Gene Review:
SOCS6 - suppressor of cytokine signaling 6
Homo sapiens
Synonyms:
CIS-4, CIS4, Cish4, Cytokine-inducible SH2 protein 4, HSPC060, ...
- Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer. Storojeva, I., Boulay, J.L., Ballabeni, P., Buess, M., Terracciano, L., Laffer, U., Mild, G., Herrmann, R., Rochlitz, C. Oncology (2005)
- The role of signal transducers and activators of transcription in T inflammatory bowel diseases. Mudter, J., Neurath, M.F. Inflamm. Bowel Dis. (2003)
- STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Di Stefano, A., Caramori, G., Capelli, A., Gnemmi, I., Ricciardolo, F.L., Oates, T., Donner, C.F., Chung, K.F., Barnes, P.J., Adcock, I.M. Eur. Respir. J. (2004)
- The classification of multiple somatoform symptoms. Rief, W., Heuser, J., Mayrhuber, E., Stelzer, I., Hiller, W., Fichter, M.M. J. Nerv. Ment. Dis. (1996)
- Promoting reflection on professionalism: a comparison trial of educational interventions for medical students. Baernstein, A., Fryer-Edwards, K. Academic medicine : journal of the Association of American Medical Colleges. (2003)
- Structure of the amino-terminal protein interaction domain of STAT-4. Vinkemeier, U., Moarefi, I., Darnell, J.E., Kuriyan, J. Science (1998)
- Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. Nolte, D., Niemann, S., Müller, U. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. Torpey, N., Maher, S.E., Bothwell, A.L., Pober, J.S. J. Biol. Chem. (2004)
- Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation. Hwang, M.N., Ha, T.H., Park, J., Shim, J., Lee, H., Kim, Y.N., Lee, E.S., Yoon, S. Biochem. Biophys. Res. Commun. (2007)
- STAT4 requires the N-terminal domain for efficient phosphorylation. Chang, H.C., Zhang, S., Oldham, I., Naeger, L., Hoey, T., Kaplan, M.H. J. Biol. Chem. (2003)
- Regulation of c-myc transcription by interleukin-2 (IL-2). Identification of a novel IL-2 response element interacting with STAT-4. Grigorieva, I., Grigoriev, V.G., Rowney, M.K., Hoover, R.G. J. Biol. Chem. (2000)
- Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4. Moriggl, R., Kristofic, C., Kinzel, B., Volarevic, S., Groner, B., Brinkmann, V. J. Immunol. (1998)
- Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview. Di Stefano, A., Caramori, G., Ricciardolo, F.L., Capelli, A., Adcock, I.M., Donner, C.F. Clin. Exp. Allergy (2004)
- Accumulation of transcripts in the mature human sperm nucleus: implication of the haploid genome in a functional role. Siffroi, J.P., Dadoune, J.P. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia. (2001)
- IFN-gamma is only partially restored by co-stimulation with IL-12, IL-2, IL-15, IL-18 or engagement of CD28. Jung, T., Witzak, K., Dieckhoff, K., Zachmann, K., Heidrich, S., Aversa, G., Neumann, C. Clin. Exp. Allergy (1999)