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Gene Review

PPP1R14A  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: 17 kDa PKC-potentiated inhibitory protein of PP1, CPI-17, CPI17, PPP1INL, Protein kinase C-potentiated inhibitor protein of 17 kDa, ...


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Disease relevance of PPP1R14A

  • Analysis of the expression and phosphorylation of Ca(2+)-sensitizing proteins (MYPT1 and CPI-17) in vessels from rats and patients with cirrhosis suggested decreased Ca2+ sensitivity [1].
  • PPP1R14A gene copy number variants (CNV) and gene expression are both decreased in colorectal carcinoma samples  [2] [3]

High impact information on PPP1R14A


Biological context of PPP1R14A


Anatomical context of PPP1R14A


Associations of PPP1R14A with chemical compounds

  • Together these data suggest the potential importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise [8].
  • CPI-17 interacted with the cysteine-rich domain of PKC and was phosphorylated by all PKC isotypes [10].
  • Phosphorylated CPI-17 at threonine-38 residue (p(Thr38)-CPI-17), MYPT1 at threonine-696 residue (p(Thr696)-MYPT1), and MLC(20) at threonine-18/serine-19 residues (p(Thr18/Ser19)-MLC(20)) were also determined in the basal state and after pretreatment with the ROK inhibitor Y 27632 [6].
  • Thus, CPI-17 as a substrate of Rho-kinase could be involved in the Ca(2+) sensitization of smooth muscle contraction as a downstream effector of Rho-kinase [11].
  • Forskolin, dbcAMP, and isoproterenol inhibited KCl-induced Rho activation and phosphorylation of MYPT1 and CPI-17 [12].

Regulatory relationships of PPP1R14A


Other interactions of PPP1R14A


Analytical, diagnostic and therapeutic context of PPP1R14A


  1. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg, M., Trebicka, J., Biecker, E., Schepke, M., Sauerbruch, T., Heller, J. Hepatology (2007) [Pubmed]
  2. Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma. Kurashina, K., Yamashita, Y., Ueno, T., Koinuma, K., Ohashi, J., Horie, H., Miyakura, Y., Hamada, T., Haruta, H., Hatanaka, H., Soda, M., Choi, Y.L., Takada, S., Yasuda, Y., Nagai, H., Mano, H. Cancer. Sci. (2008) [Pubmed]
  3. A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Hong, Y., Downey, T., Eu, K.W., Koh, P.K., Cheah, P.Y. Clin. Exp. Metastasis. (2010) [Pubmed]
  4. Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Eto, M., Kitazawa, T., Brautigan, D.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Histamine-induced phosphorylation of the regulatory light chain of myosin II disrupts the barrier integrity of corneal endothelial cells. Srinivas, S.P., Satpathy, M., Guo, Y., Anandan, V. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  6. Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. Patel, C.A., Rattan, S. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  7. Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2. Li, Z., Yu, L., Zhang, Y., Gao, J., Zhang, P., Wan, B., Chen, C., Zhao, S. Mol. Biol. Rep. (2001) [Pubmed]
  8. Role of CPI-17 in the regulation of endothelial cytoskeleton. Kolosova, I.A., Ma, S.F., Adyshev, D.M., Wang, P., Ohba, M., Natarajan, V., Garcia, J.G., Verin, A.D. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  9. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle. Eto, M., Senba, S., Morita, F., Yazawa, M. FEBS Lett. (1997) [Pubmed]
  10. Association of CPI-17 with protein kinase C and casein kinase I. Zemlickova, E., Johannes, F.J., Aitken, A., Dubois, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. Koyama, M., Ito, M., Feng, J., Seko, T., Shiraki, K., Takase, K., Hartshorne, D.J., Nakano, T. FEBS Lett. (2000) [Pubmed]
  12. Ca2+-Independent, Inhibitory Effects of Cyclic Adenosine 5'-Monophosphate on Ca2+ Regulation of Phosphoinositide 3-Kinase C2{alpha}, Rho, and Myosin Phosphatase in Vascular Smooth Muscle. Azam, M.A., Yoshioka, K., Ohkura, S., Takuwa, N., Sugimoto, N., Sato, K., Takuwa, Y. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  13. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. Huang, J., Mahavadi, S., Sriwai, W., Hu, W., Murthy, K.S. Biochem. J. (2006) [Pubmed]
  14. Augmentation of endothelin-1-induced phosphorylation of CPI-17 and myosin light chain in bronchial smooth muscle from airway hyperresponsive rats. Sakai, H., Chiba, Y., Misawa, M. Biol. Pharm. Bull. (2006) [Pubmed]
  15. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. MacDonald, J.A., Eto, M., Borman, M.A., Brautigan, D.L., Haystead, T.A. FEBS Lett. (2001) [Pubmed]
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