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Gene Review

ARHGEF11  -  Rho guanine nucleotide exchange factor...

Homo sapiens

Synonyms: GTRAP48, KIAA0380, PDZ-RHOGEF, PDZ-RhoGEF, Rho guanine nucleotide exchange factor 11
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Disease relevance of ARHGEF11


High impact information on ARHGEF11

  • Here we report the identification and characterization of two proteins, GTRAP41 and GTRAP48 (for glutamate transporter EAAT4 associated protein) that specifically interact with the intracellular carboxy-terminal domain of EAAT4 and modulate its glutamate transport activity [3].
  • In addition, a dominant-negative form of PDZ-RhoGEF blocks semaphorin 4D-induced growth cone collapse in primary hippocampal neurons [4].
  • This interaction results in the phosphorylation of PDZ RhoGEF and abolishes its ability to mediate the accumulation of Rho-GTP by Galpha13 [5].
  • Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton [6].
  • Extensive deletion mutagenesis revealed the presence of a novel 25-amino acid sequence in PDZ-RhoGEF, located at amino acids 561-585, that is necessary and sufficient for localization to the actin cytoskeleton and interaction with actin [6].

Anatomical context of ARHGEF11


Associations of ARHGEF11 with chemical compounds


Other interactions of ARHGEF11

  • These include the direct association of their RGS domain with GTP-bound forms of Galpha(12/13) and the binding of the PDZ domain present in PDZ-RhoGEF and LARG to plexins, which are receptors for semaphorins [10].
  • In contrast, GTRAP48, a homolog of p115 RhoGEF, bound to Galpha(13) but was not stimulated by the alpha subunit and had very poor GAP activity [11].
  • Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF [12].
  • This report demonstrates that PDZ-RhoGEF, a member of a subfamily of RhoGEFs that contain regulator of G protein signaling domains, is partially localized at or near the plasma membranes in 293T, COS-7, and Neuro2a cells, and this localization is coincident with cortical actin [6].
  • The results suggest that there are interactions between RGS2, RGS6, and PDZ-RhoGEF and validate this family of proteins as key regulators of tumorigenesis [2].

Analytical, diagnostic and therapeutic context of ARHGEF11


  1. Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. Togashi, H., Nagata, K., Takagishi, M., Saitoh, N., Inagaki, M. J. Biol. Chem. (2000) [Pubmed]
  2. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Gu, J., Wu, X., Dong, Q., Romeo, M.J., Lin, X., Gutkind, J.S., Berman, D.M. Cancer (2006) [Pubmed]
  3. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Jackson, M., Song, W., Liu, M.Y., Jin, L., Dykes-Hoberg, M., Lin, C.I., Bowers, W.J., Federoff, H.J., Sternweis, P.C., Rothstein, J.D. Nature (2001) [Pubmed]
  4. Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Swiercz, J.M., Kuner, R., Behrens, J., Offermanns, S. Neuron (2002) [Pubmed]
  5. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. Barac, A., Basile, J., Vázquez-Prado, J., Gao, Y., Zheng, Y., Gutkind, J.S. J. Biol. Chem. (2004) [Pubmed]
  6. Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Banerjee, J., Wedegaertner, P.B. Mol. Biol. Cell (2004) [Pubmed]
  7. Expression of ARHGEF11 mRNA in schizophrenic thalamus. Davidkova, G., McCullumsmith, R.E., Meador-Woodruff, J.H. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  8. Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. Rümenapp, U., Blomquist, A., Schwörer, G., Schablowski, H., Psoma, A., Jakobs, K.H. FEBS Lett. (1999) [Pubmed]
  9. Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Ohtsu, H., Mifune, M., Frank, G.D., Saito, S., Inagami, T., Kim-Mitsuyama, S., Takuwa, Y., Sasaki, T., Rothstein, J.D., Suzuki, H., Nakashima, H., Woolfolk, E.A., Motley, E.D., Eguchi, S. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  10. Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. Vázquez-Prado, J., Basile, J., Gutkind, J.S. Meth. Enzymol. (2004) [Pubmed]
  11. Mechanisms for reversible regulation between G13 and Rho exchange factors. Wells, C.D., Liu, M.Y., Jackson, M., Gutowski, S., Sternweis, P.M., Rothstein, J.D., Kozasa, T., Sternweis, P.C. J. Biol. Chem. (2002) [Pubmed]
  12. Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF. Oleksy, A., Barton, H., Devedjiev, Y., Purdy, M., Derewenda, U., Otlewski, J., Derewenda, Z.S. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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