The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ZNF35  -  zinc finger protein 35

Homo sapiens

Synonyms: HF.10, HF10, Zfp105, Zinc finger protein 35, Zinc finger protein HF.10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ZNF35


High impact information on ZNF35

  • The region surrounding the ZNF35 zinc finger protein gene on 3p21 is of particular interest, as this region of chromosome 3 is frequently involved in rearrangements and/or deletions associated with various human tumors including lung and renal carcinoma [5].
  • We have analyzed yeast artificial chromosomes (YACs), identified by PCR screening, using oligonucleotides derived from the ZNF35 gene [5].
  • CONCLUSIONS: This pilot study found HF10 to be safe and effective against metastatic breast cancer [4].
  • A comparison between pimonidazole binding expressed as the fraction of fields at the highest score and HF10 showed a trend for the most well-oxygenated tumors having a low fraction of fields; however, the correlation did not reach statistical significance (p = 0.43, r = 0.165; Spearman's rank correlation test) [6].
  • The ZNF35 human zinc finger gene encodes a sequence-specific DNA-binding protein [1].

Biological context of ZNF35


Anatomical context of ZNF35

  • Using transient CAT assay in cotransfection experiments in cultured cells, we have determined that the HF.10 finger protein is a transcriptional transactivator [7].
  • One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines [2].
  • This study shows that the ZFHO penetration ability of human spermatozoa with poor motility can be improved by using HTF medium as compared with the use of HF-10 medium [8].
  • Forty semen specimens were each divided into two aliquots; one aliquot was washed with and incubated in HF-10 medium and the other in HTF medium [8].
  • A large number of inflammatory cells infiltrated into the bladder mucosa at 3 days after HF10 treatment in the preimmunized mice [9].

Associations of ZNF35 with chemical compounds


Other interactions of ZNF35

  • The genomic region surrounding HF.10 exon 1 contains a CpG island and acts as a promoter in vitro [7].
  • The penetration ability of human spermatozoa on zona-free hamster ovum when using Ham's F-10 (HF-10) medium was compared with that when using a medium based on the composition of human tubal fluid [8].

Analytical, diagnostic and therapeutic context of ZNF35


  1. The ZNF35 human zinc finger gene encodes a sequence-specific DNA-binding protein. Pengue, G., Cannada-Bartoli, P., Lania, L. FEBS Lett. (1993) [Pubmed]
  2. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. Donti, E., Lanfrancone, L., Huebner, K., Pascucci, A., Venti, G., Pengue, G., Grignani, F., Croce, C.M., Lania, L., Pelicci, P.G. Hum. Genet. (1990) [Pubmed]
  3. Intratumoral injection of herpes simplex virus HF10 in recurrent breast cancer. Nakao, A., Kimata, H., Imai, T., Kikumori, T., Teshigahara, O., Nagasaka, T., Goshima, F., Nishiyama, Y. Ann. Oncol. (2004) [Pubmed]
  4. Pilot Study of Oncolytic Viral Therapy Using Mutant Herpes Simplex Virus (HF10) Against Recurrent Metastatic Breast Cancer. Kimata, H., Imai, T., Kikumori, T., Teshigahara, O., Nagasaka, T., Goshima, F., Nishiyama, Y., Nakao, A. Ann. Surg. Oncol. (2006) [Pubmed]
  5. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Pengue, G., Calabrò, V., Cannada-Bartoli, P., De Luca, P., Esposito, T., Taillon-Miller, P., LaForgia, S., Druck, T., Huebner, K., D'Urso, M. Hum. Mol. Genet. (1993) [Pubmed]
  6. Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma. Nordsmark, M., Loncaster, J., Chou, S.C., Havsteen, H., Lindegaard, J.C., Davidson, S.E., Varia, M., West, C., Hunter, R., Overgaard, J., Raleigh, J.A. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  7. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. Lanfrancone, L., Pengue, G., Pandolfi, P.P., Salcini, A.E., Giacomucci, A., Longo, L., Donti, E., De Luca, P., La Mantia, G., Pelicci, P.G. Genomics (1992) [Pubmed]
  8. Comparison of the effects on penetration capacity of human spermatozoa between using Ham's F-10 medium and a medium based on the composition of human tubal fluid. Cai, X.Q., Marik, J.J. Andrologia (1990) [Pubmed]
  9. Herpes simplex virus type 1 mutant HF10 oncolytic viral therapy for bladder cancer. Kohno, S., Luo, C., Goshima, F., Nishiyama, Y., Sata, T., Ono, Y. Urology (2005) [Pubmed]
  10. Ham's F-10 medium and Ham's F-10 medium plus vitamin E have protective effect against oxidative stress in human semen. Yenilmez, E., Yildirmis, S., Yulug, E., Aydin, S., Tekelioglu, Y., Erdem, E., Topbas, M., Arvas, H. Urology (2006) [Pubmed]
  11. Oncolytic viral therapy for breast cancer with herpes simplex virus type 1 mutant HF 10. Teshigahara, O., Goshima, F., Takao, K., Kohno, S., Kimata, H., Nakao, A., Nishiyama, Y. Journal of surgical oncology. (2004) [Pubmed]
WikiGenes - Universities