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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genes, Neoplasm

 
 
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Disease relevance of Genes, Neoplasm

 

High impact information on Genes, Neoplasm

  • These results suggest that combined delivery of two cooperating genes like p16 and p53 could be the basis for the development of a new strategy for cancer gene therapy [6].
  • These data suggest that viral vector transduction of the dCK gene followed by treatment with ara-C represents a new chemosensitization strategy for cancer gene therapy [7].
  • Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history [8].
  • BRCA2 as a low-penetrance cancer gene [9].
  • This evidence now supports the placement of telomerase among the cancer gene elite [10].
 

Chemical compound and disease context of Genes, Neoplasm

 

Biological context of Genes, Neoplasm

  • This may suggest that there is a second tumor suppressor or recessive cancer gene on chromosome 13 in bladder cancer and/or that the mechanism of RB inactivation in bladder cancer frequently involves independent mutations of each RB allele [16].
  • These observations strongly support that p16INK4 is a tumor suppressor gene and is a candidate for cancer gene replacement therapy [17].
  • The finding of frequent epigenetic inactivation of RASSF1A in papillary RCCs despite previous studies reporting infrequent 3p21 allele loss in this tumor type illustrates how the systematic identification of all major human cancer genes will require detailed analysis of the cancer genome and epigenome [18].
  • When expressed alone, E4orf4 induces a novel form of p53-independent apoptosis in cancer cells but not in normal human cells, thus making it of potential use in cancer gene therapy [19].
  • We constructed an adenoviral vector containing human p16 cDNA in order to evaluate the cytotoxic effects of exogenous p16 expression on cancer cell proliferation and to explore the potential use of p16 in cancer gene therapy [20].
 

Anatomical context of Genes, Neoplasm

  • To develop a novel cancer gene therapy strategy based on suppression of tumor angiogenesis, we examined the feasibility of targeting and preferential killing of proliferating endothelial cells by use of the von Willebrand factor (vWf) promoter and herpes simplex virus thymidine kinase gene (HSV-TK) [21].
  • This mouse model not only demonstrates the depletion of CD4(+) T cells as a useful strategy for cancer gene therapy with interleukin-12 but also provides a model for human melanoma-associated vitiligo.J Invest Dermatol 115:1059-1064 2000[22]
  • A candidate for cancer gene therapy: MIP-1 alpha gene transfer to an adenocarcinoma cell line reduced tumorigenicity and induced protective immunity in immunocompetent mice [23].
  • Additionally, the characterization of the recovered mutants and a comparison of the mutation spectrum in the rat lymphocyte system to the spectrum in cancer genes, such as H-ras and p53, and the spectrum in transgenic systems, such as lacI, are included [24].
 

Associations of Genes, Neoplasm with chemical compounds

 

Gene context of Genes, Neoplasm

 

Analytical, diagnostic and therapeutic context of Genes, Neoplasm

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