Disease relevance of Lercanidipine

• Large-scale clinical trials have established that lowering blood pressure in patients with mild to moderate diastolic hypertension results in a decreased incidence of stroke and, to a lesser extent, a reduction in incidence of coronary heart disease [MacMahon SW, Cutler JA, Furberg CD, et al: Prog Cardiovasc Dis 1986; 29 (suppl 1): 99-118] [1].
• Re: 'Ventricular arrhythmias induced by endothelin-1 or by acute ischemia: a comparative analysis using three dimensional mapping' (Cardiovasc Res 2000;45:310-320) [2].
• [Cardiovasc. Res. 59 (2003) 538-548], Epo can also act within the cardiovascular system with effects in thrombosis and hypertension as well as actions on platelets, vascular endothelium and smooth muscle, and myocytes of the heart [3].
• To maximize the information one can obtain from the temporal curves of creatine kinase (CK) after acute myocardial infarct (AMI), the authors tested how well the curves were fit by three functions: the log-normal function, the gamma function, and the function of Schwerdt and associates (Cardiovasc Res 1990;24:328-334) [4].
• Reply to invited letter concerning: neonatal aortic stenosis. The balloon deflated? (J Thorac Cardiovasc Surg 1990;100:927-89) [5].

Psychiatry related information on Lercanidipine

• Considerable evidence documents that young children evidence significant psychopathology (cf., Del Carmen & Carter, in press; Emde, 1999; Zeanah, 2001; Zeanah et al., 1997) [6].

High impact information on Lercanidipine

• The cardiotonic effects of thiadiazinone derivative EMD 57033 are mediated by direct actions on myofilaments (Lues, I., Beier, N., Jonas, R., Klockow, M., and Haeusler, G. J. (1993) Cardiovasc. Pharmacol. 21, 883-892) [7].
• Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin content. [Cardiovasc. Res. 2002;55:369-374] [8].
• Blood pressure and insulin resistance: role for microvascular function?. [Cardiovasc Res 2002;53:271-276] [9].
• Jose and Collison published a study on the normal range and the determinants of intrinsic heart rate in man in Cardiovascular Research in 1970 [Jose AD, Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res 1970; 4: 160-167)] [10].
• OBJECTIVES: The stoichiometric binding model (Frelin C, Guedin D. Cardiovasc Res 1994;28:1613-1622) implies that most endothelin in tissues is bound onto receptors rather than in a free state [11].

Chemical compound and disease context of Lercanidipine

• Reply to: Amiodarone and quinidine for postoperative atrial arrhythmias (J Thorac Cardiovasc Surg 1990;99:942) [12].

Biological context of Lercanidipine

• Inhibition of blood coagulation has been proposed to have several potential therapeutic utilities (Kaiser and Hauptmann, Cardiovasc. Drug Rev. 1994, 12, 225-236) [13].
• Myelin: development, disorders and neural repair. A satellite meeting of the International and American Societies for Neurochemistry joint meeting in Buenos Aires. Bastion del Carmen, September 1-4, 2001, Colonia, Uruguay [14].
• Invited letter concerning: myocardial temperature management during aortic clamping for cardiac surgery: protection, preoccupation, and perspective (J Thorac Cardiovasc Surg 1991;102:895-903) [15].
• A reduced activity of cardiac vagal afferent fibres is considered as one of the pathophysiological causes of post-infarction complications [A. Head, Baroreflexes and cardiovascular regulation in hypertension. J. Cardiovasc. Pharmacol. 26 (1995) S7-S16] [16].
• UV-irradiated mesophyll protoplasts of C. abyssinica cv 'Carmen' and cv 'Galactica' were fused with hypocotyl protoplasts of different genotypes of B. napus cv 'Maplus' and breeding line '11502'. Shoot regeneration frequency varied between 6.1% and 20.8% among the different doses of UV-irradiation, ranging from 0.05 J/cm(2) to 0.30 J/cm(2) [17].

