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Gene Review

ZW10  -  zw10 kinetochore protein

Homo sapiens

Synonyms: Centromere/kinetochore protein zw10 homolog, HZW10, KNTC1AP
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Disease relevance of ZW10

  • These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progression of tobacco smoke-induced adenocarcinoma of the lung [1].

High impact information on ZW10


Associations of ZW10 with chemical compounds

  • We therefore conclude that Aurora B kinase activity is required for the accumulation of tension-sensitive mitotic-checkpoint components, such as hZW10 and hROD, in order to maintain mitotic-checkpoint arrest [3].

Biological context of ZW10

  • ZW10, a dynamitin-interacting protein associated with kinetochores, is known to participate directly in turning off of the spindle checkpoint [4].
  • The present results disclose an unexpected role for a spindle checkpoint protein, ZW10, during interphase [4].
  • As ZW10 and Zwint-1 are absent from yeast, we reasoned that metazoans evolved an elaborate spindle checkpoint machinery to ensure faithful chromosome segregation in mitosis [5].
  • However, the excess CENP-C does not disrupt the native centromeres detectably and does not associate with another conserved centromere protein, ZW10 [6].
  • Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor [7].

Anatomical context of ZW10


Physical interactions of ZW10


Regulatory relationships of ZW10


Other interactions of ZW10


Analytical, diagnostic and therapeutic context of ZW10

  • Overexpression, microinjection and knockdown experiments revealed that ZW10 is involved in membrane trafficking between the endoplasmic reticulum and Golgi [4].
  • This study presents the results of tests that were carried out at the Institutes for Desert Research, Kiryat Sde-Boker, Israel, and focused on the influence of hydrodynamic conditions on fouling in a pilot-scale immersed membrane bioreactor (IMBR) using a hollow fiber membrane module of ZW-10 (Zenon Environmental, Canada) under ambient conditions [14].


  1. Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Miura, K., Bowman, E.D., Simon, R., Peng, A.C., Robles, A.I., Jones, R.T., Katagiri, T., He, P., Mizukami, H., Charboneau, L., Kikuchi, T., Liotta, L.A., Nakamura, Y., Harris, C.C. Cancer Res. (2002) [Pubmed]
  2. Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function. Varma, D., Dujardin, D.L., Stehman, S.A., Vallee, R.B. J. Cell Biol. (2006) [Pubmed]
  3. Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Famulski, J.K., Chan, G.K. Curr. Biol. (2007) [Pubmed]
  4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. Hirose, H., Arasaki, K., Dohmae, N., Takio, K., Hatsuzawa, K., Nagahama, M., Tani, K., Yamamoto, A., Tohyama, M., Tagaya, M. EMBO J. (2004) [Pubmed]
  5. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. Wang, H., Hu, X., Ding, X., Dou, Z., Yang, Z., Shaw, A.W., Teng, M., Cleveland, D.W., Goldberg, M.L., Niu, L., Yao, X. J. Biol. Chem. (2004) [Pubmed]
  6. CENP-C is necessary but not sufficient to induce formation of a functional centromere. Fukagawa, T., Pendon, C., Morris, J., Brown, W. EMBO J. (1999) [Pubmed]
  7. ZW10 links mitotic checkpoint signaling to the structural kinetochore. Kops, G.J., Kim, Y., Weaver, B.A., Mao, Y., McLeod, I., Yates, J.R., Tagaya, M., Cleveland, D.W. J. Cell Biol. (2005) [Pubmed]
  8. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Williams, B.C., Li, Z., Liu, S., Williams, E.V., Leung, G., Yen, T.J., Goldberg, M.L. Mol. Biol. Cell (2003) [Pubmed]
  9. RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. Arasaki, K., Taniguchi, M., Tani, K., Tagaya, M. Mol. Biol. Cell (2006) [Pubmed]
  10. HZwint-1, a novel human kinetochore component that interacts with HZW10. Starr, D.A., Saffery, R., Li, Z., Simpson, A.E., Choo, K.H., Yen, T.J., Goldberg, M.L. J. Cell. Sci. (2000) [Pubmed]
  11. Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. Sun, Y., Shestakova, A., Hunt, L., Sehgal, S., Lupashin, V., Storrie, B. Mol. Biol. Cell (2007) [Pubmed]
  12. Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. Van Hooser, A.A., Ouspenski, I.I., Gregson, H.C., Starr, D.A., Yen, T.J., Goldberg, M.L., Yokomori, K., Earnshaw, W.C., Sullivan, K.F., Brinkley, B.R. J. Cell. Sci. (2001) [Pubmed]
  13. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. Musio, A., Mariani, T., Montagna, C., Zambroni, D., Ascoli, C., Ried, T., Vezzoni, P. Gene (2004) [Pubmed]
  14. Optimal performance of an immersed membrane bioreactor equipped with a draft tube for domestic wastewater reclamation. Yang, F., Bick, A., Shandalov, S., Oron, G. Water Sci. Technol. (2006) [Pubmed]
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