The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SART1  -  squamous cell carcinoma antigen recognized...

Homo sapiens

Synonyms: Ara1, HOMS1, SART-1, SART1259, SNRNP110, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SART1


Psychiatry related information on SART1

  • We also show that errors (false presses) on the SART can be predicted by a significant shortening of reaction times in the immediately preceding responses, supporting the view that these errors are a result of 'drift' of controlled processing into automatic responding consequent on impaired sustained attention to task [5].

High impact information on SART1

  • In this paper, we describe the chromosomal localization of the gene for squamous cell carcinoma-associated reactive antigen for cytotoxic T cells (SART-1) [6].
  • We therefore hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy [6].
  • SART1 and heterogeneous nuclear RNP M were both shown to be genuine SUMO targets, confirming the validity of the approach [7].
  • Both the U5-specific, TPR/HAT-repeat-containing hPrp6 protein and the tri-snRNP-specific hSnu66 protein interact with several U5- and U4/U6-associated proteins, including hBrr2 and hPrp3, which contacts the U6 snRNA [8].
  • HLA-A24-restricted and SART1-specific CTLs recognized the HLA-A24+ and SART1(259)+ glioma cells, and the levels of recognition correlated both with HLA-A24-antigen expression level and with the concentration of the SART1 peptide antigen [4].

Biological context of SART1


Anatomical context of SART1


Associations of SART1 with chemical compounds

  • We have also developed a new L-shaped titanium plate (HOMS Engineering Inc., Nagano, Japan) that fits into the fixation unit [13].
  • Lidocaine had no consistent effects on sinus rate, SART, atrial refractoriness, or A-V nodal conduction as measured by pooled AH intervals and the Wenckebach point, and on A-V nodal refractoriness [14].
  • In particular, retardation of absorbance increase at 234 nm as formation of the conjugated diene hydroperoxides in a real pork oil system stored at 60 degrees C, supplement of Ara-1 at 100 microM has shown equivalent or even greater activity than did BHT [15].
  • During incubation of the peanut slices, contents of Res, Ara-1, and Ara-3 increased tremendously from initially trace or not detectable amounts up to 147.3, 495.7, and 2414.8 microg/g, corresponding to 20, 16, and 24 h of incubation, while IPD contents continued to increase up to 28 h (4474.4 microg/g) [15].

Other interactions of SART1


Analytical, diagnostic and therapeutic context of SART1


  1. Expression of the SART1 tumor-rejection antigen in human osteosarcomas. Ishida, H., Komiya, S., Inoue, Y., Yutani, S., Inoue, A., Itoh, K. Int. J. Oncol. (2000) [Pubmed]
  2. Expression of the SART1 tumor-rejection antigens in colorectal cancers. Sasatomi, T., Yamana, H., Shichijo, S., Tanaka, S., Okamura, T., Ogata, Y., Itoh, K., Shirouzu, K. Dis. Colon Rectum (2000) [Pubmed]
  3. Expression of the SART1 tumor rejection antigen in renal cell carcinoma. Shintaku, I., Kawagoe, N., Yutani, S., Hoshi, S., Orikasa, S., Yoshizumi, O., Itoh, K. Urol. Res. (2000) [Pubmed]
  4. Expression of the tumor-rejection antigen SART1 in brain tumors. Imaizumi, T., Kuramoto, T., Matsunaga, K., Shichijo, S., Yutani, S., Shigemori, M., Oizumi, K., Itoh, K. Int. J. Cancer (1999) [Pubmed]
  5. 'Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects. Robertson, I.H., Manly, T., Andrade, J., Baddeley, B.T., Yiend, J. Neuropsychologia. (1997) [Pubmed]
  6. Identification of the autoantigen SART-1 as a candidate gene for the development of atopy. Wheatley, A.P., Bolland, D.J., Hewitt, J.E., Dewar, J.C., Hall, I.P. Hum. Mol. Genet. (2002) [Pubmed]
  7. A proteomic study of SUMO-2 target proteins. Vertegaal, A.C., Ogg, S.C., Jaffray, E., Rodriguez, M.S., Hay, R.T., Andersen, J.S., Mann, M., Lamond, A.I. J. Biol. Chem. (2004) [Pubmed]
  8. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. Liu, S., Rauhut, R., Vornlocher, H.P., Lührmann, R. RNA (2006) [Pubmed]
  9. Cytokines required for induction of histocompatibility leukocyte antigen-class I-restricted and tumor-specific cytotoxic T lymphocytes by a SART1-derived peptide. Matsunaga, K., Nakao, M., Masuoka, K., Inoue, Y., Gouhara, R., Imaizumi, T., Nishizaka, S., Itoh, K. Jpn. J. Cancer Res. (1999) [Pubmed]
  10. Cell cycle arrest and apoptosis induced by SART-1 gene transduction. Hosokawa, M., Kadota, R., Shichijo, S., Itoh, K., Dmitriev, I., Krasnykh, V., Curiel, D.T., Takue, Y., Wakasugi, H., Takashima, S., Heike, Y. Anticancer Res. (2005) [Pubmed]
  11. Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast. Yashiroda, H., Tanaka, K. Genes Cells (2004) [Pubmed]
  12. Generation of a human leukocyte antigen-A24-restricted antitumor cell with the use of SART-1 peptide and dendritic cells in patients with malignant brain tumors. Yoshida, S., Tanaka, R. J. Lab. Clin. Med. (2004) [Pubmed]
  13. A new technique for cranioplasty with L-shaped titanium plates and combination ceramic implants composed of hydroxyapatite and tricalcium phosphate (Ceratite). Miyake, H., Ohta, T., Tanaka, H. Neurosurgery (2000) [Pubmed]
  14. Effects of lidocaine on impulse formation and conduction defects in man. Roos, J.C., Dunning, A.J. Am. Heart J. (1975) [Pubmed]
  15. Biosynthesis enhancement and antioxidant and anti-inflammatory activities of peanut (Arachis hypogaea L.) arachidin-1, arachidin-3, and isopentadienylresveratrol. Chang, J.C., Lai, Y.H., Djoko, B., Wu, P.L., Liu, C.D., Liu, Y.W., Chiou, R.Y. J. Agric. Food Chem. (2006) [Pubmed]
  16. Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma. Uemura, M., Nouso, K., Kobayashi, Y., Tanaka, H., Nakamura, S., Higashi, T., Ono, T., Nakayama, E., Hanafusa, T., Shiratori, Y. Cancer (2003) [Pubmed]
  17. Study of HLA class I restriction and the directed antigens of cytotoxic T lymphocytes at the tumor sites of ovarian cancer. Yamada, A., Kawano, K., Harashima, N., Niiya, F., Nagai, K., Kobayashi, T., Mine, T., Ushijima, K., Nishida, T., Itoh, K. Cancer Immunol. Immunother. (1999) [Pubmed]
  18. Distinct and Overlapping Sets of SUMO-1 and SUMO-2 Target Proteins Revealed by Quantitative Proteomics. Vertegaal, A.C., Andersen, J.S., Ogg, S.C., Hay, R.T., Mann, M., Lamond, A.I. Mol. Cell Proteomics (2006) [Pubmed]
WikiGenes - Universities