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Gene Review

RCK2  -  Rck2p

Saccharomyces cerevisiae S288c

Synonyms: CAM kinase-like protein kinase CLK1, CLK1, CMK3, L9672.6, Serine/threonine-protein kinase RCK2, ...
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Disease relevance of RCK2

  • Rck2 T379E was sufficiently inactive in an rck2Delta strain to allow some cells to survive PBS2DD toxicity even when overexpressed [1].

High impact information on RCK2


Biological context of RCK2


Anatomical context of RCK2


Associations of RCK2 with chemical compounds


Physical interactions of RCK2

  • Both two-hybrid analyses and coprecipitation assays demonstrated that Hog1 binds strongly to the C-terminal region of Rck2 [10].

Regulatory relationships of RCK2

  • This modification depended on catalytically active Hog1 kinase and two putative mitogen-activated protein kinase phosphorylation sites in Rck2 [3].

Other interactions of RCK2

  • Consistently, growth arrest caused by hyperactivation of the Hog1 MAPK was abolished by deletion of the RCK2 gene [10].
  • Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4 [11].

Analytical, diagnostic and therapeutic context of RCK2

  • We have also identified a CLK2 autophosphorylation site, which is highly conserved among all CLK proteins, and we show by site-directed mutagenesis that its phosphorylation influences the subnuclear localization of CLK2 [12].
  • Using active recombinant proteins and a surface plasmon resonance based detection technique, we demonstrated that the three members of this subfamily of kinases (CLK1, 2, and 4) all interact with beacon [13].


  1. Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cerevisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379. Jiang, L., Niu, S., Clines, K.L., Burke, D.J., Sturgill, T.W. Mol. Genet. Genomics (2004) [Pubmed]
  2. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. Felkai, S., Ewbank, J.J., Lemieux, J., Labbé, J.C., Brown, G.G., Hekimi, S. EMBO J. (1999) [Pubmed]
  3. Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast. Teige, M., Scheikl, E., Reiser, V., Ruis, H., Ammerer, G. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae. Melcher, M.L., Thorner, J. J. Biol. Chem. (1996) [Pubmed]
  5. Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Bilsland, E., Molin, C., Swaminathan, S., Ramne, A., Sunnerhagen, P. Mol. Microbiol. (2004) [Pubmed]
  6. The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast. Ramne, A., Bilsland-Marchesan, E., Erickson, S., Sunnerhagen, P. Mol. Gen. Genet. (2000) [Pubmed]
  7. Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae. Dahlkvist, A., Sunnerhagen, P. Gene (1994) [Pubmed]
  8. The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe. Dahlkvist, A., Kanter-Smoler, G., Sunnerhagen, P. Mol. Gen. Genet. (1995) [Pubmed]
  9. Rck2 is required for reprogramming of ribosomes during oxidative stress. Swaminathan, S., Masek, T., Molin, C., Pospisek, M., Sunnerhagen, P. Mol. Biol. Cell (2006) [Pubmed]
  10. Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1. Bilsland-Marchesan, E., Ariño, J., Saito, H., Sunnerhagen, P., Posas, F. Mol. Cell. Biol. (2000) [Pubmed]
  11. Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4. Swaminathan, S., Sunnerhagen, P. Mol. Genet. Genomics (2005) [Pubmed]
  12. The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. Nayler, O., Schnorrer, F., Stamm, S., Ullrich, A. J. Biol. Chem. (1998) [Pubmed]
  13. Beacon interacts with cdc2/cdc28-like kinases. Kantham, L., Kerr-Bayles, L., Godde, N., Quick, M., Webb, R., Sunderland, T., Bond, J., Walder, K., Augert, G., Collier, G. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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