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Gene Review

ECs3550  -  glutamate--cysteine ligase

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of ECs3550

 

High impact information on ECs3550

 

Chemical compound and disease context of ECs3550

 

Biological context of ECs3550

 

Anatomical context of ECs3550

 

Associations of ECs3550 with chemical compounds

 

Analytical, diagnostic and therapeutic context of ECs3550

References

  1. Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. Huang, C.S., Chang, L.S., Anderson, M.E., Meister, A. J. Biol. Chem. (1993) [Pubmed]
  2. The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase. Powles, R., Deane, S., Rawlings, D. Microbiology (Reading, Engl.) (1996) [Pubmed]
  3. Cloning, biochemical and phylogenetic characterizations of gamma-glutamylcysteine synthetase from Anabaena sp. PCC 7120. Ashida, H., Sawa, Y., Shibata, H. Plant Cell Physiol. (2005) [Pubmed]
  4. Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis. Hibi, T., Nii, H., Nakatsu, T., Kimura, A., Kato, H., Hiratake, J., Oda, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: a possible model for mammalian cell protection. Moore, W.R., Anderson, M.E., Meister, A., Murata, K., Kimura, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. The nucleotide sequence of the gene for gamma-glutamylcysteine synthetase of Escherichia coli. Watanabe, K., Yamano, Y., Murata, K., Kimura, A. Nucleic Acids Res. (1986) [Pubmed]
  7. Cadmium tolerance and accumulation in Indian mustard is enhanced by overexpressing gamma-glutamylcysteine synthetase. Zhu, Y.L., Pilon-Smits, E.A., Tarun, A.S., Weber, S.U., Jouanin, L., Terry, N. Plant Physiol. (1999) [Pubmed]
  8. ATP-dependent inactivation of Escherichia coli gamma-glutamylcysteine synthetase by L-glutamic acid gamma-monohydroxamate. Katoh, M., Hiratake, J., Oda, J. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
  9. Recognition of a cysteine substrate by E. coli gamma-glutamylcysteine synthetase probed by sulfoximine-based transition-state analogue inhibitors. Hiratake, J., Irie, T., Tokutake, N., Oda, J. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  10. Construction of glutathione-producing strains of Escherichia coli B by recombinant DNA techniques. Gushima, H., Miya, T., Murata, K., Kimura, A. J. Appl. Biochem. (1983) [Pubmed]
  11. Modification of thiol contents in poplars (Populus tremula x P. alba) overexpressing enzymes involved in glutathione synthesis. Arisi, A.C., Noctor, G., Foyer, C.H., Jouanin, L. Planta (1997) [Pubmed]
  12. The oxygen effect: variation of the K-value and lifetimes of O2-dependent damage in some glutathione-deficient mutants of Escherichia coli. Harrop, H.A., Held, K.D., Michael, B.D. Int. J. Radiat. Biol. (1991) [Pubmed]
  13. Redox regulation of pro-inflammatory cytokines and IkappaB-alpha/NF-kappaB nuclear translocation and activation. Haddad, J.J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  14. Escherichia coli B gamma-glutamylcysteine synthetase: modification, purification, crystallization and preliminary crystallographic analysis. Hibi, T., Hisada, H., Nakatsu, T., Kato, H., Oda, J. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
 
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