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Gene Review

Arf6  -  ADP-ribosylation factor 6

Rattus norvegicus

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High impact information on Arf6

  • Arf6 activation releases docked beta-arrestin necessary for receptor desensitization, providing a feedback mechanism for receptor self-regulation [1].
  • We conclude that both activation of ARF6 by antigen and a continual PLD2 activity are essential for local phosphatidylinositol(4,5)bisphosphate generation that regulates dynamic actin cytoskeletal rearrangements [2].
  • Quantitative Western blotting showed that expression of endogenous Arf1 was 26-180 times higher than Arf6 [3].
  • As a first step in understanding the role of Arfs in renal physiology, immunocytochemistry and Western blotting were performed to characterize the expression and targeting of Arf1 and Arf6 in epithelial cells in situ [3].
  • In contrast, Arf6 was associated exclusively with basolateral membranes and vesicles in the CD [3].

Biological context of Arf6

  • Arf6 regulates a clathrin-independent endocytic membrane recycling pathway in nonpolarized cells and clathrin-dependent endocytosis in polarized cells [4].
  • In addition to an essential role of Arf1 in vesicle budding, recent observations suggest a role for Arf6 in calcium-dependent exocytosis in bovine adrenal chromaffin cells [5].

Anatomical context of Arf6


Associations of Arf6 with chemical compounds

  • Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation [7].

Other interactions of Arf6


  1. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Mukherjee, S., Gurevich, V.V., Jones, J.C., Casanova, J.E., Frank, S.R., Maizels, E.T., Bader, M.F., Kahn, R.A., Palczewski, K., Aktories, K., Hunzicker-Dunn, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells. O'Luanaigh, N., Pardo, R., Fensome, A., Allen-Baume, V., Jones, D., Holt, M.R., Cockcroft, S. Mol. Biol. Cell (2002) [Pubmed]
  3. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. El-Annan, J., Brown, D., Breton, S., Bourgoin, S., Ausiello, D.A., Marshansky, V. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  4. ADP-ribosylation factor 6 regulation of phosphatidylinositol-4,5-bisphosphate synthesis, endocytosis, and exocytosis. Aikawa, Y., Martin, T.F. Meth. Enzymol. (2005) [Pubmed]
  5. ADP-ribosylation factors in rat parotid acinar cells. Dohke, Y., Hara-Yokoyama, M., Fujita-Yoshigaki, J., Furuyama, S., Sugiya, H. European journal of morphology. (1998) [Pubmed]
  6. High glucose-induced membrane translocation of PKC betaI is associated with Arf6 in glomerular mesangial cells. Padival, A.K., Hawkins, K.S., Huang, C. Mol. Cell. Biochem. (2004) [Pubmed]
  7. Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation. Sakagami, H., Matsuya, S., Nishimura, H., Suzuki, R., Kondo, H. Eur. J. Neurosci. (2004) [Pubmed]
  8. Analysis of the interaction between cytohesin 2 and IPCEF1. Venkateswarlu, K. Meth. Enzymol. (2005) [Pubmed]
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