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Gene Review

PSMD6  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit RPN7, 26S proteasome regulatory subunit S10, Breast cancer-associated protein SGA-113M, KIAA0107, ...
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Disease relevance of PSMD6

  • The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma [1].
  • It is time to focus on preventive strategies directed at curtailing these 'learned behaviours', that we have acquired during the transition from the stone-age to the chip-age, if we want to hold the current pandemic of obesity.International Journal of Obesity (2006) 30, S4-S10. doi:10.1038/sj.ijo.0803513 [2].
  • We studied a panel of newly developed chalcone analogues (S1-S10) using MDA-MB 231 and MCF-7 ADRr breast cancer cells and the T-leukemic Jurkat cell line [3].
  • The Rice black-streaked dwarf virus (RBSDV) virion is composed of two layers of capsid proteins and 10 segments of double-stranded genomic RNA (S1-S10) [4].

High impact information on PSMD6

  • The consensus binding site for the RNA.MDM2 complex within p53 is SGXLLGESXF, which links the S9-S10 beta-sheets flanking the BOX-IV and BOX-V motifs in the core domain and which is a site of reversible conformational flexibility in p53 [5].
  • (J Cardiovasc Electrophysiol, Vol. 17, pp. S7-S10, Suppl. 2, September 2006) [6].
  • Cortisol demonstrated significant increases in response to the S10/3 protocol at 0 min, to the H10/1 protocol at midexercise and at 0 and 5 min postexercise, and to the H5/1 protocol at 5 and 15 min postexercise [7].
  • The most common abnormality detected with comparative genomic hybridization (CGH) was deletions of chromosome 3p, with loss of the RASSF1, FHIT, and p44S10 loci frequently involved [8].
  • Before training (S0) and at the 10th, 20th, 30th, 40th weeks (S10, S20, S30, S40) of the training program, ventilatory AT (AT vent), lactate AT (AT lact), and 4 mmol AT were estimated using a graded exercise test [9].

Biological context of PSMD6

  • This surprising result suggested S10 phosphorylation might be required for targeting the second site [10].
  • Finally, we found that in cultured cells under physiologically relevant conditions such as oxidative stress or growth factor deprivation, endogenous Akt1 causes p27 accumulation by phosphorylating S10 [10].

Associations of PSMD6 with chemical compounds

  • We tested this idea by replacing S10 with threonine, which as expected led to the appearance of phospho-threonine [10].
  • P27 phosphorylated by Akt1 was detected by a phospho-S10 specific antibody, confirming this serine was targeted [10].

Analytical, diagnostic and therapeutic context of PSMD6

  • The circular dichroism spectra in these two media have the same shape, indicative of a similar preferred conformation [Mammi, S., Mammi, N. J., Foffani, M. T., Peggion, E., Moroder, L., & Wünsch, E. (1987) Biopolymers 26, S1-S10] [11].
  • S10 cellular repair of striatal motor and cognitive functions in animal models of huntington disease [12].


  1. The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. Ren, S., Smith, M.J., Louro, I.D., McKie-Bell, P., Bani, M.R., Wagner, M., Zochodne, B., Redden, D.T., Grizzle, W.E., Wang, N., Smith, D.I., Herbst, R.A., Bardenheuer, W., Opalka, B., Schütte, J., Trent, J.M., Ben-David, Y., Ruppert, J.M. Oncogene (2000) [Pubmed]
  2. Obesity during growth in Switzerland: role of early socio-cultural factors favouring sedentary activities. Suter, P.M., Ruckstuhl, N. International journal of obesity (2005) (2006) [Pubmed]
  3. In vitro evaluation of newly developed chalcone analogues in human cancer cells. De Vincenzo, R., Ferlini, C., Distefano, M., Gaggini, C., Riva, A., Bombardelli, E., Morazzoni, P., Valenti, P., Belluti, F., Ranelletti, F.O., Mancuso, S., Scambia, G. Cancer Chemother. Pharmacol. (2000) [Pubmed]
  4. Development of an ID-ELISA for the detection of Riceblack-streakeddwarfvirus in plants. Wang, Z.H., Fang, S.G., Zhang, Z.Y., Han, C.G., Li, D.W., Yu, J.L. J. Virol. Methods (2006) [Pubmed]
  5. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. Shimizu, H., Burch, L.R., Smith, A.J., Dornan, D., Wallace, M., Ball, K.L., Hupp, T.R. J. Biol. Chem. (2002) [Pubmed]
  6. Assessment of rhythm and rate control in patients with atrial fibrillation. Prystowsky, E.N. J. Cardiovasc. Electrophysiol. (2006) [Pubmed]
  7. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. Kraemer, W.J., Fleck, S.J., Dziados, J.E., Harman, E.A., Marchitelli, L.J., Gordon, S.E., Mello, R., Frykman, P.N., Koziris, L.P., Triplett, N.T. J. Appl. Physiol. (1993) [Pubmed]
  8. A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma. Strefford, J.C., Stasevich, I., Lane, T.M., Lu, Y.J., Oliver, T., Young, B.D. Cancer Genet. Cytogenet. (2005) [Pubmed]
  9. Effect of 40 weeks of endurance training on the anaerobic threshold. Denis, C., Fouquet, R., Poty, P., Geyssant, A., Lacour, J.R. International journal of sports medicine. (1982) [Pubmed]
  10. Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region. Nacusi, L.P., Sheaff, R.J. Cell division [electronic resource]. (2006) [Pubmed]
  11. Conformational studies of human [15-2-aminohexanoic acid]little gastrin in sodium dodecyl sulfate micelles by 1H NMR. Mammi, S., Peggion, E. Biochemistry (1990) [Pubmed]
  12. S10 cellular repair of striatal motor and cognitive functions in animal models of huntington disease. Dunnett, S.B. Behavioural pharmacology. (2006) [Pubmed]
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