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DPP1  -  bifunctional diacylglycerol diphosphate...

Saccharomyces cerevisiae S288c

Synonyms: DGPP phosphatase, Diacylglycerol pyrophosphate phosphatase 1, Phosphatidate phosphatase, YDR284C, ZRG1
 
 
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Disease relevance of DPP1

 

High impact information on DPP1

 

Biological context of DPP1

  • The expression of a membrane-associated form of phosphatidate phosphatase is regulated by growth phase and inositol supplementation, whereas enzyme activity is regulated by lipids, nucleotides, and by phosphorylation [1].
  • Analysis of DPP1 expression using PDPP1-lacZ reporter genes with a series of deletions from the 5' end of the promoter indicated sequences responsible for enzyme expression [5].
  • Disruption of either LPP1 or DPP1 caused respective decreases of about 25 and 75% in Mg2+-independent hydrolysis of several isoprenoid phosphates by particulate fractions isolated from these cells [6].
  • Multicopy plasmids containing the DPP1 gene directed a 10-fold overexpression of DGPP phosphatase activity in S. cerevisiae [7].
  • Three binding sites (URSPDS) for transcription factor Gis1p were identified in the DPP1 promoter (consensus sequence of 5'-T(A/T)AGGGAT-3') [5].
 

Anatomical context of DPP1

 

Associations of DPP1 with chemical compounds

 

Regulatory relationships of DPP1

  • Under zinc-deplete conditions, the positive transcription factor Zap1p stimulates the expression of the DPP1 and PIS1 genes through the cis-acting element UAS(ZRE) [13].
 

Other interactions of DPP1

  • The LPP1 gene product also exhibited lyso-PA phosphatase and DGPP phosphatase activities [11].
  • This regulation was dependent on the UAS(ZRE) in the DPP1 promoter and was mediated by the Zap1p transcriptional activator [8].
  • Repression of DPP1 expression is mediated by the transcription factor Gis1p, which binds to three post-diauxic shift elements in the promoter [14].
  • Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP [15].
 

Analytical, diagnostic and therapeutic context of DPP1

References

  1. Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli. Carman, G.M. Biochim. Biophys. Acta (1997) [Pubmed]
  2. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Carman, G.M., Han, G.S. Trends Biochem. Sci. (2006) [Pubmed]
  3. Vacuole membrane topography of the DPP1-encoded diacylglycerol pyrophosphate phosphatase catalytic site from Saccharomyces cerevisiae. Han, G.S., Johnston, C.N., Carman, G.M. J. Biol. Chem. (2004) [Pubmed]
  4. Regulation of phospholipid synthesis in the yeast cki1Delta eki1Delta mutant defective in the Kennedy pathway. The Cho1-encoded phosphatidylserine synthase is regulated by mRNA stability. Choi, H.S., Sreenivas, A., Han, G.S., Carman, G.M. J. Biol. Chem. (2004) [Pubmed]
  5. Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. Oshiro, J., Han, G.S., Iwanyshyn, W.M., Conover, K., Carman, G.M. J. Biol. Chem. (2003) [Pubmed]
  6. The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae. Faulkner, A., Chen, X., Rush, J., Horazdovsky, B., Waechter, C.J., Carman, G.M., Sternweis, P.C. J. Biol. Chem. (1999) [Pubmed]
  7. Isolation and characterization of the Saccharomyces cerevisiae DPP1 gene encoding diacylglycerol pyrophosphate phosphatase. Toke, D.A., Bennett, W.L., Dillon, D.A., Wu, W.I., Chen, X., Ostrander, D.B., Oshiro, J., Cremesti, A., Voelker, D.R., Fischl, A.S., Carman, G.M. J. Biol. Chem. (1998) [Pubmed]
  8. Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc. Han, G.S., Johnston, C.N., Chen, X., Athenstaedt, K., Daum, G., Carman, G.M. J. Biol. Chem. (2001) [Pubmed]
  9. Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. Wu, W.I., Liu, Y., Riedel, B., Wissing, J.B., Fischl, A.S., Carman, G.M. J. Biol. Chem. (1996) [Pubmed]
  10. Phosphatidate phosphatase from yeast mitochondria. Carman, G.M., Quinlan, J.J. Meth. Enzymol. (1992) [Pubmed]
  11. Isolation and characterization of the Saccharomyces cerevisiae LPP1 gene encoding a Mg2+-independent phosphatidate phosphatase. Toke, D.A., Bennett, W.L., Oshiro, J., Wu, W.I., Voelker, D.R., Carman, G.M. J. Biol. Chem. (1998) [Pubmed]
  12. The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiae. Fernandez, F., Rush, J.S., Toke, D.A., Han, G.S., Quinn, J.E., Carman, G.M., Choi, J.Y., Voelker, D.R., Aebi, M., Waechter, C.J. J. Biol. Chem. (2001) [Pubmed]
  13. Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. Carman, G.M., Han, G.S. Biochim. Biophys. Acta (2007) [Pubmed]
  14. Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae. Oshiro, J., Han, G.S., Carman, G.M. Biochim. Biophys. Acta (2003) [Pubmed]
  15. Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP. Oshiro, J., Rangaswamy, S., Chen, X., Han, G.S., Quinn, J.E., Carman, G.M. J. Biol. Chem. (2000) [Pubmed]
 
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