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Gene Review

P2RX6  -  purinergic receptor P2X, ligand gated ion...

Homo sapiens

Synonyms: ATP receptor, MGC129625, P2RXL1, P2X purinoceptor 6, P2X6, ...
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Disease relevance of P2RXL1


High impact information on P2RXL1

  • The assembly of P2X4 with P2X6 subunits results from subunit-dependent interactions, as shown by their specific copurification from HEK-293 cells transiently transfected with various epitope-tagged P2X channel subunits [2].
  • Hence, we designated the gene P2XM (P2X specifically expressed in skeletal muscle) [1].
  • When this region is removed, or when charge is added to it, P2X6 forms homotrimeric assemblies, undergoes complex glycosylation and is delivered to the plasma membrane, albeit less efficiently than the P2X2 receptor [3].
  • We propose that the N terminus of the P2X6 subunit contributes to a mechanism that prevents the inappropriate export and plasma membrane expression of nonfunctional P2X receptors [3].
  • An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum [3].

Biological context of P2RXL1


Anatomical context of P2RXL1


Associations of P2RXL1 with chemical compounds


Other interactions of P2RXL1


  1. Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Urano, T., Nishimori, H., Han, H., Furuhata, T., Kimura, Y., Nakamura, Y., Tokino, T. Cancer Res. (1997) [Pubmed]
  2. Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor. Lê, K.T., Babinski, K., Séguéla, P. J. Neurosci. (1998) [Pubmed]
  3. An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum. Ormond, S.J., Barrera, N.P., Qureshi, O.S., Henderson, R.M., Edwardson, J.M., Murrell-Lagnado, R.D. Mol. Pharmacol. (2006) [Pubmed]
  4. P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. Glass, R., Loesch, A., Bodin, P., Burnstock, G. Cell. Mol. Life Sci. (2002) [Pubmed]
  5. Frequent loss of expression or aberrant alternative splicing of P2XM, a p53-inducible gene, in soft-tissue tumours. Nawa, G., Miyoshi, Y., Yoshikawa, H., Ochi, T., Nakamura, Y. Br. J. Cancer (1999) [Pubmed]
  6. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. Banfi, C., Ferrario, S., De Vincenti, O., Ceruti, S., Fumagalli, M., Mazzola, A., D' Ambrosi, N., Volontè, C., Fratto, P., Vitali, E., Burnstock, G., Beltrami, E., Parolari, A., Polvani, G., Biglioli, P., Tremoli, E., Abbracchio, M.P. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  7. Localized expression of specific P2X receptors in dystrophin-deficient DMD and mdx muscle. Jiang, T., Yeung, D., Lien, C.F., Górecki, D.C. Neuromuscul. Disord. (2005) [Pubmed]
  8. P2X2 receptor mediates stimulation of parasensory cation absorption by cochlear outer sulcus cells and vestibular transitional cells. Lee, J.H., Chiba, T., Marcus, D.C. J. Neurosci. (2001) [Pubmed]
  9. Differential expression of P2X-purinoceptor subtypes in circular and longitudinal muscle of canine colon. Lee, H.K., Ro, S., Keef, K.D., Kathy, K.D., Kim, Y.H., Kim, H.W., Horowitz, B., Sanders, K.M. Neurogastroenterol. Motil. (2005) [Pubmed]
  10. Functional and molecular diversity of purinergic ion channel receptors. MacKenzie, A.B., Surprenant, A., North, R.A. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
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