Gene Review:
ECs1029 - dihydroorotate dehydrogenase 2
Escherichia coli O157:H7 str. Sakai
- The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers. Nielsen, F.S., Andersen, P.S., Jensen, K.F. J. Biol. Chem. (1996)
- A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism. Marcinkeviciene, J., Jiang, W., Locke, G., Kopcho, L.M., Rogers, M.J., Copeland, R.A. Arch. Biochem. Biophys. (2000)
- Crystallization and preliminary X-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenase. Rowland, P., Nørager, S., Jensen, K.F., Larsen, S. Acta Crystallogr. D Biol. Crystallogr. (2000)
- Cloning, nucleotide sequence and regulation of the Salmonella typhimurium pyrD gene encoding dihydroorotate dehydrogenase. Frick, M.M., Neuhard, J., Kelln, R.A. Eur. J. Biochem. (1990)
- Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium. Chen, S.F., Perrella, F.W., Behrens, D.L., Papp, L.M. Cancer Res. (1992)
- Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. Baldwin, J., Farajallah, A.M., Malmquist, N.A., Rathod, P.K., Phillips, M.A. J. Biol. Chem. (2002)
- Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. Shi, J., Palfey, B.A., Dertouzos, J., Jensen, K.F., Gafni, A., Steel, D. J. Am. Chem. Soc. (2004)
- Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies. Palfey, B.A., Björnberg, O., Jensen, K.F. Biochemistry (2001)
- Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms. Sariego, I., Annoura, T., Nara, T., Hashimoto, M., Tsubouchi, A., Iizumi, K., Makiuchi, T., Murata, E., Kita, K., Aoki, T. Parasitol. Int. (2006)
- The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis. Rowland, P., Nielsen, F.S., Jensen, K.F., Larsen, S. Structure (1997)
- Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase. Feliciano, P.R., Cordeiro, A.T., Costa-Filho, A.J., Nonato, M.C. Protein Expr. Purif. (2006)
- Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones. Marcinkeviciene, J., Rogers, M.J., Kopcho, L., Jiang, W., Wang, K., Murphy, D.J., Lippy, J., Link, S., Chung, T.D., Hobbs, F., Haque, T., Trainor, G.L., Slee, A., Stern, A.M., Copeland, R.A. Biochem. Pharmacol. (2000)
- Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Löffler, M., Larsen, S. Protein Sci. (2004)
- Sequence analysis of a Dictyostelium discoideum gene coding for an active dihydroorotate dehydrogenase in yeast. Jacquet, M., Kalekine, M., Boy-Marcotte, E. Biochimie (1985)