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Gene Review

Bcan  -  brevican

Rattus norvegicus

Synonyms: ALPBRE, BEHAB, Behab, Brain-enriched hyaluronan-binding protein, Brevican core protein
 
 
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Disease relevance of Bcan

  • A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma [1].
  • Further understanding of BEHAB/brevican isoforms will advance our knowledge of the function of this ECM component and may help identify new potential therapeutic targets for primary brain tumors [1].
  • The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2 [2].
  • In order to study a potential role of brevican in the glial reaction after brain injury, its expression was analysed following entorhinal cortex lesion in rats (12 h, 1, 2, 4, 10, 14 and 28 days and 6 months post lesion) [3].
  • They suggest a role of brevican in reactive gliosis and are compatible with the hypothesis that brevican is involved in the synaptic reorganization of denervated brain areas [3].
 

High impact information on Bcan

 

Biological context of Bcan

  • Thus, TGFbeta may play a role in neuronal plasticity through its regulation of brevican and the activity of the ADAMTSs [7].
  • Since brevican, brevican G1 fragment, and NG2 loss occur around the time of progressive cell death and the appearance of the infarct, it may be that H-I rapidly induces a cellular response that actively depletes these proteoglycans from the hippocampal matrix [2].
  • We have determined the complete primary structure of rat brevican and the N-terminal amino acid sequence of the 80-kDa fragment [8].
  • These cell surface brevican binding sites recognize the C-terminal portion of the core protein and are independent of cell surface hyaluronan [6].
  • The authentic, full-length brevican also promotes neuronal cell adhesion and neurite outgrowth [9].
 

Anatomical context of Bcan

 

Associations of Bcan with chemical compounds

 

Physical interactions of Bcan

 

Co-localisations of Bcan

  • In almost all of these sites, brevican immunoreactivity colocalized with that of tenascin-R, which was also substantially codistributed with versican, another member of the lectican family [12].
 

Regulatory relationships of Bcan

  • The observed ADAMTS-induced cleavage of brevican in the dentate outer molecular layer is closely associated with diminished synaptic density, and may, therefore, contribute to synaptic loss and/or reorganization in this region [10].
 

Other interactions of Bcan

  • Most of the CSPGs were extracted to some degree with all the buffers, with neurocan, brevican, aggrecan, and versican particularly associated with the stable urea-extractable PNNs [13].
  • Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain [12].
  • Peak levels of 245/130 kD neurocan, NG2, and 250/200 kD tenascin-C were reached at 8 days, with maximum levels of phosphacan and 140/80 kD brevican attained later, at 1 month post injury [14].
  • In rats that seized after kainate, there was a dramatic elevation in ADAMTS1 and ADAMTS4 transcript that correlated and co-localized with a robust elevation in an extractable, 55-kDa fragment of brevican in temporal lobe and hippocampus [10].
  • These data suggest that TIMP-3 and brevican may act in concert to guide neuronal migration along the RMS [15].
 

Analytical, diagnostic and therapeutic context of Bcan

References

  1. A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. Viapiano, M.S., Matthews, R.T., Hockfield, S. J. Biol. Chem. (2003) [Pubmed]
  2. The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2. Aya-ay, J., Mayer, J., Eakin, A.K., Muffly, B.G., Anello, M., Sandy, J.D., Gottschall, P.E. Exp. Neurol. (2005) [Pubmed]
  3. The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Thon, N., Haas, C.A., Rauch, U., Merten, T., Fässler, R., Frotscher, M., Deller, T. Eur. J. Neurosci. (2000) [Pubmed]
  4. BEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan-binding proteins that is restricted to the brain. Jaworski, D.M., Kelly, G.M., Hockfield, S. J. Cell Biol. (1994) [Pubmed]
  5. Brain enriched hyaluronan binding (BEHAB)/brevican increases aggressiveness of CNS-1 gliomas in Lewis rats. Nutt, C.L., Zerillo, C.A., Kelly, G.M., Hockfield, S. Cancer Res. (2001) [Pubmed]
  6. The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons. Yamada, H., Fredette, B., Shitara, K., Hagihara, K., Miura, R., Ranscht, B., Stallcup, W.B., Yamaguchi, Y. J. Neurosci. (1997) [Pubmed]
  7. Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes. Hamel, M.G., Mayer, J., Gottschall, P.E. J. Neurochem. (2005) [Pubmed]
  8. cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican. Yamada, H., Watanabe, K., Shimonaka, M., Yamasaki, M., Yamaguchi, Y. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  9. Carbohydrate-protein interactions between HNK-1-reactive sulfoglucuronyl glycolipids and the proteoglycan lectin domain mediate neuronal cell adhesion and neurite outgrowth. Miura, R., Ethell, I.M., Yamaguchi, Y. J. Neurochem. (2001) [Pubmed]
  10. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Yuan, W., Matthews, R.T., Sandy, J.D., Gottschall, P.E. Neuroscience (2002) [Pubmed]
  11. Brevican isoforms associate with neural membranes. Seidenbecher, C.I., Smalla, K.H., Fischer, N., Gundelfinger, E.D., Kreutz, M.R. J. Neurochem. (2002) [Pubmed]
  12. Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain. Hagihara, K., Miura, R., Kosaki, R., Berglund, E., Ranscht, B., Yamaguchi, Y. J. Comp. Neurol. (1999) [Pubmed]
  13. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa, S.S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., Fawcett, J.W. J. Biol. Chem. (2006) [Pubmed]
  14. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang, X., Davies, J.E., Davies, S.J. J. Neurosci. Res. (2003) [Pubmed]
  15. Regulation of tissue inhibitor of metalloproteinase-3 (Timp-3) mRNA expression during rat CNS development. Jaworski, D.M., Fager, N. J. Neurosci. Res. (2000) [Pubmed]
 
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