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Gene Review

FOX2  -  bifunctional hydroxyacyl-CoA...

Saccharomyces cerevisiae S288c

Synonyms: HDE, MFP, Multifunctional beta-oxidation protein, Peroxisomal hydratase-dehydrogenase-epimerase, YK108, ...
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High impact information on FOX2

  • Growth of a yeast fox2sps19Delta mutant in which Fox2p was exchanged with rat peroxisomal multifunctional enzyme type 1 on trans-9,trans-12 linolelaidic acid medium gave credence to this theory [1].
  • The gene encoding the multifunctional protein (MFP) of peroxisomal beta-oxidation in Saccharomyces cerevisiae was isolated from a genomic library via functional complementation of a fox2 mutant strain [2].
  • Substitutions within the carboxyl-terminal tripeptide (Ala----Gly and Lys----Gln) supported targeting of HDE to peroxisomes of C. albicans but not of S. cerevisiae [3].
  • We have investigated the regulation of expression of the gene (HDE), encoding the peroxisomal trifunctional enzyme hydratase-dehydrogenase-epimerase (HDE), of the diploid yeast Candida tropicalis [4].
  • The gene (HDE) encoding the peroxisomal trifunctional enzyme, hydratase-dehydrogenase-epimerase, of the yeast Candida tropicalis, was cloned and its nucleotide sequence is reported [5].

Biological context of FOX2


Anatomical context of FOX2

  • Deletion and mutational analyses were used to determine the regions within HDE which are essential for its targeting to peroxisomes [3].
  • We have previously reported preclinical studies in mice of the human mucin 1 (MUC1) antigen covalently linked to the yeast cell-wall mannan polysaccharide (MFP), and shown strong cellular responses of the T1 type using mice [8].

Associations of FOX2 with chemical compounds


Analytical, diagnostic and therapeutic context of FOX2


  1. Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae. Gurvitz, A., Hamilton, B., Ruis, H., Hartig, A. J. Biol. Chem. (2001) [Pubmed]
  2. Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. Hiltunen, J.K., Wenzel, B., Beyer, A., Erdmann, R., Fosså, A., Kunau, W.H. J. Biol. Chem. (1992) [Pubmed]
  3. The carboxyl-terminal tripeptide Ala-Lys-Ile is essential for targeting Candida tropicalis trifunctional enzyme to yeast peroxisomes. Aitchison, J.D., Murray, W.W., Rachubinski, R.A. J. Biol. Chem. (1991) [Pubmed]
  4. Glucose-responsive and oleic acid-responsive elements in the gene encoding the peroxisomal trifunctional enzyme of Candida tropicalis. Sloots, J.A., Aitchison, J.D., Rachubinski, R.A. Gene (1991) [Pubmed]
  5. Sequence of the gene encoding Candida tropicalis peroxisomal trifunctional enzyme. Aitchison, J.D., Sloots, J.A., Nuttley, W.M., Rachubinski, R.A. Gene (1991) [Pubmed]
  6. Molecular cloning, sequencing and sequence analysis of the fox-2 gene of Neurospora crassa encoding the multifunctional beta-oxidation protein. Fosså, A., Beyer, A., Pfitzner, E., Wenzel, B., Kunau, W.H. Mol. Gen. Genet. (1995) [Pubmed]
  7. cDNA cloning and primary structure determination of the peroxisomal trifunctional enzyme hydratase-dehydrogenase-epimerase from the yeast Candida tropicalis pK233. Nuttley, W.M., Aitchison, J.D., Rachubinski, R.A. Gene (1988) [Pubmed]
  8. Parameters for using mannan-MUC1 fusion protein to induce cellular immunity. Pietersz, G.A., Li, W., Popovski, V., Caruana, J.A., Apostolopoulos, V., McKenzie, I.F. Cancer Immunol. Immunother. (1998) [Pubmed]
  9. Dehydroepiandrosterone (DHEA) metabolism in Saccharomyces cerevisiae expressing mammalian steroid hydroxylase CYP7B: Ayr1p and Fox2p display 17beta-hydroxysteroid dehydrogenase activity. Vico, P., Cauet, G., Rose, K., Lathe, R., Degryse, E. Yeast (2002) [Pubmed]
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