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Gene Review

CDKL2  -  cyclin-dependent kinase-like 2 (CDC2...

Homo sapiens

Synonyms: Cyclin-dependent kinase-like 2, KKIAMRE, P56, Protein kinase p56 KKIAMRE, Serine/threonine-protein kinase KKIAMRE
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Disease relevance of CDKL2


Psychiatry related information on CDKL2

  • However, stress-induced locomotor activity was significantly increased in the Caesarean birth plus anoxia at P35, while after puberty (at P56), saline injection, D-amphetamine and stress-induced locomotion were significantly enhanced in the Caesarean birth plus anoxia compared to its control groups [4].

High impact information on CDKL2

  • In contrast, wild-type mice receiving the same doses of rhGH exhibited accelerated growth starting at P21 that continued until P56, when their body weight was increased by 30% and length by 12% compared with control mice treated with diluent [3].
  • Secreted FZD-related protein-2 (SFRP2), a WNT antagonist, was not detected in the P0 uterus, but was abundant in the aglandular caruncular areas of the endometrium between P7 and P56 [5].
  • P56 is the most abundant protein induced by interferon (IFN) treatment of human cells [1].
  • P56 synthesis was rapidly induced by IFN-beta, and the protein had a half-life of 6 h [1].
  • Induction of P56 in the P2.1 cells and the parental U4C cells by virus infection was preceded by activation of IRF-3 as judged by its translocation to the nucleus from the cytoplasm [1].

Biological context of CDKL2

  • [J. Opt. Soc. Am. A 3(13), P56 (1986)] was applied to contrast-sensitivity data from 100 older subjects (ages 53-85 years) [6].
  • A perfect TATA Box consensus sequence 30 bp further upstream, which is highly conserved among HPVs associated with cervical cancer, was required for the activity of this novel promoter, denoted here as P56 [7].

Anatomical context of CDKL2

  • We detected transcripts initiating from both the P105 and the P56 in primary keratinocytes harboring episomal HPV18 as well as in the HPV 18 positive cervical carcinoma cell lines HeLa, C4-1 and SW756 [7].

Associations of CDKL2 with chemical compounds

  • In contrast, the activity responsible for the conversion of P56 into P50 was inhibited by each of the cysteine protease inhibitors E-64, leupeptin and iodoacetoamide [8].

Analytical, diagnostic and therapeutic context of CDKL2


  1. Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection. Guo, J., Peters, K.L., Sen, G.C. Virology (2000) [Pubmed]
  2. Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus. Guo, J., Sen, G.C. J. Virol. (2000) [Pubmed]
  3. Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Liu, J.L., LeRoith, D. Endocrinology (1999) [Pubmed]
  4. Anoxia at birth induced hyperresponsiveness to amphetamine and stress in postpubertal rats. Juárez, I., Silva-Gómez, A.B., Peralta, F., Flores, G. Brain Res. (2003) [Pubmed]
  5. WNT pathways in the neonatal ovine uterus: potential specification of endometrial gland morphogenesis by SFRP2. Hayashi, K., Spencer, T.E. Biol. Reprod. (2006) [Pubmed]
  6. Modeling the contrast-sensitivity functions of older adults. Rohaly, A.M., Owsley, C. Journal of the Optical Society of America. A, Optics and image science. (1993) [Pubmed]
  7. Identification of a promoter in position 56 within the long control region of human papillomavirus type 18. Steger, G., Rehtanz, M., Schnabel, C. Arch. Virol. (2001) [Pubmed]
  8. Characterization of proteases involved in the processing of Plasmodium falciparum serine repeat antigen (SERA). Li, J., Matsuoka, H., Mitamura, T., Horii, T. Mol. Biochem. Parasitol. (2002) [Pubmed]
  9. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. Taglienti, C.A., Wysk, M., Davis, R.J. Oncogene (1996) [Pubmed]
  10. A new pathway of translational regulation mediated by eukaryotic initiation factor 3. Guo, J., Hui, D.J., Merrick, W.C., Sen, G.C. EMBO J. (2000) [Pubmed]
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