Gene Review:
P2RX7 - purinergic receptor P2X, ligand gated ion...
Homo sapiens
Synonyms:
ATP receptor, MGC20089, P2X purinoceptor 7, P2X7, P2Z receptor, ...
Ojcius,
de Oliveira Souza,
Witt,
Li,
Taper,
Han,
McVey,
Wiley,
Higgins,
Falzoni,
Buell,
MacKenzie,
Gallo,
Lai,
Park,
Gos,
Dao-Ung,
Vincent,
Chiozzi,
Sluyter,
Liu,
Cheung,
Sluyter,
Manoharan,
Raffaghello,
Elliott,
North,
Shemon,
Antonarakis,
Lorenz,
Lee,
Sluyter,
Talabot,
Di Virgilio,
Gu,
Pistoia,
Hand,
Toner,
Stahl,
Shemon,
Elliott,
Wiley,
Kong,
Surprenant,
North,
Kim,
Burnstock,
Wiley,
Cusick,
Coutinho-Silva,
Menze,
Morris,
de Campos,
- The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Elliott, J.I., McVey, J.H., Higgins, C.F. Arthritis Res. Ther. (2005)
- Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. Greig, A.V., Linge, C., Healy, V., Lim, P., Clayton, E., Rustin, M.H., McGrouther, D.A., Burnstock, G. J. Invest. Dermatol. (2003)
- The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism. Raffaghello, L., Chiozzi, P., Falzoni, S., Di Virgilio, F., Pistoia, V. Cancer Res. (2006)
- Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines. Cowen, D.S., Berger, M., Nuttle, L., Dubyak, G.R. J. Leukoc. Biol. (1991)
- P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E.B., Uhr, M., Paez-Pereda, M., Sillaber, I., Ising, M., Brückl, T., Lieb, R., Holsboer, F., Müller-Myhsok, B. Hum. Mol. Genet. (2006)
- P2X7 receptor modulation of beta-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia. Rampe, D., Wang, L., Ringheim, G.E. J. Neuroimmunol. (2004)
- Molecular physiology of P2X receptors. North, R.A. Physiol. Rev. (2002)
- Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., Di Virgilio, F. J. Exp. Med. (1997)
- The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. Falzoni, S., Munerati, M., Ferrari, D., Spisani, S., Moretti, S., Di Virgilio, F. J. Clin. Invest. (1995)
- ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. Anderson, R.J., Breckon, R., Dixon, B.S. J. Clin. Invest. (1991)
- A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Wiley, J.S., Dao-Ung, L.P., Gu, B.J., Sluyter, R., Shemon, A.N., Li, C., Taper, J., Gallo, J., Manoharan, A. Lancet (2002)
- P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat. Melani, A., Amadio, S., Gianfriddo, M., Vannucchi, M.G., Volontè, C., Bernardi, G., Pedata, F., Sancesario, G. J. Cereb. Blood Flow Metab. (2006)
- Antiapoptotic effects of estrogen in normal and cancer human cervical epithelial cells. Wang, Q., Li, X., Wang, L., Feng, Y.H., Zeng, R., Gorodeski, G. Endocrinology (2004)
- Trehalose uptake through P2X7 purinergic channels provides dehydration protection. Elliott, G.D., Liu, X.H., Cusick, J.L., Menze, M., Vincent, J., Witt, T., Hand, S., Toner, M. Cryobiology (2006)
- Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis. Greig, A.V., Linge, C., Cambrey, A., Burnstock, G. J. Invest. Dermatol. (2003)
- Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors. Sluyter, R., Wiley, J.S. Int. Immunol. (2002)
- Gene structure and chromosomal localization of the human P2X7 receptor. Buell, G.N., Talabot, F., Gos, A., Lorenz, J., Lai, E., Morris, M.A., Antonarakis, S.E. Recept. Channels (1998)
- Proteomic and functional evidence for a P2X7 receptor signalling complex. Kim, M., Jiang, L.H., Wilson, H.L., North, R.A., Surprenant, A. EMBO J. (2001)
- Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. Ferrari, D., Chiozzi, P., Falzoni, S., Dal Susino, M., Melchiorri, L., Baricordi, O.R., Di Virgilio, F. J. Immunol. (1997)
- P2X purinergic receptor channel expression and function in bovine aortic endothelium. Ramirez, A.N., Kunze, D.L. Am. J. Physiol. Heart Circ. Physiol. (2002)
- Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. Greig, A.V., Linge, C., Terenghi, G., McGrouther, D.A., Burnstock, G. J. Invest. Dermatol. (2003)
- Purinergic receptor regulation of LPS-induced signaling and pathophysiology. Guerra, A.N., Fisette, P.L., Pfeiffer, Z.A., Quinchia-Rios, B.H., Prabhu, U., Aga, M., Denlinger, L.C., Guadarrama, A.G., Abozeid, S., Sommer, J.A., Proctor, R.A., Bertics, P.J. J. Endotoxin Res. (2003)
- P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Witting, A., Walter, L., Wacker, J., Möller, T., Stella, N. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes. Sluyter, R., Shemon, A.N., Wiley, J.S. J. Immunol. (2004)
- CD39 modulates endothelial cell activation and apoptosis. Goepfert, C., Imai, M., Brouard, S., Csizmadia, E., Kaczmarek, E., Robson, S.C. Mol. Med. (2000)
- Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression. Potucek, Y.D., Crain, J.M., Watters, J.J. Neurochem. Int. (2006)
- P2X7 receptor activation-induced contraction and lysis in human saphenous vein smooth muscle. Cario-Toumaniantz, C., Loirand, G., Ladoux, A., Pacaud, P. Circ. Res. (1998)
- Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. Torres, G.E., Egan, T.M., Voigt, M.M. J. Biol. Chem. (1999)
- A quantitative analysis of purinoceptor expression in human fetal and adult bladders. O'Reilly, B.A., Kosaka, A.H., Chang, T.K., Ford, A.P., Popert, R., Rymer, J.M., McMahon, S.B. J. Urol. (2001)
- Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines. Lee, D.H., Park, K.S., Kong, I.D., Kim, J.W., Han, B.G. BMC Immunol. (2006)
- Functional and molecular diversity of purinergic ion channel receptors. MacKenzie, A.B., Surprenant, A., North, R.A. Ann. N. Y. Acad. Sci. (1999)
- Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Gu, B.J., Wiley, J.S. Blood (2006)
- MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript. Zhou, L., Qi, X., Potashkin, J.A., Abdul-Karim, F.W., Gorodeski, G.I. J. Biol. Chem. (2008)
- P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Coutinho-Silva, R., Stahl, L., Cheung, K.K., de Campos, N.E., de Oliveira Souza, C., Ojcius, D.M., Burnstock, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)