Anatomical context of Lercanidipine

• Clinical evaluation of the omniscience cardiac valve prosthesis (J Thorac Cardiovasc Surg 1992; 103:259-66) [18].
• Invited letter concerning: balloon dilation of stenotic aortic valve in children--an intraoperative study (J Thorac Cardiovasc Surg 1992; 104:1709-13) [19].
• We have recently demonstrated that a significant cardiac damage including myocytes injury, inflammation, and fibrosis, was found in dystrophin-deficient myocardium during pressure overload [Kamogawa et al., 2001: Cardiovasc Res 50:509-515] [20].
• Reply to invited letter concerning: Endothelial preservation in human saphenous veins (J Thorac Cardiovasc Surg 1990;100:149-50) [21].
• Invited letter concerning: experience with 205 procedures of transcatheter closure of ductus arteriosus in 182 patients, with special reference to residual shunts and long-term follow-up (J Thorac Cardiovasc Surg 1992;104:1721-7) [22].

Associations of Lercanidipine with other chemical compounds

• Barve; (3) The role of mitochondria in ethanol-mediated sensitization of the liver, by Anna Colell, Carmen Garcia-Ruiz, Neil Kaplowitz, and Jose C [23].
• This hemodynamic behavior is also observed in experiments in vitro (Steen and Steen, 1994, Cardiovasc. Res., 28, pp. 1821-1827) and in measurements in vivo with color M-mode Doppler echocardiography (Stugaard et al., 1994, J. Am. Coll. Cardiol., 24, 663-670) [24].
• METHODS: The variation of appearance, pore form and percentage porosity with sintering time and temperature was studied for five dental dentine porcelains, two aluminous: Alpha (Vita Zahnfabrik, Bad Säckingen, Germany) and Vitadur-N (Vita); and three feldspathic: Omega (Vita), VMK68 (Vita) and Carmen (Esprident, Ispringen, Germany) [25].
• The present studies were undertaken to examine the in vitro calcium antagonistic properties of lercanidipine (CAS 132866-11-6, Rec 15/2375) in vascular and non-vascular tissues, as well as its binding profile and in particular its affinity to the calcium channel binding sites [26].

Gene context of Lercanidipine

• Reply to invited letter concerning: Long-term results of the Belsey Mark IV antireflux operation in relation to the severity of esophagitis (J Thorac Cardiovasc Surg 1990;100:624-5) [27].
• Reply to invited letter concerning: Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy (J Thorac Cardiovasc Surg 1991;102:156-7) [28].
• Repair of subdivided left atrium associated with a persistent left superior vena cava (van Son and Hambsch; J Thorac Cardiovasc Surg 1998;116:535) [29].
• (Orringer MB, Skinner DB, Belsey RHR. Long-term results of the Mark IV operation for hiatal hernia and analyses of recurrences and their treatment. J Thorac Cardiovasc Surg 1972;63:25-33) [30].
• RESULTS: HTLV-I antibodies were present in 2.5% (14/568) of women (1.3% in Huanta, 3.8% in El Carmen, and 3.8% in Lima); 2.5%, 2.7% and 2.6% of Quechuans, Mestizas and African-Americans, respectively, were infected [31].

Analytical, diagnostic and therapeutic context of Lercanidipine

• Subsequent European and North American clinical trials in patients with DCM of varying aetiologies have shown equal promise and an absence of device related complications (Circulation 104(12 Suppl. 1) (2001) I270); (Ann. Thorac. Cardiovasc. Surg. 7(5) (2001) 278) [32].
• Reply to: neutrophil activation during cardiopulmonary bypass (J Thorac Cardiovasc Surg 1992;104:1746-8) [33].
• Invited letter concerning: biochemical and cellular characterization of cardiac valve tissue after cryopreservation or antibiotic preservation (J Thorac Cardiovasc Surg 1994;108:63-7) [34].
• Reply to invited letter concerning: Informed consent for blood transfusion (J Thorac Cardiovasc Surg 1991;101:563-4) [35].
• Invited letter concerning: normocalcemic blood or crystalloid cardioplegia provides superior neonatal myocardial protection over low-calcium cardioplegia (J Thorac Cardiovasc Surg 1993;105:201-6) [36].

References