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Gene Review

Arf6  -  ADP-ribosylation factor 6

Mus musculus

Synonyms: AI788669, AW496366
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Disease relevance of Arf6

  • To determine whether ARF6 is involved in insulin-regulated exocytosis, 3T3-L1 adipocytes were infected with recombinant adenovirus expressing wild-type ARF6 or an ARF6 dominant negative mutant (D125N) that encodes a protein with nucleotide specificity modified from guanine to xanthine [1].

High impact information on Arf6

  • PIP2 formation is regulated by Arf6 [2].
  • This reduction in PIP2 occurred in spite of fact that PIP5K appeared to be recruited efficiently to the site of bacterial binding, indicating a role for Arf6 in activation of the kinase [2].
  • V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway [3].
  • A dominant-negative mutant of ARF6 (T27N mutation) dramatically affected FcR-mediated phagocytosis [4].
  • Here, we report that endogenous ADP ribosylation factor 6 (ARF6), a small GTP-binding protein, undergoes a sharp and transient activation in macrophages when phagocytosis was initiated via receptors for the Fc portion of immunoglobulins (FcRs) [4].

Biological context of Arf6

  • Livers from ARF6-/- embryos are smaller and exhibit hypocellularity, due to the onset of midgestational liver cell apoptosis [5].
  • The mammalian small GTPase ADP-ribosylation factor 6 (ARF6) plays important roles in a wide variety of cellular events, including endocytosis, actin cytoskeletal reorganization, and phosphoinositide metabolism [5].

Anatomical context of Arf6


Associations of Arf6 with chemical compounds


Other interactions of Arf6

  • We also demonstrate that Arf6 also plays a role in the secretion of ACRP30 [7].
  • Here we investigated whether the small GTPase, ADP-ribosylation factor 6 (ARF6), which regulates actin dynamics and peripheral vesicular trafficking, is involved in the regulation of spine formation [11].

Analytical, diagnostic and therapeutic context of Arf6


  1. ADP-ribosylation factor 6 (ARF6) defines two insulin-regulated secretory pathways in adipocytes. Yang, C.Z., Mueckler, M. J. Biol. Chem. (1999) [Pubmed]
  2. Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. Wong, K.W., Isberg, R.R. J. Exp. Med. (2003) [Pubmed]
  3. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Hurtado-Lorenzo, A., Skinner, M., El Annan, J., Futai, M., Sun-Wada, G.H., Bourgoin, S., Casanova, J., Wildeman, A., Bechoua, S., Ausiello, D.A., Brown, D., Marshansky, V. Nat. Cell Biol. (2006) [Pubmed]
  4. ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. Niedergang, F., Colucci-Guyon, E., Dubois, T., Raposo, G., Chavrier, P. J. Cell Biol. (2003) [Pubmed]
  5. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Suzuki, T., Kanai, Y., Hara, T., Sasaki, J., Sasaki, T., Kohara, M., Maehama, T., Taya, C., Shitara, H., Yonekawa, H., Frohman, M.A., Yokozeki, T., Kanaho, Y. Mol. Cell. Biol. (2006) [Pubmed]
  6. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Martinu, L., Masuda-Robens, J.M., Robertson, S.E., Santy, L.C., Casanova, J.E., Chou, M.M. Mol. Cell. Biol. (2004) [Pubmed]
  7. ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Clarke, M., Ewart, M.A., Santy, L.C., Prekeris, R., Gould, G.W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  8. ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate. Lawrence, J.T., Birnbaum, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. Jackson, T.R., Brown, F.D., Nie, Z., Miura, K., Foroni, L., Sun, J., Hsu, V.W., Donaldson, J.G., Randazzo, P.A. J. Cell Biol. (2000) [Pubmed]
  10. ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes. Lawrence, J.T., Birnbaum, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  11. The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. Miyazaki, H., Yamazaki, M., Watanabe, H., Maehama, T., Yokozeki, T., Kanaho, Y. FEBS Lett. (2005) [Pubmed]
  12. Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. Matsuya, S., Sakagami, H., Tohgo, A., Owada, Y., Shin, H.W., Takeshima, H., Nakayama, K., Kokubun, S., Kondo, H. J. Neurochem. (2005) [Pubmed]
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