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Gene Review

NRT2:1  -  nitrate transporter 2:1

Arabidopsis thaliana

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Disease relevance of ATNRT2:1

  • Analysis of atnrt2.1 mutants showed that this constitutes a crucial adaptive response against NH(4)(+) toxicity because NO(3)(-) taken up by the HATS in this situation prevents the detrimental effects of pure NH(4)(+) nutrition [1].

High impact information on ATNRT2:1


Biological context of ATNRT2:1


Anatomical context of ATNRT2:1


Associations of ATNRT2:1 with chemical compounds

  • Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues [9].
  • Moreover, growth on glucose induced genes for nitrogen remobilisation that are typically enhanced during developmental senescence, including the glutamine synthetase gene GLN1;4 and the nitrate transporter gene AtNRT2 [10].
  • No rapid changes in NRT2.1 abundance were observed in response to light, sucrose, or nitrogen treatments that strongly affect both NRT2.1 mRNA level and HATS activity [11].

Other interactions of ATNRT2:1

  • Root Nrt2;1At expression levels were strongly correlated with inducible high-affinity 13NO3- influx into intact roots under several treatment conditions [6].
  • One family, consisting of AtACH1 and AtACH2, appears to be peroxisomal, as they have type-1 peroxisomal targeting sequences [12].

Analytical, diagnostic and therapeutic context of ATNRT2:1


  1. Regulation of the High-Affinity NO3- Uptake System by NRT1.1-Mediated NO3- Demand Signaling in Arabidopsis. Krouk, G., Tillard, P., Gojon, A. Plant Physiol. (2006) [Pubmed]
  2. Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation. Liu, K.H., Tsay, Y.F. EMBO J. (2003) [Pubmed]
  3. Transcript profiling in the chl1-5 mutant of Arabidopsis reveals a role of the nitrate transporter NRT1.1 in the regulation of another nitrate transporter, NRT2.1. Muños, S., Cazettes, C., Fizames, C., Gaymard, F., Tillard, P., Lepetit, M., Lejay, L., Gojon, A. Plant Cell (2004) [Pubmed]
  4. The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues. Little, D.Y., Rao, H., Oliva, S., Daniel-Vedele, F., Krapp, A., Malamy, J.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. A central role for the nitrate transporter NRT2.1 in the integrated morphological and physiological responses of the root system to nitrogen limitation in Arabidopsis. Remans, T., Nacry, P., Pervent, M., Girin, T., Tillard, P., Lepetit, M., Gojon, A. Plant Physiol. (2006) [Pubmed]
  6. Regulation of a putative high-affinity nitrate transporter (Nrt2;1At) in roots of Arabidopsis thaliana. Zhuo, D., Okamoto, M., Vidmar, J.J., Glass, A.D. Plant J. (1999) [Pubmed]
  7. An arabidopsis T-DNA mutant affected in Nrt2 genes is impaired in nitrate uptake. Filleur, S., Dorbe, M.F., Cerezo, M., Orsel, M., Granier, F., Gojon, A., Daniel-Vedele, F. FEBS Lett. (2001) [Pubmed]
  8. Eukaryotic nitrate and nitrite transporters. Galvan, A., Fernández, E. Cell. Mol. Life Sci. (2001) [Pubmed]
  9. High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1. Okamoto, M., Kumar, A., Li, W., Wang, Y., Siddiqi, M.Y., Crawford, N.M., Glass, A.D. Plant Physiol. (2006) [Pubmed]
  10. Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis. Pourtau, N., Jennings, R., Pelzer, E., Pallas, J., Wingler, A. Planta (2006) [Pubmed]
  11. Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana. Wirth, J., Chopin, F., Santoni, V., Viennois, G., Tillard, P., Krapp, A., Lejay, L., Daniel-Vedele, F., Gojon, A. J. Biol. Chem. (2007) [Pubmed]
  12. Two families of acyl-CoA thioesterases in Arabidopsis. Tilton, G., Shockey, J., Browse, J. Biochem. Soc. Trans. (2000) [Pubmed]
  13. Dissection of the AtNRT2.1:AtNRT2.2 Inducible High-Affinity Nitrate Transporter Gene Cluster. Li, W., Wang, Y., Okamoto, M., Crawford, N.M., Siddiqi, M.Y., Glass, A.D. Plant Physiol. (2007) [Pubmed]
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