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Gene Review

STX7  -  syntaxin 7

Homo sapiens

Synonyms: Syntaxin-7
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Disease relevance of STX7


High impact information on STX7


Biological context of STX7


Anatomical context of STX7

  • Syntaxin 7 is a SNARE (soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptor) protein that is present and active in D. discoideum endosomes [Bogdanovic, Bruckert, Morio and Satre (2000) J. Biol. Chem. 275, 36691-36697] [9].
  • A bacterially expressed human Syntaxin 7 lacking the transmembrane domain inhibited homotypic late endosome and lysosome fusion as well as heterotypic late endosome-lysosome fusion [5].
  • In vitro binding studies reveal that syntaxin 7 binds alphaSNAP, a key regulator of transport vesicle fusion at multiple stages of the secretory pathway [7].
  • Based on its homology to yeast and plant vacuolar syntaxins, we propose that syntaxin 7 has a role in vesicle trafficking between the Golgi complex and lysosomes [7].
  • Syntaxin 7 was not expressed in undifferentiated HL-60 cells, but its expression was induced on neutrophil differentiation [10].

Physical interactions of STX7


Other interactions of STX7

  • Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking [6].
  • Overexpression of the myc-tagged protein resulted in an anomalous staining pattern of SNARE molecules participating in ER-Golgi transport such as syntaxin 5 and mammalian bet1, but not the endosomal SNARE syntaxin 7 [12].

Analytical, diagnostic and therapeutic context of STX7


  1. Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. Wade, N., Bryant, N.J., Connolly, L.M., Simpson, R.J., Luzio, J.P., Piper, R.C., James, D.E. J. Biol. Chem. (2001) [Pubmed]
  2. Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA. Suzuki, J., Ohnishi, H., Wada, A., Hirayama, T., Ohno, H., Ueda, N., Yasuda, H., Iiri, T., Wada, Y., Futai, M., Mashima, H. J. Biol. Chem. (2003) [Pubmed]
  3. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. Strömberg, S., Agnarsdóttir, M., Magnusson, K., Rexhepaj, E., Bolander, A., Lundberg, E., Asplund, A., Ryan, D., Rafferty, M., Gallagher, W.M., Uhlen, M., Bergqvist, M., Ponten, F. J. Proteome Res. (2009) [Pubmed]
  4. The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. Antonin, W., Dulubova, I., Arac, D., Pabst, S., Plitzner, J., Rizo, J., Jahn, R. J. Biol. Chem. (2002) [Pubmed]
  5. Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. Ward, D.M., Pevsner, J., Scullion, M.A., Vaughn, M., Kaplan, J. Mol. Biol. Cell (2000) [Pubmed]
  6. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Prekeris, R., Yang, B., Oorschot, V., Klumperman, J., Scheller, R.H. Mol. Biol. Cell (1999) [Pubmed]
  7. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. Wang, H., Frelin, L., Pevsner, J. Gene (1997) [Pubmed]
  8. Relationship between endosomes and lysosomes. Luzio, J.P., Mullock, B.M., Pryor, P.R., Lindsay, M.R., James, D.E., Piper, R.C. Biochem. Soc. Trans. (2001) [Pubmed]
  9. Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum. Bogdanovic, A., Bennett, N., Kieffer, S., Louwagie, M., Morio, T., Garin, J., Satre, M., Bruckert, F. Biochem. J. (2002) [Pubmed]
  10. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. Martín-Martín, B., Nabokina, S.M., Lazo, P.A., Mollinedo, F. J. Leukoc. Biol. (1999) [Pubmed]
  11. A syntaxin 7 homologue is present in Dictyostelium discoideum endosomes and controls their homotypic fusion. Bogdanovic, A., Bruckert, F., Morio, T., Satre, M. J. Biol. Chem. (2000) [Pubmed]
  12. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. Tang, B.L., Low, D.Y., Hong, W. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim, B.Y., Krämer, H., Yamamoto, A., Kominami, E., Kohsaka, S., Akazawa, C. J. Biol. Chem. (2001) [Pubmed]
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