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Gene Review

ADK1  -  adenylate kinase ADK1

Saccharomyces cerevisiae S288c

Synonyms: AKY, AKY1, AKY2, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, ...
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Disease relevance of ADK1


High impact information on ADK1

  • A Ura6 mutant protein in which helix 5 had been replaced with the respective sequence from Aky2p was imported, and this address sequence cooperates with the N terminus in the respective double mutant in a synergistic fashion [2].
  • Yeast adenylate kinase (Aky2p, Adk1p) occurs simultaneously in cytoplasm and mitochondrial intermembrane space [2].
  • The extreme N terminus of Aky2p is able to direct cytoplasmic passengers to mitochondria [2].
  • Thus, nascent Adk1p/Aky2p has two options: either it is synthesized to completion and folds into an enzymatically active import-incompetent conformation that remains in the cytosol; or, during synthesis and before commencement of significant tertiary structure formation, it reaches a mitochondrial surface receptor and is internalized [3].
  • This is in contrast to the ADK1 gene of S. cerevisiae, the deletion of which was shown to lead to a slower cell growth rate rather than to a lethal phenotype [4].

Biological context of ADK1


Associations of ADK1 with chemical compounds

  • ADK1 was found to be identical to an adenylate kinase gene recently isolated by an approach entirely different from ours (Magdolen, V., Oechsner, U., and Bandlow, W. (1987) Curr. Genet. 12, 405-411) [5].
  • Methanol-induced transformants had 10,000-fold enhanced levels of ADK activity and produced 23-fold more ATP from adenosine when compared to the control, parent strain [7].

Analytical, diagnostic and therapeutic context of ADK1


  1. Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae. Schricker, R., Magdolen, V., Strobel, G., Bogengruber, E., Breitenbach, M., Bandlow, W. J. Biol. Chem. (1995) [Pubmed]
  2. Redundant mitochondrial targeting signals in yeast adenylate kinase. Schricker, R., Angermayr, M., Strobel, G., Klinke, S., Korber, D., Bandlow, W. J. Biol. Chem. (2002) [Pubmed]
  3. Competition of spontaneous protein folding and mitochondrial import causes dual subcellular location of major adenylate kinase. Strobel, G., Zollner, A., Angermayr, M., Bandlow, W. Mol. Biol. Cell (2002) [Pubmed]
  4. Molecular analysis of the essential gene for adenylate kinase from the fission yeast Schizosaccharomyces pombe. Konrad, M. J. Biol. Chem. (1993) [Pubmed]
  5. Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. Konrad, M. J. Biol. Chem. (1988) [Pubmed]
  6. Expression of Saccharomyces adenylate kinase gene in Candida boidinii under the regulation of its alcohol oxidase promoter. Sakai, Y., Rogi, T., Takeuchi, R., Kato, N., Tani, Y. Appl. Microbiol. Biotechnol. (1995) [Pubmed]
  7. High-level ATP production by a genetically-engineered Candida yeast. Sakai, Y., Rogi, T., Yonehara, T., Kato, N., Tani, Y. Biotechnology (N.Y.) (1994) [Pubmed]
  8. In vivo import of yeast adenylate kinase into mitochondria affected by site-directed mutagenesis. Magdolen, V., Schricker, R., Strobel, G., Germaier, H., Bandlow, W. FEBS Lett. (1992) [Pubmed]
  9. Cytoplasmic and mitochondrial forms of yeast adenylate kinase 2 are N-acetylated. Klier, H., Magdolen, V., Schricker, R., Strobel, G., Lottspeich, F., Bandlow, W. Biochim. Biophys. Acta (1996) [Pubmed]
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