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Gene Review

AT4G20380  -  zinc finger protein LSD1

Arabidopsis thaliana

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Disease relevance of LSD1


High impact information on LSD1


Biological context of LSD1

  • Thus, LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway [2].
  • The predicted LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC [2].
  • We propose that the roles of LSD1 in light acclimation and in restricting pathogen-induced cell death are functionally linked [5].
  • These vectors were used to investigate and visualize homodimerization of the basic leucine zipper (bZIP) transcription factor bZIP63 and the zinc finger protein lesion simulating disease 1 (LSD1) from Arabidopsis as well as the dimer formation of the tobacco 14-3-3 protein T14-3c [6].
  • LSD1 likely functions as a cellular hub, where its interaction with AtbZIP10 and additional, as yet unidentified, proteins contributes significantly to plant oxidative stress responses [3].

Associations of LSD1 with chemical compounds

  • Salicylic acid, which induces stomatal closure, inhibits catalase activity and triggers the rcd phenotype in lsd1, also impaired acclimation of wild-type plants to conditions that promote EEE [5].
  • This lsd1 mutant also had reduced stomatal conductance and catalase activity in short-day permissive conditions and induced H(2)O(2) accumulation followed by rcd when stomatal gas exchange was further impeded [5].
  • Taken together, conditional PR-1 accumulation in lsd1 is regulated not by the redox state but by the endogenous level of glutathione [7].

Regulatory relationships of LSD1


Other interactions of LSD1


  1. LSD1 regulates salicylic acid induction of copper zinc superoxide dismutase in Arabidopsis thaliana. Kliebenstein, D.J., Dietrich, R.A., Martin, A.C., Last, R.L., Dangl, J.L. Mol. Plant Microbe Interact. (1999) [Pubmed]
  2. A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death. Dietrich, R.A., Richberg, M.H., Schmidt, R., Dean, C., Dangl, J.L. Cell (1997) [Pubmed]
  3. bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. Kaminaka, H., Näke, C., Epple, P., Dittgen, J., Schütze, K., Chaban, C., Holt, B.F., Merkle, T., Schäfer, E., Harter, K., Dangl, J.L. EMBO J. (2006) [Pubmed]
  4. The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathway controlled by LSD1 in Arabidopsis. Rustérucci, C., Aviv, D.H., Holt, B.F., Dangl, J.L., Parker, J.E. Plant Cell (2001) [Pubmed]
  5. LESION SIMULATING DISEASE 1 is required for acclimation to conditions that promote excess excitation energy. Mateo, A., Mühlenbock, P., Rustérucci, C., Chang, C.C., Miszalski, Z., Karpinska, B., Parker, J.E., Mullineaux, P.M., Karpinski, S. Plant Physiol. (2004) [Pubmed]
  6. Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation. Walter, M., Chaban, C., Schütze, K., Batistic, O., Weckermann, K., Näke, C., Blazevic, D., Grefen, C., Schumacher, K., Oecking, C., Harter, K., Kudla, J. Plant J. (2004) [Pubmed]
  7. Induction of PR-1 accumulation accompanied by runaway cell death in the lsd1 mutant of Arabidopsis is dependent on glutathione levels but independent of the redox state of glutathione. Senda, K., Ogawa, K. Plant Cell Physiol. (2004) [Pubmed]
  8. A novel myb oncogene homologue in Arabidopsis thaliana related to hypersensitive cell death. Daniel, X., Lacomme, C., Morel, J.B., Roby, D. Plant J. (1999) [Pubmed]
  9. Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins. Epple, P., Mack, A.A., Morris, V.R., Dangl, J.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Molecular analysis of programmed cell death during senescence in Arabidopsis thaliana and Brassica oleracea: cloning broccoli LSD1, Bax inhibitor and serine palmitoyltransferase homologues. Coupe, S.A., Watson, L.M., Ryan, D.J., Pinkney, T.T., Eason, J.R. J. Exp. Bot. (2004) [Pubmed]
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