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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Long-Term Depression (Physiology)

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High impact information on Long-Term Depression (Physiology)


Biological context of Long-Term Depression (Physiology)


Anatomical context of Long-Term Depression (Physiology)


Associations of Long-Term Depression (Physiology) with chemical compounds


Gene context of Long-Term Depression (Physiology)

  • LY341495 also blocked NMDA receptor-independent depotentiation and setting of a molecular switch involved in the induction of LTP; effects which have previously been shown to be blocked by the mGlu receptor antagonist (S)-MCPG [17].
  • Surprisingly another form of LTD, depotentiation, requires activation of NR2A-containing NMDARs [18].
  • We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both homosynaptic LTD and depotentiation and that a specific neuronal isoform of type I regulatory subunit (RI beta) is essential [19].
  • In addition, Mas-/- mice show alterations in the onset of depotentiation [20].
  • Here we show that although induction of LTP is unaffected by either pharmacological activation or inhibition of 5-HT4, application of the 5-HT4 receptor agonist, RS67333, completely blocks learning-induced depotentiation of LTP in the hippocampal CA1 region of freely moving rats, suggesting a role for 5-HT4 receptors in behavioural metaplasticity [21].

Analytical, diagnostic and therapeutic context of Long-Term Depression (Physiology)


  1. Rapid exchange of histone H1.1 on chromatin in living human cells. Lever, M.A., Th'ng, J.P., Sun, X., Hendzel, M.J. Nature (2000) [Pubmed]
  2. Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Picconi, B., Centonze, D., Håkansson, K., Bernardi, G., Greengard, P., Fisone, G., Cenci, M.A., Calabresi, P. Nat. Neurosci. (2003) [Pubmed]
  3. Internalization of ionotropic glutamate receptors in response to mGluR activation. Snyder, E.M., Philpot, B.D., Huber, K.M., Dong, X., Fallon, J.R., Bear, M.F. Nat. Neurosci. (2001) [Pubmed]
  4. Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Eto, M., Bock, R., Brautigan, D.L., Linden, D.J. Neuron (2002) [Pubmed]
  5. Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Kameyama, K., Lee, H.K., Bear, M.F., Huganir, R.L. Neuron (1998) [Pubmed]
  6. Regulation of depotentiation and long-term potentiation in the dentate gyrus of freely moving rats by dopamine D2-like receptors. Manahan-Vaughan, D., Kulla, A. Cereb. Cortex (2003) [Pubmed]
  7. Endogenous adenosine attenuates long-term depression and depotentiation in the CA1 region of the rat hippocampus. de Mendonça, A., Almeida, T., Bashir, Z.I., Ribeiro, J.A. Neuropharmacology (1997) [Pubmed]
  8. N-methyl-D-aspartate receptor-independent long-term depression and depotentiation in the sensorimotor cortex of the freely moving rat. Froc, D.J., Racine, R.J. Neuroscience (2004) [Pubmed]
  9. A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Zhuo, M., Zhang, W., Son, H., Mansuy, I., Sobel, R.A., Seidman, J., Kandel, E.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex. Huber, K.M., Sawtell, N.B., Bear, M.F. J. Neurosci. (1998) [Pubmed]
  11. Depotentiation in the dentate gyrus of freely moving rats is modulated by D1/D5 dopamine receptors. Kulla, A., Manahan-Vaughan, D. Cereb. Cortex (2000) [Pubmed]
  12. Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats. Lin, C.H., Lee, C.C., Huang, Y.C., Wang, S.J., Gean, P.W. Learn. Mem. (2005) [Pubmed]
  13. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Lee, H.K., Kameyama, K., Huganir, R.L., Bear, M.F. Neuron (1998) [Pubmed]
  14. Lithium treatment blocks long-term synaptic depression in the striatum. Calabresi, P., Pisani, A., Mercuri, N.B., Bernardi, G. Neuron (1993) [Pubmed]
  15. Developmental dissociation of serotonin-induced spike broadening and synaptic facilitation in Aplysia sensory neurons. Stark, L.L., Carew, T.J. J. Neurosci. (1999) [Pubmed]
  16. Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. Huang, C.C., Liang, Y.C., Hsu, K.S. J. Biol. Chem. (2001) [Pubmed]
  17. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Fitzjohn, S.M., Bortolotto, Z.A., Palmer, M.J., Doherty, A.J., Ornstein, P.L., Schoepp, D.D., Kingston, A.E., Lodge, D., Collingridge, G.L. Neuropharmacology (1998) [Pubmed]
  18. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. Massey, P.V., Johnson, B.E., Moult, P.R., Auberson, Y.P., Brown, M.W., Molnar, E., Collingridge, G.L., Bashir, Z.I. J. Neurosci. (2004) [Pubmed]
  19. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Brandon, E.P., Zhuo, M., Huang, Y.Y., Qi, M., Gerhold, K.A., Burton, K.A., Kandel, E.R., McKnight, G.S., Idzerda, R.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. Walther, T., Balschun, D., Voigt, J.P., Fink, H., Zuschratter, W., Birchmeier, C., Ganten, D., Bader, M. J. Biol. Chem. (1998) [Pubmed]
  21. The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo. Kemp, A., Manahan-Vaughan, D. Cereb. Cortex (2005) [Pubmed]
  22. Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro. O'Mara, S.M., Rowan, M.J., Anwyl, R. Neuropharmacology (1995) [Pubmed]
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