Gene Review:
CAPN1 - calpain 1, (mu/I) large subunit
Homo sapiens
Synonyms:
CANP, CANP 1, CANP1, CANPL1, Calcium-activated neutral proteinase 1, ...
- Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin. Reichrath, J., Welter, C., Mitschele, T., Classen, U., Meineke, V., Tilgen, W., Seifert, M. J. Pathol. (2003)
- A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13. Bergman, L., Silins, G., Grimmond, S., Hummerich, H., Stewart, C., Little, P., Hayward, N. Genomics (1999)
- Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit. Vilei, E.M., Calderara, S., Anagli, J., Berardi, S., Hitomi, K., Maki, M., Carafoli, E. J. Biol. Chem. (1997)
- Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms. Vitto, A., Nixon, R.A. J. Neurochem. (1986)
- Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP). Inomata, M., Hayashi, M., Nakamura, M., Imahori, K., Kawashima, S. J. Biochem. (1985)
- Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Nixon, R.A., Saito, K.I., Grynspan, F., Griffin, W.R., Katayama, S., Honda, T., Mohan, P.S., Shea, T.B., Beermann, M. Ann. N. Y. Acad. Sci. (1994)
- Molecular cloning and characterization of a human DNA binding factor that represses transcription. Kageyama, R., Pastan, I. Cell (1989)
- Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle. Yanagida, T., Arata, T., Oosawa, F. Nature (1985)
- On the association of glycoprotein Ib and actin-binding protein in human platelets. Okita, J.R., Pidard, D., Newman, P.J., Montgomery, R.R., Kunicki, T.J. J. Cell Biol. (1985)
- A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Shields, D.C., Schaecher, K.E., Saido, T.C., Banik, N.L. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Saito, K., Elce, J.S., Hamos, J.E., Nixon, R.A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Tryptophan protects human melanoma cells against gamma-interferon and tumour necrosis factor-alpha: a unifying mechanism of action. Wood, J.M., Ehrke, C., Schallreuter, K.U. Melanoma Res. (1991)
- Ca overload and the action of calcium sensitive proteases, phospholipases and prostaglandin E2 in myocardial cell degradation. Toyo-oka, T., Hara, K., Nakamura, N., Kitahara, M., Masaki, T. Basic Res. Cardiol. (1985)
- Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. Matena, K., Boehm, T., Dear, N. Genomics (1998)
- Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle. Sorimachi, H., Imajoh-Ohmi, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y., Suzuki, K. J. Biol. Chem. (1989)
- Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni. Andresen, K., Tom, T.D., Strand, M. J. Biol. Chem. (1991)
- Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP. Banik, N.L., DeVries, G.H., Neuberger, T., Russell, T., Chakrabarti, A.K., Hogan, E.L. J. Neurosci. Res. (1991)
- Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. Takeuchi, K.H., Saito, K.I., Nixon, R.A. J. Neurochem. (1992)
- Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP. Saito, K., Nixon, R.A. Neurochem. Res. (1993)
- Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells. Shea, T.B., Beermann, M.L., Nixon, R.A. J. Neurochem. (1991)
- Purification and characterization of Ca2+-activated neutral protease inhibitor from human platelets. Shiba, E., Tsujinaka, T., Kambayashi, J., Kosaki, G. Thromb. Res. (1983)
- Ca(2+)-activated neutral protease is active in the erythrocyte membrane in its nonautolyzed 80-kDa form. Molinari, M., Anagli, J., Carafoli, E. J. Biol. Chem. (1994)
- Phospholipids inhibit proteolysis of protein kinase C alpha by mM calcium-requiring calpain. Lang, D., Beermann, M.L., Hauser, G., Cressman, C.M., Shea, T.B. Neurochem. Res. (1995)
- Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene. Pang, J.T., Lloyd, S.E., Wooding, C., Farren, B., Pottinger, B., Harding, B., Leigh, S.E., Pook, M.A., Benham, F.J., Gillett, G.T., Taggart, R.T., Thakker, R.V. Hum. Genet. (1996)
- A low-calcium-requiring calcium-activated neutral proteinase from human placenta. Shastri, R., Anandaraj, M.P. Biochim. Biophys. Acta (1986)
- The selective anticancer activity of the endogenous inhibitor of calcium-activated neutral proteinase. A histological, cytological and chemosensitivity study. Logothetou-Rella, H. Histol. Histopathol. (1994)