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Gene Review

ERH3  -  ATPase katanin p60

Arabidopsis thaliana

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High impact information on ERH3

  • One of the mechanisms plants have developed for chloroplast protection against oxidative damage involves a 2-Cys peroxiredoxin, which has been proposed to be reduced by ferredoxin and plastid thioredoxins, Trx x and CDSP32, the FTR/Trx pathway [1].
  • Alteration of oriented deposition of cellulose microfibrils by mutation of a katanin-like microtubule-severing protein [2].
  • In addition, the thickness of both primary and secondary cell walls was reduced significantly in the fra2 mutant [2].
  • Consistent with the putative function of AtKTN1 as a microtubule-severing protein, immunolocalization demonstrated that the fra2 mutation caused delays in the disappearance of perinuclear microtubule array and in the establishment of transverse cortical microtubule array in interphase and elongating cells [3].
  • Anatomical and chemical analyses showed that the fra2 mutation caused a reduction in fiber cell length and wall thickness, a decrease in cellulose and hemicellulose contents, and an increase in lignin condensation, indicating that the fragile fiber phenotype of fra2 is a result of alterations in fiber cell elongation and cell wall biosynthesis [3].

Biological context of ERH3

  • The pattern of cell differentiation and the expression of molecular markers of cell fate is altered in the ectopic root hair 3 (erh3) mutant epidermis indicating that ERH3 is required for the specification of cell fates from early in development (in the meristem) through differentiation [4].
  • Hormonal responses of lue1 to ethylene and gibberellins revealed inappropriate cortical microtubule reorientation during cell growth [5].
  • Bot1 roots still show a gravitropic response, which indicates that ordered cortical microtubules are not required for differential growth during gravitropism [6].
  • Recent data have revealed that the thale cress (Arabidopsis thaliana) contains a protein related to the p60 catalytic subunit of animal katanin, a microtubule-severing protein [7].
  • SSLP-based mapping localized lue1 to chromosome I near the ga2 locus, although complementation analyzes showed that lue1 is not allelic to ga2 [8].

Anatomical context of ERH3

  • A katanin-like protein regulates normal cell wall biosynthesis and cell elongation [3].
  • Katanin, a heterodimeric protein with ATP-dependent microtubule-severing activity, localizes to the centrosome in animal cells [9].
  • To evaluate potential interactions between AtKSS and the cytoskeleton, the intracellular localization of AtKSS was correlated with that of tubulin [9].

Associations of ERH3 with chemical compounds


Other interactions of ERH3

  • In a screen designed to identify genes in the specification of epidermal cell fate in Arabidopsis primary roots we have isolated 8 new mutants that fall into 6 complementation groups corresponding to the 'root hairless' genes RHL1, RHL2 and RHL3 and the 'ectopic root hair' genes ERH1, ERH2 and ERH3 [11].
  • A yeast two-hybrid screen with AtKSS as the bait identified proteins related to those involved in microtubule processing, including a katanin p80 subunit and a kinesin ortholog [5].

Analytical, diagnostic and therapeutic context of ERH3


  1. Rice NTRC Is a High-Efficiency Redox System for Chloroplast Protection against Oxidative Damage. Pérez-Ruiz, J.M., Spínola, M.C., Kirchsteiger, K., Moreno, J., Sahrawy, M., Cejudo, F.J. Plant Cell (2006) [Pubmed]
  2. Alteration of oriented deposition of cellulose microfibrils by mutation of a katanin-like microtubule-severing protein. Burk, D.H., Ye, Z.H. Plant Cell (2002) [Pubmed]
  3. A katanin-like protein regulates normal cell wall biosynthesis and cell elongation. Burk, D.H., Liu, B., Zhong, R., Morrison, W.H., Ye, Z.H. Plant Cell (2001) [Pubmed]
  4. Cell specification in the Arabidopsis root epidermis requires the activity of ECTOPIC ROOT HAIR 3--a katanin-p60 protein. Webb, M., Jouannic, S., Foreman, J., Linstead, P., Dolan, L. Development (2002) [Pubmed]
  5. The Arabidopsis lue1 mutant defines a katanin p60 ortholog involved in hormonal control of microtubule orientation during cell growth. Bouquin, T., Mattsson, O., Naested, H., Foster, R., Mundy, J. J. Cell. Sci. (2003) [Pubmed]
  6. BOTERO1 is required for normal orientation of cortical microtubules and anisotropic cell expansion in Arabidopsis. Bichet, A., Desnos, T., Turner, S., Grandjean, O., Höfte, H. Plant J. (2001) [Pubmed]
  7. Functional evidence for in vitro microtubule severing by the plant katanin homologue. Stoppin-Mellet, V., Gaillard, J., Vantard, M. Biochem. J. (2002) [Pubmed]
  8. Gibberellin response mutants identified by luciferase imaging. Meier, C., Bouquin, T., Nielsen, M.E., Raventos, D., Mattsson, O., Rocher, A., Schomburg, F., Amasino, R.M., Mundy, J. Plant J. (2001) [Pubmed]
  9. cDNA isolation, characterization, and protein intracellular localization of a katanin-like p60 subunit from Arabidopsis thaliana. McClinton, R.S., Chandler, J.S., Callis, J. Protoplasma (2001) [Pubmed]
  10. Hypersensitivity to cytoskeletal antagonists demonstrates microtubule-microfilament cross-talk in the control of root elongation in Arabidopsis thaliana. Collings, D.A., Lill, A.W., Himmelspach, R., Wasteneys, G.O. New Phytol. (2006) [Pubmed]
  11. Structural and genetic analysis of epidermal cell differentiation in Arabidopsis primary roots. Schneider, K., Wells, B., Dolan, L., Roberts, K. Development (1997) [Pubmed]
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