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Gene Review

CMPK1  -  cytidine monophosphate (UMP-CMP) kinase 1,...

Homo sapiens

Synonyms: CK, CMK, CMPK, Deoxycytidylate kinase, Nucleoside-diphosphate kinase, ...
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Disease relevance of CMPK


High impact information on CMPK


Chemical compound and disease context of CMPK


Biological context of CMPK


Anatomical context of CMPK


Associations of CMPK with chemical compounds

  • Furthermore, UMP/CMPK was able to phosphorylate all of the deoxycytidine analogue monophosphates that we tested [1].
  • Here, we reevaluated the optimal reaction conditions for human recombinant human UMP/CMP kinase to phosphorylate dCMP and CMP (referred as dCMPK and CMPK activities) [15].
  • Human UMP/CMP kinase (cytidylate kinase; EC is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs [15].
  • We have investigated the kinetic parameters for the phosphorylation of 1-beta-D-arabinofuranosylcytosine (araC) and 2', 2'-difluorodeoxycytidine (dFdC) to their diphosphate forms catalyzed by human UMP-CMP kinase [11].
  • We showed that the recombinant UMP-CMP kinase phosphorylated CMP, dCMP, and UMP with highest efficiency and dUMP, AMP, and dAMP with lower efficiency [11].

Other interactions of CMPK


Analytical, diagnostic and therapeutic context of CMPK

  • Detection of IL-6 and its receptor mRNAs in a megakaryocytic cell line, CMK, by an RT-nested PCR [19].


  1. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Liou, J.Y., Dutschman, G.E., Lam, W., Jiang, Z., Cheng, Y.C. Cancer Res. (2002) [Pubmed]
  2. Uridine monophosphate kinase and susceptibility to invasive Haemophilus influenzae type B disease. Petersen, G.M., Silimperi, D.R., Scott, E.M., Hall, D.R., Rotter, J.I., Ward, J.I. Adv. Exp. Med. Biol. (1986) [Pubmed]
  3. Human immunodeficiency virus infection of megakaryocytic cells. Sakaguchi, M., Sato, T., Groopman, J.E. Blood (1991) [Pubmed]
  4. Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. Adachi, M., Ryo, R., Yoshida, A., Sugano, W., Yasunaga, M., Saigo, K., Yamaguchi, N., Sato, T., Sano, K., Kaibuchi, K. Oncogene (1992) [Pubmed]
  5. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia. Sato, T., Fuse, A., Eguchi, M., Hayashi, Y., Ryo, R., Adachi, M., Kishimoto, Y., Teramura, M., Mizoguchi, H., Shima, Y. Br. J. Haematol. (1989) [Pubmed]
  6. Red cell uridine monophosphate kinase: effects of red cell aging on the activity of two UMPK gene products. Teng, Y., Chen, S., Giblett, E.R. Am. J. Hum. Genet. (1976) [Pubmed]
  7. Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells. Melemed, A.S., Ryder, J.W., Vik, T.A. Blood (1997) [Pubmed]
  8. Cytosolic calcium mobilization and thromboxane synthesis in a human megakaryocytic leukemia cell. Ryo, R., Yoshida, A., Adachi, M., Sugano, W., Yasunaga, M., Yoneda, N., Yamaguchi, N., Sato, T. Exp. Hematol. (1990) [Pubmed]
  9. Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products. Snider, G.L., Lucey, E.C., Christensen, T.G., Stone, P.J., Calore, J.D., Catanese, A., Franzblau, C. Am. Rev. Respir. Dis. (1984) [Pubmed]
  10. Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. Frangioni, J.V., Neel, B.G. J. Cell. Sci. (1993) [Pubmed]
  11. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. Van Rompay, A.R., Johansson, M., Karlsson, A. Mol. Pharmacol. (1999) [Pubmed]
  12. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. Pearman, A.T., Castro-Faria-Neto, H.C., McIntyre, T.M., Prescott, S.M., Stafforini, D.M. Life Sci. (2001) [Pubmed]
  13. Red cell uridine monophosphate kinase polymorphism in Japanese. Harada, S., Ito, M., Misawa, S. Humangenetik. (1975) [Pubmed]
  14. Genetic analysis of erythrocyte uridine monophosphate kinase and aminolevulinate dehydrase and its application to paternity testing. Caeiro, J.L., Llano, C., Garcia-Luengo, S., Canabal, O. J. Forensic Sci. (1989) [Pubmed]
  15. Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. Hsu, C.H., Liou, J.Y., Dutschman, G.E., Cheng, Y.C. Mol. Pharmacol. (2005) [Pubmed]
  16. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. Ozaki, K., Kuroki, T., Hayashi, S., Nakamura, Y. Genomics (1996) [Pubmed]
  17. Polymorphism of red cell enzymes in Alaskan ethnic groups. Scott, E.M., Wright, R.C. Ann. Hum. Genet. (1978) [Pubmed]
  18. Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: V. Genetic polymorphism of cytosol 31k polypeptide. Kondo, I., Yamakawa, K., Shibasaki, M., Yamamoto, T., Hamaguchi, H. Hum. Genet. (1984) [Pubmed]
  19. Detection of IL-6 and its receptor mRNAs in a megakaryocytic cell line, CMK, by an RT-nested PCR. Nakayama, K. Ann. Hematol. (1994) [Pubmed]
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