., Meraz-Cruz, N., Reyes-Romero, M.A., Hernández-Nazara, Z.H., Domínguez-Rosales, J.A., Schuppan, D., Greenwel, P., Rojkind, M. Am. J. Pathol. (2003) [Pubmed]
  8. Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells. Shum, J.K., Melendez, J.A., Jeffrey, J.J. J. Biol. Chem. (2002) [Pubmed]
  9. Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells. Li, J., Liao, E.Y., Dai, R.C., Wei, Q.Y., Luo, X.H. J. Mol. Histol. (2004) [Pubmed]
  10. Expression pattern of matrix metalloproteinases-13 in a rat model of alcoholic liver fibrosis. Yan, S., Chen, G.M., Yu, C.H., Zhu, G.F., Li, Y.M., Zheng, S.S. HBPD INT (2005) [Pubmed]
  11. Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells. Sakaida, I., Hironaka, K., Terai, S., Okita, K. Life Sci. (2003) [Pubmed]
  12. Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways. Onodera, S., Nishihira, J., Iwabuchi, K., Koyama, Y., Yoshida, K., Tanaka, S., Minami, A. J. Biol. Chem. (2002) [Pubmed]
  13. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Solís-Herruzo, J.A., Rippe, R.A., Schrum, L.W., de La Torre, P., García, I., Jeffrey, J.J., Muñoz-Yagüe, T., Brenner, D.A. J. Biol. Chem. (1999) [Pubmed]
  14. Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas. Ye, H.Q., Maeda, M., Yu, F.S., Azar, D.T. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  15. Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia. Nakamura, H., Sato, G., Hirata, A., Yamamoto, T. Bone (2004) [Pubmed]
  16. Low dose pirfenidone suppresses transforming growth factor beta-1 and tissue inhibitor of metalloproteinase-1, and protects rats from lung fibrosis induced by bleomycina. Tian, X.L., Yao, W., Guo, Z.J., Gu, L., Zhu, Y.J. Chin. Med. Sci. J. (2006) [Pubmed]
  17. Alendronate stimulates collagenase 3 expression in osteoblasts by posttranscriptional mechanisms. Varghese, S., Canalis, E. J. Bone Miner. Res. (2000) [Pubmed]
  18. Differential regulation of MMP-13 by chemical modified tetracyclines in osteoblasts. Kirkwood, K., Martin, T., Agnello, K., Kim, Y.J. Journal of the International Academy of Periodontology. (2004) [Pubmed]
  19. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Phillips, P.A., McCarroll, J.A., Park, S., Wu, M.J., Pirola, R., Korsten, M., Wilson, J.S., Apte, M.V. Gut (2003) [Pubmed]
  20. Dynamic biophysical strain modulates proinflammatory gene induction in meniscal fibrochondrocytes. Ferretti, M., Madhavan, S., Deschner, J., Rath-Deschner, B., Wypasek, E., Agarwal, S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  21. Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Kawaguchi, K., Sakaida, I., Tsuchiya, M., Omori, K., Takami, T., Okita, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  22. Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption. Tsubota, M., Sasano, Y., Takahashi, I., Kagayama, M., Shimauchi, H. J. Dent. Res. (2002) [Pubmed]
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