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Chemical Compound Review

Pimonidazol     1-(2-nitroimidazol-1-yl)-3- (1...

Synonyms: PIMONIDAZOLE, Pimonidazolum, CHEMBL58752, SureCN51977, NSC-380540, ...
 
 
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Disease relevance of NSC318502

 

High impact information on NSC318502

 

Chemical compound and disease context of NSC318502

 

Biological context of NSC318502

  • These cells stained positively for pimonidazole and therefore generated hypoxic stress within the target tissue, a prerequisite for the differentiation of stem cells to chondrocytes and subsequent heterotopic bone formation [13].
  • METHODS: Using punch biopsy wounds in rats as a wound healing model, the distributions of vascular endothelial growth factor, transforming growth factor-beta, tumor necrosis factor-alpha, and pimonidazole adducts (as a hypoxia marker) were followed immunohistochemically during the healing process [14].
  • Recent studies show that carbonic anhydrase 9 (CA9) is up-regulated by hypoxia and that its immunohistochemical tissue distribution follows the distribution of the radiosensitizer pimonidazole (C. C. Wykoff et al., Cancer Res. 60: 7075-7083, 2001) [15].
  • CONCLUSIONS: Colocalization of immunostaining for involucrin and pimonidazole binding is consistent with oxygen regulation, but the lack of involucrin expression in hypoxic regions of poorly differentiated tumors indicates that its transcriptional status with respect to hypoxia induction is altered by cell differentiation [11].
  • Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination [16].
 

Anatomical context of NSC318502

 

Associations of NSC318502 with other chemical compounds

 

Gene context of NSC318502

 

Analytical, diagnostic and therapeutic context of NSC318502

References

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