The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

P2RX4  -  purinergic receptor P2X, ligand gated ion...

Homo sapiens

Synonyms: ATP receptor, P2X purinoceptor 4, P2X4, P2X4R, Purinergic receptor
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of P2RX4


High impact information on P2RX4

  • Homomeric P2X4 receptors are much less sensitive to antagonism by suramin and pyridoxal 5-phosphate-6-azo-2',4'-disulfonic acid [3].
  • Brief (< 1 s) applications of ATP to nodose ganglion neurons or to cells transfected with P2X2 or P2X4 receptor cDNAs induce the opening of a channel selectively permeable to small cations within milliseconds [4].
  • ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells [5].
  • Calcium wave propagation also was reduced by purinergic receptor antagonists and by Cl- channel blockers but insensitive to gap junction inhibitors [6].
  • The assembly of P2X4 with P2X6 subunits results from subunit-dependent interactions, as shown by their specific copurification from HEK-293 cells transiently transfected with various epitope-tagged P2X channel subunits [7].

Biological context of P2RX4


Anatomical context of P2RX4


Associations of P2RX4 with chemical compounds


Other interactions of P2RX4

  • In fetal bladders the expression of P2X1 transcripts was much lower than in adult bladders, and P2X4 and P2X7 were also present [16].
  • The P2X1 receptor was highly specific for human SMC, while the P2X4 was the highest expressed receptor in EC [17].
  • A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy [9].
  • Absence of the responses of alphabeta-methylene ATP and 2-methylthio-ATP excluded functionally active P2X3, P2X4, and P2Y1 receptors as far as [Ca2+]i increase is concerned [18].
  • Single-point Monks-Kaplan analysis provided evidence of association between central fat mass and SNPs in two genes - PLA2G1B (P = 0.0067) and P2RX4 (P = 0.017) [19].

Analytical, diagnostic and therapeutic context of P2RX4

  • We identified the P2X subtypes present in BAECs using RT-PCR. mRNA was present for only three of seven family members: P2X4, P2X5, and P2X7 [11].
  • We confirmed, by immunocytochemistry, the presence of P2X4 and P2X7 protein [11].
  • Moreover, we have demonstrated that the increase in the P2X4 expression is yet another feature of an inflammatory response identified in DNA arrays of dystrophic muscle [13].
  • Electrophoretic mobility shift assays showed a marked decrease in binding of Sp1 to the Sp1 consensus element in shear-stressed cells, suggesting that Sp1 mediates the shear stress-induced downregulation of P2X4 gene transcription [10].
  • Radiation hybrid mapping indicated that this is within 130 kb of the gene for the homologous P2X4 receptor [20].


  1. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. Locovei, S., Scemes, E., Qiu, F., Spray, D.C., Dahl, G. FEBS Lett. (2007) [Pubmed]
  2. Purinoceptors in microglia and neuropathic pain. Trang, T., Beggs, S., Salter, M.W. Pflugers Arch. (2006) [Pubmed]
  3. Pharmacology of cloned P2X receptors. North, R.A., Surprenant, A. Annu. Rev. Pharmacol. Toxicol. (2000) [Pubmed]
  4. Pore dilation of neuronal P2X receptor channels. Virginio, C., MacKenzie, A., Rassendren, F.A., North, R.A., Surprenant, A. Nat. Neurosci. (1999) [Pubmed]
  5. ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. Anderson, R.J., Breckon, R., Dixon, B.S. J. Clin. Invest. (1991) [Pubmed]
  6. Connexins regulate calcium signaling by controlling ATP release. Cotrina, M.L., Lin, J.H., Alves-Rodrigues, A., Liu, S., Li, J., Azmi-Ghadimi, H., Kang, J., Naus, C.C., Nedergaard, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor. Lê, K.T., Babinski, K., Séguéla, P. J. Neurosci. (1998) [Pubmed]
  8. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Garcia-Guzman, M., Soto, F., Gomez-Hernandez, J.M., Lund, P.E., Stühmer, W. Mol. Pharmacol. (1997) [Pubmed]
  9. A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy. Yang, A., Sonin, D., Jones, L., Barry, W.H., Liang, B.T. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  10. Sp1-mediated downregulation of P2X4 receptor gene transcription in endothelial cells exposed to shear stress. Korenaga, R., Yamamoto, K., Ohura, N., Sokabe, T., Kamiya, A., Ando, J. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  11. P2X purinergic receptor channel expression and function in bovine aortic endothelium. Ramirez, A.N., Kunze, D.L. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  12. P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. Glass, R., Loesch, A., Bodin, P., Burnstock, G. Cell. Mol. Life Sci. (2002) [Pubmed]
  13. Enhanced expression of the P2X4 receptor in Duchenne muscular dystrophy correlates with macrophage invasion. Yeung, D., Kharidia, R., Brown, S.C., Górecki, D.C. Neurobiol. Dis. (2004) [Pubmed]
  14. A C-terminal lysine that controls human P2X4 receptor desensitization. Fountain, S.J., North, R.A. J. Biol. Chem. (2006) [Pubmed]
  15. Cibacron blue allosterically modulates the rat P2X4 receptor. Miller, K.J., Michel, A.D., Chessell, I.P., Humphrey, P.P. Neuropharmacology (1998) [Pubmed]
  16. A quantitative analysis of purinoceptor expression in human fetal and adult bladders. O'Reilly, B.A., Kosaka, A.H., Chang, T.K., Ford, A.P., Popert, R., Rymer, J.M., McMahon, S.B. J. Urol. (2001) [Pubmed]
  17. P2 receptor expression profiles in human vascular smooth muscle and endothelial cells. Wang, L., Karlsson, L., Moses, S., Hultgårdh-Nilsson, A., Andersson, M., Borna, C., Gudbjartsson, T., Jern, S., Erlinge, D. J. Cardiovasc. Pharmacol. (2002) [Pubmed]
  18. Membrane-specific expression of functional purinergic receptors in normal human nasal epithelial cells. Kim, C.H., Kim, S.S., Choi, J.Y., Shin, J.H., Kim, J.Y., Namkung, W., Lee, J.G., Lee, M.G., Yoon, J.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  19. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort. Wilson, S.G., Adam, G., Langdown, M., Reneland, R., Braun, A., Andrew, T., Surdulescu, G.L., Norberg, M., Dudbridge, F., Reed, P.W., Sambrook, P.N., Kleyn, P.W., Spector, T.D. Eur. J. Hum. Genet. (2006) [Pubmed]
  20. Gene structure and chromosomal localization of the human P2X7 receptor. Buell, G.N., Talabot, F., Gos, A., Lorenz, J., Lai, E., Morris, M.A., Antonarakis, S.E. Recept. Channels (1998) [Pubmed]
WikiGenes - Universities