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Ppp1r14a  -  protein phosphatase 1, regulatory...

Mus musculus

Synonyms: 1110001M11Rik, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI-17, Cpi17, Protein kinase C-potentiated inhibitor protein of 17 kDa, ...
 
 
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High impact information on Ppp1r14a

 

Biological context of Ppp1r14a

  • We propose that CPI-17 binds at the PP1 active site where it is dephosphorylated, but association of MYPT1 with PP1C allosterically retards this hydrolysis, resulting in formation of a complex of MYPT1.PP1C.P-CPI-17, leading to an increase in smooth muscle contraction [2].
  • FISH analysis located the human CPI-17 gene on chromosome 19q13.1 [3].
  • The cloned human CPI-17 gene indicated 4 coding exons and CPI-17beta was an alternative splice variant due to deletion of the second exon [3].
  • MYPT-1-PP1delta and its substrate merlin are part of a previously undescribed tumour suppressor cascade that can be hindered in two ways, by mutation of the NF2 gene and by upregulation of the oncoprotein CPI-17 [4].
  • In addition we show that CPI-17 levels are raised in several human tumour cell lines and that the downregulation of CPI-17 induces merlin dephosphorylation, inhibits Ras activation and abolishes the transformed phenotype [4].
 

Anatomical context of Ppp1r14a

 

Associations of Ppp1r14a with chemical compounds

 

Analytical, diagnostic and therapeutic context of Ppp1r14a

  • RhoA, ROCK, and CPI-17 protein expression and activity were determined by immunoblotting for total or phosphorylated proteins [5].

References

  1. Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Eto, M., Bock, R., Brautigan, D.L., Linden, D.J. Neuron (2002) [Pubmed]
  2. Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Eto, M., Kitazawa, T., Brautigan, D.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase. Yamawaki, K., Ito, M., Machida, H., Moriki, N., Okamoto, R., Isaka, N., Shimpo, H., Kohda, A., Okumura, K., Hartshorne, D.J., Nakano, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Jin, H., Sperka, T., Herrlich, P., Morrison, H. Nature (2006) [Pubmed]
  5. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Xie, Z., Su, W., Guo, Z., Pang, H., Post, S.R., Gong, M.C. Cardiovasc. Res. (2006) [Pubmed]
  6. Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle. Bonnevier, J., Arner, A. J. Biol. Chem. (2004) [Pubmed]
 
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